
TY  - JOUR
A1  - T Blair, H 
A1  - McCutcheon, SN 
A1  - Mackenzie, DDS 
A1  - Gluckman, PD 
A1  - Ormsby, JE 
T1  - Variation in Plasma Concentration of Insulin-like Growth Factor-l and its Covariation with Liveweight in Mice
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1987
VL  - 40
IS  - 3
SP  - 287
EP  - 294
KW  - 
UR  - https://doi.org/10.1071/BI9870287 
N2  - Three experiments were undertaken to examine the degree and causes of variation in plasma concentrations of insulin-like growth factor-l (IOF-I) in mice. The relationship between IOF-l concentrations and liveweight was also examined. In all three experiments, a number of non-genetic factors were found to contribute significantly to the variation in IOF-l concentrations, the most important of these being sex and litter size. In one experiment, where pups from 16 litters were cross-fostered to avoid the confounding of maternal and direct genetic effects, a heritability of 0'40 ± 0·27 was estimated for plasma IOF-l concentration at 35 days of age. To examine further the existence of genetic variation in plasma concentrations of IOF-l and the genetic covariation between plasma IOF-l levels and other body traits, a selection experiment with mice has been initiated. Moderate to strong phenotypic correlations between IOF-l concentrations and weight at an early age have been found in all three experiments. 
ER  -

