Maternal metabolic health and fertility: we should not only care about but also for the oocyte!
J. L. M. R. Leroy
A * , B. Meulders A , K. Moorkens A , I. Xhonneux A , J. Slootmans A , L. De Keersmaeker A , A. Smits A , O. Bogado Pascottini B and W. F. A. Marei A C
+ Author Affiliations
- Author Affiliations
A Gamete Research Centre, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.
B Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
C Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
* Correspondence to: jo.leroy@uantwerpen.be
Reproduction, Fertility and Development 35(2) 1-18 https://doi.org/10.1071/RD22204
Published online: 4 October 2022
© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing on behalf of the IETS
Abstract
Metabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte’s microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction play key roles in the pathogenesis. Acute effects on the fully grown oocytes are evident, but early follicular stages are also sensitive to metabolic stress leading to a long-term impact on follicular cells and oocytes. Improving the preconception health is therefore of capital importance but research in animal models has demonstrated that oocyte quality is not fully recovered. In the in vitro fertilisation clinic, maternal metabolic disorders are linked with disappointing assisted reproductive technology results. Embryos derived from metabolically compromised oocytes exhibit persistently high intracellular stress levels due to weak cellular homeostatic mechanisms. The assisted reproductive technology procedures themselves form an extra burden for these defective embryos. Minimising cellular stress during culture using mitochondrial-targeted therapy could rescue compromised embryos in a bovine model. However, translating such applications to human in vitro fertilisation clinics is not simple. It is crucial to consider the sensitive epigenetic programming during early development. Research in humans and relevant animal models should result in preconception care interventions and in vitro strategies not only aiming at improving fertility but also safeguarding offspring health.
Keywords: antioxidant, assisted reproduction, epigenetic programming, maternal metabolic health, mitochondria targeted therapy, oocyte mitochondria, oocyte quality, preconception care interventions.
References
Abdelatty, AM, Iwaniuk, ME, Potts, SB, and Gad, A (2018). Influence of maternal nutrition and heat stress on bovine oocyte and embryo development. International Journal of Veterinary Science and Medicine 6, S1–S5.| Influence of maternal nutrition and heat stress on bovine oocyte and embryo development.Crossref | GoogleScholarGoogle Scholar |
Adhikari, D, Lee, I-W, Al-Zubaidi, U, Liu, J, Zhang, Q-H, Yuen, WS, He, L, Winstanley, Y, Sesaki, H, Mann, JR, Robker, RL, and Carroll, J (2022). Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development. Science Advances 8, eabl8070.
| Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development.Crossref | GoogleScholarGoogle Scholar |
Agarwal, A, Saleh, RA, and Bedaiwy, MA (2003). Role of reactive oxygen species in the pathophysiology of human reproduction. Fertility and Sterility 79, 829–843.
| Role of reactive oxygen species in the pathophysiology of human reproduction.Crossref | GoogleScholarGoogle Scholar |
Agarwal, A, Gupta, S, Sekhon, L, and Shah, R (2008). Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxidants & Redox Signaling 10, 1375–1404.
| Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications.Crossref | GoogleScholarGoogle Scholar |
Agarwal, A, Aponte-Mellado, A, Premkumar, BJ, Shaman, A, and Gupta, S (2012). The effects of oxidative stress on female reproduction: a review. Reproductive Biology and Endocrinology 10, 49.
| The effects of oxidative stress on female reproduction: a review.Crossref | GoogleScholarGoogle Scholar |
Aksungar, FB, Sarikaya, M, Coskun, A, Serteser, M, and Unsal, I (2017). Comparison of intermittent fasting versus caloric restriction in obese subjects: a two year follow-up. The Journal of Nutrition, Health & Aging 21, 681–685.
| Comparison of intermittent fasting versus caloric restriction in obese subjects: a two year follow-up.Crossref | GoogleScholarGoogle Scholar |
Al-Katanani, YM, Paula-Lopes, FF, and Hansen, PJ (2002). Effect of season and exposure to heat stress on oocyte competence in Holstein cows. Journal of Dairy Science 85, 390–396.
