
TY  - JOUR
A1  - Catcheside, DG 
A1  - Angel, Teresa 
T1  - A Histidine-3 Mutant, in Neurospora crassa, due to an Interchange
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1974
VL  - 27
IS  - 2
SP  - 219
EP  - 230
KW  - 
UR  - https://doi.org/10.1071/BI9740219 
N2  - The his-3 mutant TM429, which has an absolute requirement for histidine, appears to be due to a break in the his-3+ gene just distal to the site of K874. In consequence the proximal three-quarters of the his-3 gene is separated from the distal quarter and from the cog locus, between his-3 and ad-3, at or near which most recombination in this region is initiated. The original stock of TM429 carried cog+. Allelic recombination between TM429 and his-3 genes with sites of difference proximal to TM429 is unaffected by the substitution of rec-2 for rec-2+, unless cog+ is also present in the second parent. Allelic recombination between TM429 and his-3 genes with sites of difference distal to TM429 is increased by rec-2, as also is non-allelic recombination between TM429 and ad-3, irrespective of whether cog+ or cog is in the second parent. The data are explicable if cog+ is very strongly competitive as the site for initiating recombination and if a recombination event running towards his-3 is not also established at once in the cog chromosome. 
ER  -

