Selected plant extracts and female fertility: role in the regulation of the hypothalamo-pituitary-ovarian axis in normal and pathological conditions

Apostolova S, Oreshkova T, Uzunova V, Georgieva I, Maslenkova L, Tzoneva R (2023) A standardized extract of Petasites hybridus L., containing the active ingredients petasins, acts as a pro-oxidant and triggers apoptosis through elevating of NF-κB in a highly invasive human breast cancer cell line. Frontiers in Bioscience-Landmark 28, 111.
| Crossref | Google Scholar |

Arabameri A, Sameni H, Bandegi A (2017) The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress. International Journal of Reproductive BioMedicine 15(8), 509-520.
| Google Scholar | PubMed |

Bai G-L, Hu K-L, Huan Y, Wang X, Lei L, Zhang M, Guo C-Y, Chang H-S, Zhao L-B, Liu J, Shen Z-F, Wang X-L, Ni X (2021) The traditional chinese medicine fuyou formula alleviates precocious puberty by inhibiting GPR54/GnRH in the hypothalamus. Frontiers in Pharmacology 11, 596525.
| Crossref | Google Scholar | PubMed |

Balen A, Rajkowha M (2003) Polycystic ovary syndrome—a systemic disorder? Best Practice & Research Clinical Obstetrics & Gynaecology 17(2), 263-274.
| Crossref | Google Scholar | PubMed |

Banik B, Roy S, Paul S, Reang M, Das T, Majumdar K, Baishnab B, Sarma D, Debbarma S, Mitra S, Datta BK (2023) Habitat characterizations and suitability analysis for conservation implications of Gymnosphaera gigantea (Wall. ex Hook.) S.Y.Dong: a threatened tree fern. Arabian Journal of Geosciences 16, 414.
| Crossref | Google Scholar |

Barbe A, Mellouk N, Ramé C, Grandhaye J, Staub C, Venturi E, Cirot M, Petit A, Anger K, Chahnamian M, Ganier P, Callut O, Cailleau-Audouin E, Metayer-Coustard S, Riva A, Froment P, Dupont J (2020) A grape seed extract maternal dietary supplementation in reproductive hens reduces oxidative stress associated to modulation of plasma and tissue adipokines expression and improves viability of offsprings. PLoS ONE 15(4), e0231131.
| Crossref | Google Scholar |

Basini G, Bianco F, Grasselli F (2005) Epigallocatechin-3-gallate from green tea negatively affects swine granulosa cell function. Domestic Animal Endocrinology 28(3), 243-256.
| Crossref | Google Scholar | PubMed |

Bennetau-Pelissero C, Kaushik S, Sumpter J, Fostier A, Le Gac F, Valotaire Y, Davail-Cuisset B, Le Menn F (1998) Effets du soja et des phyto-oestrogènes sur la vitellogénèse et l’endocrinologie stéroïdienne de la truite arc-en-ciel et de l’esturgeon sibérien. Approches in vivo et in vitro. Bulletin Français de la Pêche et de la Pisciculture (350–351), 571–583. 10.1051/kmae:1998026

Benot-Dominguez R, Tupone MG, Castelli V, d’Angelo M, Benedetti E, Quintiliani M, Cinque B, Forte IM, Cifone MG, Ippoliti R, Barboni B, Giordano A, Cimini A (2021) Olive leaf extract impairs mitochondria by pro-oxidant activity in MDA-MB-231 and OVCAR-3 cancer cells. Biomedicine & Pharmacotherapy 134, 111139.
| Crossref | Google Scholar | PubMed |

Broadhead GK, Chang A, Grigg J, McCluskey P (2016) Efficacy and safety of saffron supplementation: current clinical findings. Critical Reviews in Food Science and Nutrition 56(16), 2767-2776.
| Crossref | Google Scholar | PubMed |