| Effect of season and exposure to heat stress on oocyte competence in Holstein cows.Crossref | GoogleScholarGoogle Scholar |
Al-Zubaidi, U, Adhikari, D, Cinar, O, Zhang, Q-H, Yuen, WS, Murphy, MP, Rombauts, L, Robker, RL, and Carroll, J (2021). Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes. Human Reproduction 36, 771–784.
| Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes.Crossref | GoogleScholarGoogle Scholar |
Alves, GP, Cordeiro, FB, Bruna de Lima, C, Annes, K, Cristina dos Santos, É, Ispada, J, Fontes, PK, Nogueira, MFG, Nichi, M, and Milazzotto, MP (2019). Follicular environment as a predictive tool for embryo development and kinetics in cattle. Reproduction, Fertility and Development 31, 451–461.
| Follicular environment as a predictive tool for embryo development and kinetics in cattle.Crossref | GoogleScholarGoogle Scholar |
Amin, A, Gad, A, Salilew-Wondim, D, Prastowo, S, Held, E, Hoelker, M, Rings, F, Tholen, E, Neuhoff, C, Looft, C, Schellander, K, and Tesfaye, D (2014). Bovine embryo survival under oxidative-stress conditions is associated with activity of the NRF2-mediated oxidative-stress-response pathway. Molecular Reproduction and Development 81, 497–513.
| Bovine embryo survival under oxidative-stress conditions is associated with activity of the NRF2-mediated oxidative-stress-response pathway.Crossref | GoogleScholarGoogle Scholar |
Andersen, CJ, and Fernandez, ML (2013). Dietary strategies to reduce metabolic syndrome. Reviews in Endocrine and Metabolic Disorders 14, 241–254.
| Dietary strategies to reduce metabolic syndrome.Crossref | GoogleScholarGoogle Scholar |
Annes, K, Müller, DB, Vilela, JAP, Valente, RS, Caetano, DP, Cibin, FWS, Milazzotto, MP, Mesquita, FS, Belaz, KRA, Eberlin, MN, and Sudano, MJ (2019). Influence of follicle size on bovine oocyte lipid composition, follicular metabolic and stress markers, embryo development and blastocyst lipid content. Reproduction, Fertility and Development 31, 462–472.
| Influence of follicle size on bovine oocyte lipid composition, follicular metabolic and stress markers, embryo development and blastocyst lipid content.Crossref | GoogleScholarGoogle Scholar |
Asaadi, A, Dolatabad, NA, Atashi, H, Raes, A, Van Damme, P, Hoelker, M, Hendrix, A, Pascottini, OB, Van Soom, A, Kafi, M, and Pavani, KC (2021). Extracellular vesicles from follicular and ampullary fluid isolated by density gradient ultracentrifugation improve bovine embryo development and quality. International Journal of Molecular Sciences 22, 578.
| Extracellular vesicles from follicular and ampullary fluid isolated by density gradient ultracentrifugation improve bovine embryo development and quality.Crossref | GoogleScholarGoogle Scholar |
Baldi, A (2005). Vitamin E in dairy cows. Livestock Production Science 98, 117–122.
| Vitamin E in dairy cows.Crossref | GoogleScholarGoogle Scholar |
Baldi, A, Savoini, G, Pinotti, L, Monfardini, E, Cheli, F, and Dell Orto, V (2000). Effects of vitamin e and different energy sources on vitamin e status, milk quality and reproduction in transition cows. Journal of Veterinary Medicine Series A 47, 599–608.
| Effects of vitamin e and different energy sources on vitamin e status, milk quality and reproduction in transition cows.Crossref | GoogleScholarGoogle Scholar |
Barker, DJP (2007). The origins of the developmental origins theory. Journal of Internal Medicine 261, 412–417.
| The origins of the developmental origins theory.Crossref | GoogleScholarGoogle Scholar |
Barletta, RV, Maturana Filho, M, Carvalho, PD, Del Valle, TA, Netto, AS, Rennó, FP, Mingoti, RD, Gandra, JR, Mourão, GB, Fricke, PM, Sartori, R, Madureira, EH, and Wiltbank, MC (2017). Association of changes among body condition score during the transition period with NEFA and BHBA concentrations, milk production, fertility, and health of Holstein cows. Theriogenology 104, 30–36.
