The Persistence of Endometrial Cysts Induced by Oestrogen in Guinea Pigs

Abstract

Cystic glandular hyperplasia of the endometrium was induced in castrate and entire guinea pigs by injecting oestradiol (15 ~tg per week), or by feeding them oestrogenically potent subterranean clover, for 7-8 weeks. The presence of the lesion was determined by removal of one uterine horn at biopsy from some of the animals at the end of the 7-8 weeks, after which all animals were left without treatment for a further period of 20 weeks.