
TY  - JOUR
A1  - Springell, PH 
T1  - Nucleic Acids and the Biosynthesis of Collagen
JF  - Australian Journal of Biological Sciences
JO  - Aust. Jnl. Of Bio. Sci.
Y1  - 1957
VL  - 10
IS  - 3
SP  - 398
EP  - 406
KW  - 
UR  - https://doi.org/10.1071/BI9570398 
N2  - The study of skin protein fractions obtained by salt fractionation indicates that collagen is associated to a greater extent with the ribonucleoprotein fraction than with the deoxyribonucleoprotein fraction. The gelatin derived from the ribonucleoprotein fraction following in vitro incubation of foetal lambskin in the presence of glycine-2-14C was appreciably radioactive. Pre-treatment of the skin with crystalline ribonuclease resulted in a marked inhibition of glycine incorporation into total gelatin. whereas crystalline deoxyribonuclease had little effect. It is therefore concluded that ribonucleic acid rather than deoxyribonucleic acid is associated with the biosynthesis of collagen. 
ER  -

