Urinary Excretion of Creatine in the Sheep

Abstract

Creatinuria was found in normal rams, wethers, and ewes on ordinary diets. This finding emphasizes the need for caution> in interpreting urine creatine concentration or creatine to creatinine ratios used as diagnostic aids in muscular dys· trophy in sheep. No change in creatine output per 24 hr was observed when the ewes were fasted for 6 days. Values are given for the ratio creatine clearance to creatinine clearance in rams, wethers, and ewes and for creatine clearance in ewes.