Free Standard AU & NZ Shipping For All Book Orders Over $80!
Register      Login
Australian Health Review Australian Health Review Society
Journal of the Australian Healthcare & Hospitals Association
RESEARCH ARTICLE

Does policy change to allow pharmacist provision of influenza vaccination increase population uptake? A systematic review

Jean Spinks A B F , Emilie Bettington C , Martin Downes A B , Lisa Nissen D and Amanda Wheeler B E
+ Author Affiliations
- Author Affiliations

A Centre for Applied Health Economics, 1.11 N78, 170 Kessels Road, Griffith University, Nathan, Qld 4111, Australia. Email: m.downes@griffith.edu.au

B Menzies Health Institute Queensland, Griffith University, Brisbane, Qld 4111, Australia. Email: a.wheeler@griffith.edu.au

C Australian Government, Department of Health, Level 15, 160 Ann Street, Brisbane, Qld 4000, Australia. Email: Emilie.Bettington@health.gov.au

D Faculty of Health, Level 9, Q Block, Room 911, Queensland University of Technology, Brisbane, Qld 4000, Australia. Email: l.nissen@qut.edu.au

E School of Human Services and Social Work, N17 1.02, 170 Kessels Road, Griffith University, Nathan, Qld 4111, Australia.

F Corresponding author. Email: j.spinks@griffith.edu.au

Australian Health Review 44(4) 582-589 https://doi.org/10.1071/AH19196
Submitted: 09 September 2019  Accepted: 02 December 2019   Published: 17 July 2020

Abstract

Objective The aims of this study were to estimate the effect of pharmacists’ vaccinating for influenza on overall vaccination rates and to assess whether any effect differs for at-risk subgroups compared with the general population.

Methods A systematic review was undertaken, adhering to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Databases were searched during July 2019 and included Medline (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus and the Cochrane Library.

Results The largest difference reported in overall population vaccination rates associated with pharmacists undertaking influenza vaccinations was an increase of 10%; the smallest showed no discernible effect. The effect was graduated: pharmacists with the most autonomy demonstrated the largest rate increases. There was evidence of substitution by pharmacists, but the effect size was small.

Conclusions The effect of allowing pharmacists to administer influenza vaccinations appears positive, but small. Given that pharmacists are likely to provide vaccinations at a lower cost than doctors, there may be cost-savings to the health system and consumers. Future research may include evaluating pharmacist-provided vaccinations compared with (or in combination with) other strategies, such as advertising, to increase access and uptake across the range of providers, as well as ongoing research to address vaccine hesitancy.

What is known about the topic? In Australia, and many other countries, community pharmacies provide an alternative and accessible option for influenza vaccination; however the effect on overall vaccination rates remains unclear.

What does this paper add? This systematic review of the international literature suggests that pharmacist-provided vaccinations increase uptake; substitution of doctors by pharmacists may result in cost savings.

What are the implications for practitioners? The findings of this study are important for health policy makers and health workforce researchers aiming to maximise population vaccination rates and workforce efficiency. In the absence of available Australian data, data from the international experience of legislating pharmacists to vaccinate against influenza are summarised and critiqued. Results can be used when determining the best health workforce and policy mix with regard to the vaccination workforce.

Additional keywords: access to primary health care, immunisation.


References

[1]  Newall AT, Wood JG, MacIntyre CR. Influenza-related hospitalisation and death in Australians aged 50 years and older. Vaccine 2008; 26 2135–41.
Influenza-related hospitalisation and death in Australians aged 50 years and older.Crossref | GoogleScholarGoogle Scholar | 18325639PubMed |

[2]  Simonsen L. The global impact of influenza on morbidity and mortality. Vaccine 1999; 17 S3–10.
The global impact of influenza on morbidity and mortality.Crossref | GoogleScholarGoogle Scholar | 10471173PubMed |

[3]  Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, Fukuda K. Influenza-associated hospitalizations in the United States. JAMA 2004; 292 1333–40.
Influenza-associated hospitalizations in the United States.Crossref | GoogleScholarGoogle Scholar | 15367555PubMed |

[4]  Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, Fukuda K. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289 179–86.
Mortality associated with influenza and respiratory syncytial virus in the United States.Crossref | GoogleScholarGoogle Scholar | 12517228PubMed |

[5]  Australian Technical Advisory Group on Immunisation (ATAGI). The Australian Immunisation Handbook. Canberra: Australian Government Department of Health; 2018.

[6]  Molinari NAM, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, Bridges CB. The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine 2007; 25 5086–96.
The annual impact of seasonal influenza in the US: measuring disease burden and costs.Crossref | GoogleScholarGoogle Scholar |

[7]  Australian Institute of Health and Welfare (AIHW). 2009 Adult vaccination survey: summary results. Canberra: AIHW; 2011.

