Pancreatic Response of Anaesthetized and Conscious Rats to Bolus Injection of Cholecystokinin-Pancreozymin

Abstract

Pancreatic secretion was studied in anaesthetized rats tested immediately after surgery or in conscious rats tested 48 h after the cannulation of the pancreatic duct. Pancreatic flow, protein output and enzyme output were measured over a 30-min period in the unstimulated state and after the intravenous injection of bolus doses of cholecystokinin-pancreozymin (CCK-PZ) ranging from 1·25 to 20 Crick-Harper-Raper units (CHRU). Each animal received three doses of CCK-PZ, as either ascending or descending doses.