Cai Y, Liu Y, Liu Z, Zhang F, Xiang F, Xia G (2009) High-frequency embryogenesis and regeneration of plants with high content of gentiopicroside from the Chinese medicinal plant Gentiana straminea Maxim. In Vitro Cellular & Developmental Biology – Plant 45, 730-739.
| Crossref | Google Scholar |

Cai J, Hu Q, He Z, Chen X, Wang J, Yin X, Ma X, Zeng J (2023) Scutellaria baicalensis Georgi and their natural flavonoid compounds in the treatment of ovarian cancer: a review. Molecules 28(13), 5082.
| Crossref | Google Scholar | PubMed |

Chan W-H (2006) Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts. Human Reproduction 21(11), 2985-2995.
| Crossref | Google Scholar | PubMed |

Chiavaroli A, Di Simone SC, Acquaviva A, Nilofar N, Libero ML, Brunetti L, Recinella L, Leone S, Orlando G, Zengin G, Di Vito M, Menghini L, Ferrante C (2024) Neuromodulatory effects induced by the association of Moringa oleifera lam., Tribulus terrestris L., Rhodiola rosea Lam., and Undaria pinnatidifida extracts in the hypothalamus. Chemistry & Biodiversity 21(5), e202302075.
| Crossref | Google Scholar | PubMed |

Dailiah Roopha P, Padmalatha C (2012) Effect of herbal preparation on heavy metal (cadmium) induced antioxidant system in female wistar rats. Journal of Medical Toxicology 8, 101-107.
| Crossref | Google Scholar | PubMed |

Davis SR, Baber RJ (2022) Treating menopause—MHT and beyond. Nature Reviews Endocrinology 18, 490-502.
| Crossref | Google Scholar | PubMed |

De Araújo FF, De Paulo Farias D, Neri-Numa IA, Pastore GM (2021) Polyphenols and their applications: an approach in food chemistry and innovation potential. Food Chemistry 338, 127535.
| Crossref | Google Scholar | PubMed |

Düker E-M, Kopanski L, Jarry H, Wuttke W (1991) Effects of extracts from Cimicifuga racemosa on gonadotropin release in menopausal women and ovariectomized rats. Planta Medica 57(5), 420-424.
| Crossref | Google Scholar | PubMed |

Farahbod F, Soureshjani SH (2018) Medecinal Herbs affecting gonadotropin hormones in women: an updated systematic review. International Journal of Pharmaceutical Sciences and Research 8, 53-57.
| Google Scholar |

Harrison JE, Weber S, Jakob R, Chute CG (2021) ICD-11: an international classification of diseases for the twenty-first century. BMC Medical Informatics and Decision Making 21, 206.
| Crossref | Google Scholar | PubMed |

Hassanein EM, Szelényi Z, Szenci O (2024) Gonadotropin-releasing hormone (GnRH) and its agonists in bovine reproduction I: structure, biosynthesis, physiological effects, and its role in estrous synchronization. Animals 14(10), 1473.
| Crossref | Google Scholar | PubMed |

Hedayat KM, Lapraz J-C (2019) Menstrual cycle disorders. ‘The theory of endobiogeny’. (Ed. J-C Lapraz) pp. 89–122. (Elsevier: San Diego, CA, USA) 10.1016/B978-0-12-816964-3.00005-5

Heidary M, Yazdanpanahi Z, Dabbaghmanesh M, Parsanezhad ME, Emamghoreishi M, Akbarzadeh M (2018) Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome. Journal of Research in Medical Sciences 23(1), 33.
| Crossref | Google Scholar | PubMed |

Hou F, Xiao M, Li J, Cook DW, Zeng W, Zhang C, Mi Y (2016) Ameliorative effect of grape seed proanthocyanidin extract on cadmium-induced meiosis inhibition during oogenesis in chicken embryos. The Anatomical Record 299(4), 450-460.
| Crossref | Google Scholar |