[8]  Lee BY, Mehrotra A, Burns RM, Harris KM. Alternative vaccination locations: who uses them and can they increase flu vaccination rates? Vaccine 2009; 27 4252–6.
Alternative vaccination locations: who uses them and can they increase flu vaccination rates?Crossref | GoogleScholarGoogle Scholar | 19406181PubMed |

[9]  Weatherill SA, Buxton JA, Daly PC. Immunization programs in non-traditional settings. Can J Public Health 2004; 95 133–7.
Immunization programs in non-traditional settings.Crossref | GoogleScholarGoogle Scholar | 15074905PubMed |

[10]  Vlahov D, Coady MH, Ompad DC, Galea S. Strategies for improving influenza immunization rates among hard-to-reach populations. J Urban Health 2007; 84 615–31.
Strategies for improving influenza immunization rates among hard-to-reach populations.Crossref | GoogleScholarGoogle Scholar | 17562184PubMed |

[11]  Ward K, Chow MYK, King C, Leask J. Strategies to improve vaccination uptake in Australia, a systematic review of types and effectiveness. Aust N Z J Public Health 2012; 36 369–77.
Strategies to improve vaccination uptake in Australia, a systematic review of types and effectiveness.Crossref | GoogleScholarGoogle Scholar |

[12]  Fletcher A, Marra F, Kaczorowski J. Pharmacists as vaccination providers: friend or foe? Can Pharm J (Ott) 2014; 147 141–2.

[13]  Hope D, Yeates G, King M. Fragmented federation: inconsistent interstate requirements for pharmacist vaccine administration. Aust J Pharm 2016; 97 18–22.

[14]  Australian Medical Association (AMA). Jabs in pharmacies wrong: AMA. 2013. Available at: https://ama.com.au/ausmed/jabs-pharmacies-wrong-ama [verified 15 August 2019].

[15]  Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009; 6 e1000100
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.Crossref | GoogleScholarGoogle Scholar | 19621072PubMed |

[16]  Khadem T, Brown J. Impact of pharmacist-administered seasonal influenza vaccinations on influenza vaccination coverage rates for adults in New York State. Pharmacotherapy 2013; 33 E231 . [Abstract]

[17]  Patel A, Marra C, Lalji F, Law M, Lester R. The impact of pharmacist-delivered vaccination on influenza immunization rates and perception in Canada: an ecological study. Value Health 2014; 17 A148
The impact of pharmacist-delivered vaccination on influenza immunization rates and perception in Canada: an ecological study.Crossref | GoogleScholarGoogle Scholar |

[18]  Downes MJ, Brennan M, Williams H, Dean RS. Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). BMJ Open 2016; 6 e011458
Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS).Crossref | GoogleScholarGoogle Scholar | 27932337PubMed |

[19]  McConeghy KW, Wing C. A national examination of pharmacy-based immunization statutes and their association with influenza vaccinations and preventive health. Vaccine 2016; 34 3463–8.
A national examination of pharmacy-based immunization statutes and their association with influenza vaccinations and preventive health.Crossref | GoogleScholarGoogle Scholar | 27219340PubMed |

[20]  McConeghy KW. The impact of pharmacy-based immunization on vaccination rates and prevalence of influenza virus. Master’s Thesis, University of Illinois at Chicago; 2014.

[21]  Grabenstein JD, Guess HA, Hartzema AG, Koch GG, Konrad TR. Effect of vaccination by community pharmacists among adult prescription recipients. Med Care 2001; 39 340–8.
Effect of vaccination by community pharmacists among adult prescription recipients.Crossref | GoogleScholarGoogle Scholar | 11329521PubMed |

[22]  Steyer TE, Ragucci KR, Pearson WS, Mainous AG. The role of pharmacists in the delivery of influenza vaccinations. Vaccine 2004; 22 1001–6.
The role of pharmacists in the delivery of influenza vaccinations.Crossref | GoogleScholarGoogle Scholar | 15161077PubMed |

[23]  Drozd EM, Miller L, Johnsrud M. Impact of pharmacist immunization authority on seasonal influenza immunization rates across states. Clin Ther 2017; 39 1563–1580.e17.
Impact of pharmacist immunization authority on seasonal influenza immunization rates across states.Crossref | GoogleScholarGoogle Scholar | 28781217PubMed |

[24]  Warner JG, Portlock J, Smith J, Rutter P. Increasing seasonal influenza vaccination uptake using community pharmacies: experience from the Isle of Wight, England. Int J Pharm Pract 2013; 21 362–7.
Increasing seasonal influenza vaccination uptake using community pharmacies: experience from the Isle of Wight, England.Crossref | GoogleScholarGoogle Scholar | 23581450PubMed |

