
TY  - JOUR
A1  - Ramsay, RG 
A1  - Westerman, M 
T1  - X-ray Induced Activity of N-Ethylmaleimide-Sensitive DNA Polymerase in Chinese Hamster Cells
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1980
VL  - 33
IS  - 4
SP  - 423
EP  - 430
KW  - 
UR  - https://doi.org/10.1071/BI9800423 
N2  - Chinese hamster DDN cells have been exposed to low doses of X-irradiation « 15 Gy). These doses have been shown to induce significant levels of repair replication. Levels of activity of DNA polymerase were subsequently measured in cells exposed in G 1 phase of mitosis to 7·5 Gy of X-rays. Following exposure, the activity of this enzyme was observed to rise to a peak within 15 min postirradiation, then decline and then rise again over a long period. The initial rise at least was found to be sensitive to inhibition by N-ethylmaleimide, a known inhibitor of DNA polymerase-o< and DNA polymerase-y at the concentration used. It is therefore suggested that repair of X-ray-induced damage in these DON cells was at least in part dependent upon induced DNA polymerase activity and this may involve DNA polymerase-o< or DNA polymerase-y, or both. 
ER  -