| Association of changes among body condition score during the transition period with NEFA and BHBA concentrations, milk production, fertility, and health of Holstein cows.Crossref | GoogleScholarGoogle Scholar |
Batushansky, A, Zacharia, A, Shehadeh, A, Bruck-Haimson, R, Saidemberg, D, Kogan, NM, Thomas Mannully, C, Herzberg, S, Ben-Meir, A, and Moussaieff, A (2020). A shift in glycerolipid metabolism defines the follicular fluid of IVF patients with unexplained infertility. Biomolecules 10, 1135.
| A shift in glycerolipid metabolism defines the follicular fluid of IVF patients with unexplained infertility.Crossref | GoogleScholarGoogle Scholar |
Berry, DP, Friggens, NC, Lucy, M, and Roche, JR (2016). Milk production and fertility in cattle. Annual Review of Animal Biosciences 4, 269–290.
| Milk production and fertility in cattle.Crossref | GoogleScholarGoogle Scholar |
Best, D, and Bhattacharya, S (2015). Obesity and fertility. Hormone Molecular Biology and Clinical Investigation 24, 5–10.
| Obesity and fertility.Crossref | GoogleScholarGoogle Scholar |
Boedt, T, Matthys, C, Lie Fong, S, De Neubourg, D, Vereeck, S, Seghers, J, Van der Gucht, K, Weyn, B, Geerts, D, Spiessens, C, and Dancet, EAF (2021). Systematic development of a mobile preconception lifestyle programme for couples undergoing IVF: the PreLiFe-programme. Human Reproduction 36, 2493–2505.
| Systematic development of a mobile preconception lifestyle programme for couples undergoing IVF: the PreLiFe-programme.Crossref | GoogleScholarGoogle Scholar |
Borradaile, NM, Han, X, Harp, JD, Gale, SE, Ory, DS, and Schaffer, JE (2006). Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. Journal of Lipid Research 47, 2726–2737.
| Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death.Crossref | GoogleScholarGoogle Scholar |
Bosco, D, Haefliger, J-A, and Meda, P (2011). Connexins: key mediators of endocrine function. Physiological Reviews 91, 1393–1445.
| Connexins: key mediators of endocrine function.Crossref | GoogleScholarGoogle Scholar |
Boudoures, AL, Chi, M, Thompson, A, Zhang, W, and Moley, KH (2016). The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model. Reproduction 151, 261–270.
| The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model.Crossref | GoogleScholarGoogle Scholar |
Boudoures, AL, Saben, J, Drury, A, Scheaffer, S, Modi, Z, Zhang, W, and Moley, KH (2017). Obesity-exposed oocytes accumulate and transmit damaged mitochondria due to an inability to activate mitophagy. Developmental Biology 426, 126–138.
| Obesity-exposed oocytes accumulate and transmit damaged mitochondria due to an inability to activate mitophagy.Crossref | GoogleScholarGoogle Scholar |
Britt JH (1992) Impacts of early postpartum metabolism on follicular development and fertility. In ‘American Association of bovine practitioners twenty-fourth annual conference, Orlando, Florida, USA’. (Ed. EI Williams) pp. 39–43.
Bromfield, JJ, and Sheldon, IM (2011). Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro. Endocrinology 152, 5029–5040.
| Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro.Crossref | GoogleScholarGoogle Scholar |
Bunel, A, Jorssen, EP, Merckx, E, Leroy, JL, Bols, PE, and Sirard, MA (2015). Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. Theriogenology 83, 228–237.
| Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential.Crossref | GoogleScholarGoogle Scholar |
Burton, GJ, Hempstock, J, and Jauniaux, E (2003). Oxygen, early embryonic metabolism and free radical-mediated embryopathies. Reproductive BioMedicine Online 6, 84–96.
