341. STUDY OF APHRODISIAC DRUG ACID PHOS ON MALE ALBINO RAT

Abstract

The male albino rat, Rattus norvegicus maintained in the laboratory by supplying regularly food and water. Acid phos is a well known aphrodisiac drug from homeopathy medical system. Doses of 200 gm of 30 number globules made from sugar of milk and moistened by 15 mL of acid phos (H₃PO₃) of 6 potency. Group-I, II and III experimental rats were carried out for 15, 30, and 15 day recovery period respectively. Appreciable behavioral changes and changes in the body weights were noticed. In 15, 30 and in 15 days of recovery period, the acid phosphatase, SGOT and albumin were significant (P < 0.05) while alkaline phosphatase, SGPT, cholesterol, glucose, total proteins and globulin was found non-significant but A : G ratio was increased significantly in 30 days of treatment. The weight of liver, kidney, and testis has found linear increased relationship with the body weight but significant (P < 0.050) increased in the weight of seminal vesicle and body weight in the experimental rat. Various histo-architectural changes were observed in the tissues of liver, kidney, testis and seminal vesicle. Both liver and kidney showed degenerative changes after 15 and 30 days .Tetraploid stages of liver pernchymal cells were predominant in the experimental rats while in 15 days of recovery period, both attained the recovery. In 30 days, the diameter of seminiferous tubules is markedly reduced, with thin unfolded mucosa. In 15 days of administration of acid phos, the intertubular spaces between the seminiferous tubule were also reduced. The number of spermatids was increased in recovery period, the testis showed the recovery. In 15 days of administration, the secretion in the lumen of seminal vesicles increased related with the structure of the epithelium of seminal vesicles while in 15 days of recovery period, the seminal vesicles showed recovery of secretory activities with pseudostratified epithelium. All the results are discussed detailed in paper.