Studies on the in Vitro Metabolism of [3H]Cortisol and [3H]Oestradiol by Sheep Skin and Wool Roots

Abstract

The in vitro metabolism of [3H]cortisol, [3H]cortisone and [3H]oestradiol-17 P by adult sheep skin and wool follicle tissue (wool roots) was examined. The main metabolic product of the incubation of [3H]cortisol with sheep skin was [,H]cortisone, and the conversion was reversible. Wool roots were unable to carry out detectable interconversion, nor did this tissue give rise to other significant metabolites.