| Oxygen, early embryonic metabolism and free radical-mediated embryopathies.Crossref | GoogleScholarGoogle Scholar |
Calsamiglia S, Rodríguez M (2012) Optimum vitamin nutrition in dairy cattle. In ‘Optimum vitamin nutrition’. (Ed. DSM Nutritional Products Ltd) pp. 335–373. (5M Publishing: UK)
Carvalho, PD, Souza, AH, Amundson, MC, Hackbart, KS, Fuenzalida, MJ, Herlihy, MM, Ayres, H, Dresch, AR, Vieira, LM, Guenther, JN, Grummer, RR, Fricke, PM, Shaver, RD, and Wiltbank, MC (2014). Relationships between fertility and postpartum changes in body condition and body weight in lactating dairy cows. Journal of Dairy Science 97, 3666–3683.
| Relationships between fertility and postpartum changes in body condition and body weight in lactating dairy cows.Crossref | GoogleScholarGoogle Scholar |
Chang, T-S, Cho, C-S, Park, S, Yu, S, Kang, SW, and Rhee, SG (2004). Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. Journal of Biological Chemistry 279, 41975–41984.
| Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria.Crossref | GoogleScholarGoogle Scholar |
Christenson, LK (2010). MicroRNA control of ovarian function. Animal Reproduction 7, 129–133.
Clarke H (2017) Control of mammalian oocyte development by interactions with the maternal follicular environment. In ‘Oocytes: maternal information and functions’. (Ed. M Kloc) pp. 17–41. (Springer International Publishing: Cham)
Cui, M, Yu, H, Wang, J, Gao, J, and Li, J (2013). Chronic caloric restriction and exercise improve metabolic conditions of dietary-induced obese mice in autophagy correlated manner without involving AMPK. Journal of Diabetes Research 2013, 852754.
| Chronic caloric restriction and exercise improve metabolic conditions of dietary-induced obese mice in autophagy correlated manner without involving AMPK.Crossref | GoogleScholarGoogle Scholar |
Dalvit, G, Llanes, SP, Descalzo, A, Insani, M, Beconi, M, and Cetica, P (2005). Effect of alpha-tocopherol and ascorbic acid on bovine oocyte in vitro maturation. Reproduction in Domestic Animals 40, 93–97.
| Effect of alpha-tocopherol and ascorbic acid on bovine oocyte in vitro maturation.Crossref | GoogleScholarGoogle Scholar |
Dattilo, M, Giuseppe, D, Ettore, C, and Ménézo, Y (2016). Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet. Journal of Assisted Reproduction and Genetics 33, 1633–1648.
| Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet.Crossref | GoogleScholarGoogle Scholar |
De Bie, J, Langbeen, A, Verlaet, A, Florizoone, F, Immig, I, Hermans, N, Bols, PEJ, and Leroy, JLMR (2014). B-carotene supplementation to non-lactating dairy cows can restore B-carotene availability in the follicular environment under negative energy balance conditions. Advances in Animal Biosciences 5, 247–255.
| B-carotene supplementation to non-lactating dairy cows can restore B-carotene availability in the follicular environment under negative energy balance conditions.Crossref | GoogleScholarGoogle Scholar |
De Bie, J, Langbeen, A, Verlaet, AAJ, Florizoone, F, Immig, I, Hermans, N, Fransen, E, Bols, PEJ, and Leroy, JLMR (2016). The effect of a negative energy balance status on β-carotene availability in serum and follicular fluid of nonlactating dairy cows. Journal of Dairy Science 99, 5808–5819.
| The effect of a negative energy balance status on β-carotene availability in serum and follicular fluid of nonlactating dairy cows.Crossref | GoogleScholarGoogle Scholar |
De Bie, J, Marei, WFA, Maillo, V, Jordaens, L, Gutierrez-Adan, A, Bols, PEJ, and Leroy, JLMR (2017). Differential effects of high and low glucose concentrations during lipolysis-like conditions on bovine in vitro oocyte quality, metabolism and subsequent embryo development. Reproduction, Fertility and Development 29, 2284–2300.