Hsia S-M, Yeh C-L, Kuo Y-H, Wang PS, Chiang W (2007) Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro. Experimental Biology and Medicine 232(9), 1181-1194.
| Crossref | Google Scholar |

Hu Q, Jin J, Zhou H, Yu D, Qian W, Zhong Y, Zhang J, Tang C, Liu P, Zhou Y, Wang X, Sheng L (2018) Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons. Biomedicine & Pharmacotherapy 107, 1363-1369.
| Crossref | Google Scholar | PubMed |

Hyun J-Y, Jung H-S, Park J-Y (2024) Herbal therapeutics for female infertility: a systematic review and meta-analysis. Journal of Ethnopharmacology 319, 117258.
| Crossref | Google Scholar | PubMed |

Izaguirre-Carbonell J, Kawakubo H, Murata H, Tanabe A, Takeuchi T, Kusayanagi T, Tsukuda S, Hirakawa T, Iwabata K, Kanai Y, Ohta K, Miura M, Sakaguchi K, Matsunaga S, Sahara H, Kamisuki S, Sugawara F (2015) Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity. Scientific Reports 5, 15136.
| Crossref | Google Scholar |

Jiang W, Qiu W, Wang Y, Cong Q, Edwards D, Ye B, Xu C (2011) Ginkgo may prevent genetic-associated ovarian cancer risk multiple biomarkers and anticancer pathways induced by ginkgolide B in BRCA1-mutant ovarian epithelial cells. European Journal of Cancer Prevention 20(6), 508-517.
| Crossref | Google Scholar | PubMed |

Jiang X-L, Tai H, Kuang J-S, Zhang J-Y, Cui S-C, Lu Y-X, Qi S-B, Zhang S-Y, Li S-M, Chen J-P, Meng X-S (2023) Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF. Aging 15(6), 2358-2360.
| Crossref | Google Scholar | PubMed |

Joham AE, Teede HJ, Ranasinha S, Zoungas S, Boyle J (2015) Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: data from a large community-based cohort study. Journal of Women’s Health 24(4), 299-307.
| Crossref | Google Scholar |

Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP (2004) Stress and the female reproductive system. Journal of Reproductive Immunology 62(1), 61-68.
| Crossref | Google Scholar | PubMed |

Kang J-T, Moon JH, Choi J-Y, Park SJ, Kim SJ, Saadeldin IM, Lee BC (2016) Effect of antioxidant flavonoids (quercetin and taxifolin) on in vitro maturation of porcine oocytes. Asian-Australasian Journal of Animal Sciences 29(3), 352-358.
| Crossref | Google Scholar | PubMed |

Karimian M, Zandi M, Sanjabi MR, Masoumian M, Ofoghi H (2018) Effects of grape seed extract, quercetin and vitamin C on ovine oocyte maturation and subsequent embryonic development. Cellular and Molecular Biology 64, 98-102.
| Crossref | Google Scholar | PubMed |

Kataria H, Gupta M, Lahkman S, Kaur G (2015) Withania somnifera aqueous extract facilitates the expression and release of GnRH: in vitro and in vivo study. Neurochemistry International 89, 111-119.
| Crossref | Google Scholar |

Kazemijaliseh H, Ramezani Tehrani F, Behboudi-Gandevani S, Hosseinpanah F, Khalili D, Azizi F (2015) The prevalence and causes of primary infertility in iran: a population-based study. Global Journal of Health Science 7(6), 226-232.
| Crossref | Google Scholar | PubMed |

Kou M-J, Ding X, Chen J-X, Liu Y, Liu Y-Y (2016) Traditional chinese medicine combined with hormone therapy to treat premature ovarian failure: a meta-analysis of randomized controlled trials. African Journal of Traditional, Complementary and Alternative Medicines 13(5), 160-169.
| Crossref | Google Scholar | PubMed |

Lakshmi JN, Babu AN, Kiran SSM, Nori LP, Hassan N, Ashames A, Bhandare RR, Shaik AB (2023) Herbs as a source for the treatment of polycystic ovarian syndrome: a systematic review. BioTech 12(1), 4.
| Crossref | Google Scholar | PubMed |

