Interaction of Linear Analogues of D-Glucose with the ?-Glucosidase of Stachybotrys Atra

Abstract

Certain linear analogues of D-glucose appear capable of interacting simultan-eously with both the donor and acceptor centres of the ,a-glucosidase of S. atra. In particular, it has' been shown directly that N-butyl-D-gluconamide can act as an acceptor for glucosyl transfer and indirectly, by extrapolation from the behaviour of related compounds, that it is a competitive inhibitor of the enzyme. For the generalized formula, D-glitco-CH20H(CHOH)4R, highly polar R groups lead to effective interaction with the donor centre, manifested as competitive inhibition, and less polar R groups to effective interaction with the acceptor centre.