| Differential effects of high and low glucose concentrations during lipolysis-like conditions on bovine in vitro oocyte quality, metabolism and subsequent embryo development.Crossref | GoogleScholarGoogle Scholar |
De Bie, J, Proost, K, Van Loo, H, Callens, J, Bols, PEJ, Fransen, E, and Leroy, JLMR (2019). β-carotene and vitamin E in the dairy industry: blood levels and influencing factors – a case study in Flanders. Vlaams Diergeneeskundig Tijdschrift 88, 137–149.
| β-carotene and vitamin E in the dairy industry: blood levels and influencing factors – a case study in Flanders.Crossref | GoogleScholarGoogle Scholar |
De Bie, J, Smits, A, Marei, WFA, and Leroy, JLMR (2021). Capacity of Trolox to improve the development and quality of metabolically compromised bovine oocytes and embryos in vitro during different windows of development. Reproduction, Fertility and Development 33, 291–304.
| Capacity of Trolox to improve the development and quality of metabolically compromised bovine oocytes and embryos in vitro during different windows of development.Crossref | GoogleScholarGoogle Scholar |
Desmet, KLJ, Van Hoeck, V, Gagné, D, Fournier, E, Thakur, A, O’Doherty, AM, Walsh, CP, Sirard, MA, Bols, PEJ, and Leroy, JLMR (2016). Exposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts. BMC Genomics 17, 1004.
| Exposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts.Crossref | GoogleScholarGoogle Scholar |
Desmet, KLJ, Marei, WFA, Richard, C, Sprangers, K, Beemster, GTS, Meysman, P, Laukens, K, Declerck, K, Vanden Berghe, W, Bols, PEJ, Hue, I, and Leroy, JLMR (2020). Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts: novel insights from a bovine embryo-transfer model. Human Reproduction 35, 293–307.
| Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts: novel insights from a bovine embryo-transfer model.Crossref | GoogleScholarGoogle Scholar |
Diakogiannaki, E, Welters, HJ, and Morgan, NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids. Journal of Endocrinology 197, 553–563.
| Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids.Crossref | GoogleScholarGoogle Scholar |
Dickson, MJ, Piersanti, RL, Ramirez-Hernandez, R, de Oliveira, EB, Bishop, JV, Hansen, TR, Ma, Z, Jeong, KCC, Santos, JEP, Sheldon, MI, Block, J, and Bromfield, JJ (2020). Experimentally induced endometritis impairs the developmental capacity of bovine oocytesdagger. Biology of Reproduction 103, 508–520.
| Experimentally induced endometritis impairs the developmental capacity of bovine oocytesdagger.Crossref | GoogleScholarGoogle Scholar |
Diskin, MG, Parr, MH, and Morris, DG (2011). Embryo death in cattle: an update. Reproduction, Fertility and Development 24, 244–251.
| Embryo death in cattle: an update.Crossref | GoogleScholarGoogle Scholar |
Eichenlaub-Ritter, U, Vogt, E, Yin, H, and Gosden, R (2004). Spindles, mitochondria and redox potential in ageing oocytes. Reproductive BioMedicine Online 8, 45–58.
| Spindles, mitochondria and redox potential in ageing oocytes.Crossref | GoogleScholarGoogle Scholar |
Einarsson, S, Bergh, C, Friberg, B, Pinborg, A, Klajnbard, A, Karlström, P-O, Kluge, L, Larsson, I, Loft, A, Mikkelsen-Englund, A-L, Stenlöf, K, Wistrand, A, and Thurin-Kjellberg, A (2017). Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial. Human Reproduction 32, 1621–1630.
| Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial.Crossref | GoogleScholarGoogle Scholar |
Fair, T (2003). Follicular oocyte growth and acquisition of developmental competence. Animal Reproduction Science 78, 203–216.
| Follicular oocyte growth and acquisition of developmental competence.Crossref | GoogleScholarGoogle Scholar |
Fedorcsak, P, Storeng, R, Dale, PO, Tanbo, T, and Abyholm, T (2000). Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstetricia et Gynecologica Scandinavica 79, 43–48.