[25]  Atkins K, van Hoek AJ, Watson C, Baguelin M, Choga L, Patel A, Raj T, Jit M, Griffiths U. Seasonal influenza vaccination delivery through community pharmacists in England: evaluation of the London pilot. BMJ Open 2016; 6 e009739
Seasonal influenza vaccination delivery through community pharmacists in England: evaluation of the London pilot.Crossref | GoogleScholarGoogle Scholar | 26883237PubMed |

[26]  Deslandes R, Evans A, Baker S, Hodson K, Mantzourani E, Price K, Way C, Hughes L. Community pharmacists at the heart of public health: a longitudinal evaluation of the community pharmacy influenza vaccination service. Res Social Adm Pharm 2020; 16 497–502.
Community pharmacists at the heart of public health: a longitudinal evaluation of the community pharmacy influenza vaccination service.Crossref | GoogleScholarGoogle Scholar | 31262643PubMed |

[27]  Isenor JE. Impact of pharmacists as immunizers on influenza vaccination coverage in Nova Scotia, Canada. Hum Vaccin Immunother 2016; 12 1225–8.
Impact of pharmacists as immunizers on influenza vaccination coverage in Nova Scotia, Canada.Crossref | GoogleScholarGoogle Scholar | 26863888PubMed |

[28]  Isenor JE, Billard BA, McNeil SA, MacDougall D, Halperin BA, Slayter KL, Bowles SK. Impact of pharmacists as immunizers on influenza vaccination coverage in the community-setting in Nova Scotia, Canada: 2013–2015. J Pharm Policy Pract 2016; 9 32
Impact of pharmacists as immunizers on influenza vaccination coverage in the community-setting in Nova Scotia, Canada: 2013–2015.Crossref | GoogleScholarGoogle Scholar | 27777781PubMed |

[29]  Buchan SA, Rosella LC, Finkelstein M, Juurlink D, Isenor J, Marra F, Patel A, Russell ML, Quach S, Waite N, Kwong JC, Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) Program Delivery and Evaluation Group Impact of pharmacist administration of influenza vaccines on uptake in Canada. CMAJ 2017; 189 E146–52.
Impact of pharmacist administration of influenza vaccines on uptake in Canada.Crossref | GoogleScholarGoogle Scholar | 27503864PubMed |

[30]  Isenor JE, Edwards NT, Alia TA, Slayter KL, MacDougall DM, McNeil SA, Bowles SK. Impact of pharmacists as immunizers on vaccination rates: a systematic review and meta-analysis. Vaccine 2016; 34 5708–23.
Impact of pharmacists as immunizers on vaccination rates: a systematic review and meta-analysis.Crossref | GoogleScholarGoogle Scholar | 27765379PubMed |

[31]  Public Health Agency of Canada. Final report to outcomes from the National Consensus Conference for Vaccine-Preventable Diseases in Canada. 2008. Available at: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/08pdf/34s2-eng.pdf [verified 17 August 2019].

[32]  Centres for Disease Control and Prevention. FluVaxView objectives, targets, and indicators. 2019. Available at: https://www.cdc.gov/flu/fluvaxview/objectives.htm [verified 17 August 2019].

[33]  Hattingh HL, Sim TF, Parsons R, Czarniak P, Vickery A, Ayadurai S. Evaluation of the first pharmacist-administered vaccinations in Western Australia: a mixed-methods study. BMJ Open 2016; 6 e011948
Evaluation of the first pharmacist-administered vaccinations in Western Australia: a mixed-methods study.Crossref | GoogleScholarGoogle Scholar | 27650763PubMed |

[34]  MacDonald NE. Vaccine hesitancy: definition, scope and determinants. Vaccine 2015; 33 4161–4.
Vaccine hesitancy: definition, scope and determinants.Crossref | GoogleScholarGoogle Scholar | 25896383PubMed |

[35]  Larson HJ, Jarrett C, Eckersberger E, Smith D, Paterson P. Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007–2012. Vaccine 2014; 32 2150–9.
Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007–2012.Crossref | GoogleScholarGoogle Scholar | 24598724PubMed |

[36]  Jarrett C, Wilson R, O’Leary M, Eckersberger E, Larson HJ, SAGE Working Group on Vaccine Hesitancy Strategies for addressing vaccine hesitancy – a systematic review. Vaccine 2015; 33 4180–90.
Strategies for addressing vaccine hesitancy – a systematic review.Crossref | GoogleScholarGoogle Scholar | 25896377PubMed |