Lephart ED (2015) Modulation of aromatase by phytoestrogens. Enzyme Research 2015, 1-11.
| Crossref | Google Scholar |

Lheureux S, Braunstein M, Oza AM (2019) Epithelial ovarian cancer: evolution of management in the era of precision medicine. CA: a Cancer Journal for Clinicians 69(4), 280-304.
| Crossref | Google Scholar | PubMed |

Li Q, Zhang Y, Li W, Yan K, Liu Y, Xu H, Lu Y, Liang X, Yang X (2022) Allicin protects porcine oocytes against LPS-induced defects during maturation in vitro. Theriogenology 182, 138-147.
| Crossref | Google Scholar | PubMed |

Lin J, Li X-L, Song H, Li Q, Wang M-Y, Qiu X-M, Li D-J, Wang L (2017) A general description for Chinese medicine in treating premature ovarian failure. Chinese Journal of Integrative Medicine 23, 91-97.
| Crossref | Google Scholar | PubMed |

Liu X, Lin X, Mi Y, Li J, Zhang C (2018a) Grape seed proanthocyanidin extract prevents ovarian aging by inhibiting oxidative stress in the hens. Oxidative Medicine and Cellular Longevity 2018, 9390810.
| Crossref | Google Scholar |

Liu X, Lin X, Zhang S, Guo C, Li J, Mi Y, Zhang C (2018b) Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway. Aging 10(8), 2016-2036.
| Crossref | Google Scholar | PubMed |

Luo LL, Huang J, Fu YC, Xu JJ, Qian YS (2008) Effects of tea polyphenols on ovarian development in rats. Journal of Endocrinological Investigation 31(12), 1110-1118.
| Crossref | Google Scholar | PubMed |

Luo D, Zhang J-B, Li S-P, Liu W-R, Yao X-R, Guo H, Jin Z-L, Jin Y-X, Yuan B, Jiang H, Kim N-H (2020) Imperatorin ameliorates the aging-associated porcine oocyte meiotic spindle defects by reducing oxidative stress and protecting mitochondrial function. Frontiers in Cell and Developmental Biology 8, 592433.
| Crossref | Google Scholar | PubMed |

Maliar T, Maliarová M, Blažková M, Kunštek M, Uváčková Ľ, Viskupičová J, Purdešová A, Beňovič P (2023) Simultaneously determined antioxidant and pro-oxidant activity of randomly selected plant secondary metabolites and plant extracts. Molecules 28(19), 6890.
| Crossref | Google Scholar | PubMed |

Nagy AM, Abdelhameed MF, Elkarim ASA, Sarker TC, Abd-ElGawad AM, Elshamy AI, Hammam AM (2024) Enhancement of female rat fertility via ethanolic extract from Nigella sativa L. (black cumin) seeds assessed via HPLC–ESI–MS/MS and molecular docking. Molecules 29, 735.
| Crossref | Google Scholar | PubMed |

Ombelet W, Cooke I, Dyer S, Serour G, Devroey P (2008) Infertility and the provision of infertility medical services in developing countries. Human Reproduction Update 14(6), 605-621.
| Crossref | Google Scholar | PubMed |

Orisaka M, Tajima K, Tsang BK, Kotsuji F (2009) Oocyte-granulosa-theca cell interactions during preantral follicular development. Journal of Ovarian Research 2, 9.
| Crossref | Google Scholar | PubMed |

Pasquier J, Kamech N, Lafont A-G, Vaudry H, Rousseau K, Dufour S (2014) Molecular evolution of GPCRS: kisspeptin/kisspeptin receptors. Journal of Molecular Endocrinology 52(3), T101-T117.
| Crossref | Google Scholar | PubMed |

