The Mode of Action of Phenothiazine as an Anthelmintic. The Uptake of 35S-Labelled Phenothiazine by the Tissues of Nematode Parasites and Their Hosts

Abstract

Ascaridia galli, Nippostrongylus muTis, and Haemonchus contortus took up phenothiazine in vitro at the rate of 0.12, 0.18, and 0.26 mg./g. dry wt./hour. The uptake, which was fastest at pH 6.0, was increased in the presence of a wetting agent. It was not proportional to the relative surface area/wet weight of the parasites. The ligaturing of A. galli did not appreciably reduce uptake of the drug in vitro.