
TY  - JOUR
A1  - Williams, JF 
A1  - Irving, MG 
A1  - Blackmore, PF 
A1  - Regtop, HL 
A1  - Clark, MG 
T1  - The Acute Biochemical Response of the Starved Rabbit Liver in Situ to Glucose Infusion
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1974
VL  - 27
IS  - 3
SP  - 249
EP  - 258
KW  - 
UR  - https://doi.org/10.1071/BI9740249 
N2  - Increasing the blood glucose levels from 88 to 400 mg/IOO ml in rabbit liver in situ during 5-min time intervals resulted in a decrease in the production of C02 from C-I of liver glucose together with a slight increase in the oxidation of C-6 of glucose; this was caused by a high glucose-induced decrease in the activity of the oxidative pentose phosphate pathway. Increasing the glucose concentrations also resulted in a threefold increase in the levels of palmitoyl- and stearoyl-CoA esters at a glucose load of 0·8 g; this is consistent with a specific feed-back inhibition of the production of NADPH by reactions of the oxidative pentose phosphate pathway by long-chain fatty acyl-CoAs. A decrease in plasma free fatty acids occurred when blood glucose levels were raised; this was associated with an increase in the concentration of free fatty acids in liver. 
ER  -