Peroni RN, Abramoff T, Neuman I, Podestá EJ, Adler-Graschinsky E (2012) Phytoestrogens enhance the vascular actions of the endocannabinoid anandamide in mesenteric beds of female rats. International Journal of Hypertension 2012(1), 647856.
| Crossref | Google Scholar |

Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M (2012) Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews 92(3), 1235-1316.
| Crossref | Google Scholar | PubMed |

Pizzorno J (2018) Environmental toxins and infertility. Integrative Medicine (Encinitas, Calif.) 17(3), 8-11.
| Google Scholar |

Ramos RR, Gutiérrez GR, Monroy IA, Sánchez HGM (2008) Risk factors associated to female infertility. Ginecologia y Obstetricia de Mexico 76(12), 717-721.
| Google Scholar |

Reddy PS, Begum N, Mutha S, Bakshi V (2016) Beneficial effect of curcumin in letrozole induced polycystic ovary syndrome. Asian Pacific Journal of Reproduction 5(3), 116-122.
| Crossref | Google Scholar |

Richards JS (2001) Perspective: the ovarian follicle—a perspective in 2001. Endocrinology 142(6), 2184-93.
| Crossref | Google Scholar |

Roychoudhury S, Halenar M, Michalcova K, Nath S, Kacaniova M, Kolesarova A (2018) Green tea extract affects porcine ovarian cell apoptosis. Reproductive Biology 18(1), 94-98.
| Crossref | Google Scholar | PubMed |

Schweizer RAS, Atanasov AG, Frey BM, Odermatt A (2003) A rapid screening assay for inhibitors of 11β-hydroxysteroid dehydrogenases (11β-HSD): flavanone selectively inhibits 11β-HSD1 reductase activity. Molecular and Cellular Endocrinology 212(1–2), 41-49.
| Crossref | Google Scholar | PubMed |

Shah MA, Hamid A, Faheem HI, Rasul A, Baokbah TAS, Haris M, Yousaf R, Saleem U, Iqbal S, Alves MS, Khan Z, Hussain G, Alsharfi I, Khan H, Jeandet P (2022) Uncovering the anticancer potential of polydatin: a mechanistic insight. Molecules 27(21), 7175.
| Crossref | Google Scholar | PubMed |

Shiao N-H, Chan W-H (2009) Injury effects of ginkgolide B on maturation of mouse oocytes, fertilization, and fetal development in vitro and in vivo. Toxicology Letters 188(1), 63-69.
| Crossref | Google Scholar | PubMed |

Sirotkin AV, Štochmaľová A, Alexa R, Kádasi A, Bauer M, Grossmann R, Alrezaki A, Alwasel S, Harrath AH (2019) Quercetin directly inhibits basal ovarian cell functions and their response to the stimulatory action of FSH. European Journal of Pharmacology 860, 172560.
| Crossref | Google Scholar | PubMed |

Skorupskaite K, George JT, Anderson RA (2014) The kisspeptin–GnRH pathway in human reproductive health and disease. Human Reproduction Update 20(4), 485-500.
| Crossref | Google Scholar | PubMed |

Tabuti JRS, Lye KA, Dhillion SS (2003) Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration. Journal of Ethnopharmacology 88(1), 19-44.
| Crossref | Google Scholar | PubMed |

Telefo PB, Moundipa PF, Tchouanguep FM (2004) Inductive effect of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus on in vitro production of estradiol. Journal of Ethnopharmacology 91(2–3), 225-230.
| Crossref | Google Scholar | PubMed |

Tian Z, Zhao H, Sun Y, Cai D, Chen B (2005) Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: therapeutic effects of nourishing ‘Yin’ – removing ‘Fire’ Chinese herb mixture. Reproductive Biology and Endocrinology 3, 38.
| Crossref | Google Scholar | PubMed |

Van Voorhis BJ, Dunn MS, Snyder GD, Weiner CP (1994) Nitric oxide: an autocrine regulator of human granulosa-luteal cell steroidogenesis. Endocrinology 135(5), 1799-1806.
| Crossref | Google Scholar | PubMed |

