
TY  - JOUR
A1  - Brown-Woodman, PDC 
A1  - White, IG 
A1  - Ridleye, DD 
T1  - Antifertility Activity and Toxicity of a-Chlorohydrin Aromatic Ketal Analogues in Male Rats
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1986
VL  - 39
IS  - 2
SP  - 187
EP  - 192
KW  - 
UR  - https://doi.org/10.1071/BI9860187 
N2  - The antifertility activity and toxicity of a-chlorohydrin and seven aromatic ketal derivatives were investigated in male rats. At a dose of 5 mg/kg injected intraperitioneally.each day for 14 days, a-chlorohydrin and the methoxy benzaldehyde derivative (compound 2) produced complete infertility. The benzaldehyde derivative (compound 1) was 89% effective and the other five compounds 71-25% effective. All compounds except the least effective antifertility agent, the methylbenzaldehyde derivative (compound 3), reduced the motility of sperm recovered from the epididymis. None of the compounds caused a decrease in body or testes weight but some increased adrenal weight. 
ER  -

