
TY  - JOUR
A1  - A Day, Trevor 
A1  - J West, Malcolm 
A1  - O Willoughby, John 
T1  - Stress Suppression of Growth Hormone Secretion in the Rat: Effects of Disruption of Inhibitory Noradrenergic Afferents to the Median Eminence
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1983
VL  - 36
IS  - 6
SP  - 525
EP  - 530
KW  - 
UR  - https://doi.org/10.1071/BI9830525 
N2  - The participation of a growth hormone (GH) inhibitory noradrenergic input to the median eminence in stress-induced suppression of rat GH secretion was investigated in animals with median eminence catecholamine lesions produced by intravenous injection of6-hydroxydopamine (6-0HDA). Unstressed lesioned rats exhibited an enhanced frequency of GH secretory bursts, but both intact and lesioned rats responded to stress with suppression of GH (controls: 56% suppression, 6-0HDA lesioned: 43% suppression, not significantly different). Thus noradrenergic projections to the median eminence, if they participate at all in stress-induced GH suppression, appear to have only a minor role. This study does not exclude the possibility that circulating adrenaline of adrenal medullary origin might obscure defects in GH control produced by noradrenergic denervation of the median eminence. 
ER  -