Wang F, Huang S, Chen Q, Hu Z, Li Z, Zheng P, Liu X, Li S, Zhang S, Chen J (2020) Chemical characterisation and quantification of the major constituents in the Chinese herbal formula Jian-Pi-Yi-Shen pill by UPLC–Q–TOF–MS/MS and HPLC–QQQ–MS/MS. Phytochemical Analysis 31(6), 915-929.
| Crossref | Google Scholar | PubMed |

Wang D, Chen J, Liu X, Zheng P, Song G, Yi T, Li S (2021) Retraction note: a chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats. Scientific Reports 11, 12831.
| Crossref | Google Scholar | PubMed |

Wasilewski T, Łukaszewicz-Zając M, Wasilewska J, Mroczko B (2020) Biochemistry of infertility. Clinica Chimica Acta 508, 185-190.
| Crossref | Google Scholar | PubMed |

Whitehead SA (2003) Phytoestrogens inhibit aromatase but not 17β-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17β-HSD. Human Reproduction 18(3), 487-494.
| Crossref | Google Scholar | PubMed |

Yan H, Liang C, Yang L, Li Y (2010) In vitro and ex vitro rooting of Siratia grosvenorii, a traditional medicinal plant. Acta Physiologiae Plantarum 32, 115-120.
| Crossref | Google Scholar |

Yang X, Li Y, Li Y, Ren X, Zhang X, Hu D, Gao Y, Xing Y, Shang H (2017) Oxidative stress-mediated atherosclerosis: mechanisms and therapies. Frontiers in Physiology 8, 600.
| Crossref | Google Scholar | PubMed |

Yang JX, Chaudhry MT, Yao JY, Wang SN, Zhou B, Wang M, Han CY, You Y, Li Y (2018a) Effects of phyto-oestrogen quercetin on productive performance, hormones, reproductive organs and apoptotic genes in laying hens. Journal of Animal Physiology and Animal Nutrition 102, 505-513.
| Crossref | Google Scholar |

Yang H, Lee SY, Lee SR, Pyun B-J, Kim HJ, Lee YH, Kwon SW, Suh DH, Lee CH, Hong E-J, Lee HW (2018b) Therapeutic effect of Ecklonia cava extract in letrozole-induced polycystic ovary syndrome rats. Frontiers in Pharmacology 9, 1325.
| Crossref | Google Scholar | PubMed |

Ye B, Aponte M, Dai Y, Li L, Ho M-C, Vitonis A, Edwards D, Huang T-N, Cramer DW (2007) Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Letters 251(1), 43-52.
| Crossref | Google Scholar | PubMed |

Yen G-C, Chen H-Y (1995) Antioxidant activity of various tea extracts in relation to their antimutagenicity. Journal of Agricultural and Food Chemistry 43(1), 27-32.
| Crossref | Google Scholar |

Zhang J-Q, Wang X-W, Chen J-F, Ren Q-L, Wang J, Gao B-W, Shi Z-H, Zhang Z-J, Bai X-X, Xing B-S (2019a) Grape seed procyanidin B2 protects porcine ovarian granulosa cells against oxidative stress-induced apoptosis by upregulating let-7a expression. Oxidative Medicine and Cellular Longevity 2019(1), 1076512.
| Crossref | Google Scholar |

Zhang Y, Guo J, Nie XW, Li ZY, Wang YM, Liang S, Li S (2019b) Rosmarinic acid treatment during porcine oocyte maturation attenuates oxidative stress and improves subsequent embryo development in vitro. PeerJ 7, e6930.
| Crossref | Google Scholar | PubMed |

Zhao L, Sun Q-Y, Ge Z-J (2021) Potential role of tea extract in oocyte development. Food & Function 12(21), 10311-10323.
| Crossref | Google Scholar | PubMed |