The Effect of Epistasis in the Standard Two-Locus Model

Abstract

Moran (1964) proved three negative results for the standard two-locus model of population genetics: (1) that mean fitness was not a function of the allelic frequencies alone; (2) that stationary states of the population do not, in general, correspond to stationary values of the mean fitness; (3) the mean fitness of a population may decrease from one generation to the next.