The NARC-Based Approach to the Enantioselective Synthesis of the Zaragozic Acids. Synthesis of a C 5-Alkoxycarbonyl-Substituted 2,8-Dioxabicyclo[3.2.1]octane.
Patrick Perlmutter and Walailak Selajarern
Australian Journal of Chemistry
53(4) 349 - 353
Published: 2000
Abstract
A direct method for the preparation of C 5-alkoxycarbonyl-substituted 2,8-dioxabicyclo[3.2.1]octanes is described. The key process involves a highly stereoselective (NARC) sequence of a nucleophilic addition followed by ring closure.Keywords: Aldol; anti-cholesterol; bicyclic acetal; heterocycle; NARC (nucleophilic addition– ring closure); squalestatin; stereoselective; synthesis; Wacker; zaragozic acid.
https://doi.org/10.1071/CH00045
© CSIRO 2000
