
%0 Journal Article
%A Reanney, DC 
%A MacPhee, DG 
%A Pressing, J 
%T Intrinsic Noise and the Design of the Genetic Machinery
%J Australian Journal of Biological Sciences
%D 1983/02/01
%V 36
%N 1
%P 77-90
%K 
%R https://doi.org/10.1071/BI9830077
%U https://www.publish.csiro.au/paper/BI9830077 
%X Darwinian theory envisages 'selection pressure' as a stress imposed on the genotype by the environment. However, noise in the replicative and translational mechanisms in itself imposes a significant 'pressure' on the adaptive fitness of the organism. We propose that the biosphere has been shaped by both extrinsic (environmental) and intrinsic (noise-generated) factors. Because noise has been a remorseless and ever-present background to the evolutionary process, adaptations to this intrinsic pressure include not only a variety of familiar genetic mechanisms but also many anatomical and life-style characteristics that focus on the transmission of information between generations. 
