
TY  - JOUR
A1  - M Clark, Julian 
T1  - Mutagenicity of DDT in Mice, Drosophila melanogaster and Neurospora crassa
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1974
VL  - 27
IS  - 4
SP  - 427
EP  - 440
KW  - 
UR  - https://doi.org/10.1071/BI9740427 
N2  - The pesticide DDT was examined for possible mutagenicity in mice, D. melanogaster and N. crassa. Through the use of the dominant-lethal assay it was found that acute oral doses of DDT (2 x 150 mg/kg body weight) in male mice induced dominant lethal mutations in early spermatid and spermato-cyte stages. Chronic oral doses of DDT (2 x 100 mg/kg body weight per week for 10 weeks) in male mice caused a persistent increase in the number of dominant lethal mutations. Histological sections showed that chronic treatment of mice with DDT caused changes in seminiferous tubule morphology and degeneration of B-type spermatogonia. Acute treatment of mice with DDT caused an increase in spermatocyte chromosome breakage, stickiness and precocious separation of the X and Y bivalent. 
ER  -