Feillet-Coudray, C, Fouret, G, Ebabe Elle, R, Rieusset, J, Bonafos, B, Chabi, B, Crouzier, D, Zarkovic, K, Zarkovic, N, Ramos, J, Badia, E, Murphy, MP, Cristol, JP, and Coudray, C (2014). The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol. Free Radical Research 48, 1232–1246.
| The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol.Crossref | GoogleScholarGoogle Scholar |
Fleming, TP, Velazquez, MA, Eckert, JJ, Lucas, ES, and Watkins, AJ (2012). Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. Animal Reproduction Science 130, 193–197.
| Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring.Crossref | GoogleScholarGoogle Scholar |
Fleming, TP, Watkins, AJ, Velazquez, MA, Mathers, JC, Prentice, AM, Stephenson, J, Barker, M, Saffery, R, Yajnik, CS, Eckert, JJ, Hanson, MA, Forrester, T, Gluckman, PD, and Godfrey, KM (2018). Origins of lifetime health around the time of conception: causes and consequences. The Lancet 391, 1842–1852.
| Origins of lifetime health around the time of conception: causes and consequences.Crossref | GoogleScholarGoogle Scholar |
Fulka, J, First, NL, and Moor, RM (1998). Nuclear and cytoplasmic determinants involved in the regulation of mammalian oocyte maturation. Molecular Human Reproduction 4, 41–49.
| Nuclear and cytoplasmic determinants involved in the regulation of mammalian oocyte maturation.Crossref | GoogleScholarGoogle Scholar |
Garnsworthy, PC (2004). The environmental impact of fertility in dairy cows: a modelling approach to predict methane and ammonia emissions. Animal Feed Science and Technology 112, 211–223.
| The environmental impact of fertility in dairy cows: a modelling approach to predict methane and ammonia emissions.Crossref | GoogleScholarGoogle Scholar |
Ge, Z-J, Zhang, C-L, Schatten, H, and Sun, Q-Y (2014a). Maternal diabetes mellitus and the origin of non-communicable diseases in offspring: the role of epigenetics. Biology of Reproduction 90, 139.
| Maternal diabetes mellitus and the origin of non-communicable diseases in offspring: the role of epigenetics.Crossref | GoogleScholarGoogle Scholar |
Ge, Z-J, Luo, S-M, Lin, F, Liang, Q-X, Huang, L, Wei, Y-C, Hou, Y, Han, Z-M, Schatten, H, and Sun, Q-Y (2014b). DNA methylation in oocytes and liver of female mice and their offspring: effects of high-fat-diet–induced obesity. Environmental Health Perspectives 122, 159–164.
| DNA methylation in oocytes and liver of female mice and their offspring: effects of high-fat-diet–induced obesity.Crossref | GoogleScholarGoogle Scholar |
Gebremedhn, S, Ali, A, Gad, A, Prochazka, R, and Tesfaye, D (2020). Extracellular vesicles as mediators of environmental and metabolic stress coping mechanisms during mammalian follicular development. Frontiers in Veterinary Science 7, 602043.
| Extracellular vesicles as mediators of environmental and metabolic stress coping mechanisms during mammalian follicular development.Crossref | GoogleScholarGoogle Scholar |
Gendelman, M, and Roth, Z (2012). Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence. Biology of Reproduction 87, 118.
| Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence.Crossref | GoogleScholarGoogle Scholar |
Gómez, E, Caamaño, JN, Rodríguez, A, De Frutos, C, Facal, N, and Díez, C (2006). Bovine early embryonic development and vitamin A. Reproduction in Domestic Animals 41, 63–71.
| Bovine early embryonic development and vitamin A.Crossref | GoogleScholarGoogle Scholar |
Gonçalves, DR, Leroy, JLMR, Van Hees, S, Xhonneux, I, Bols, PEJ, Kiekens, F, and Marei, WFA (2021). Cellular uptake of polymeric nanoparticles by bovine cumulus-oocyte complexes and their effect on in vitro developmental competence. European Journal of Pharmaceutics and Biopharmaceutics 158, 143–155.
| Cellular uptake of polymeric nanoparticles by bovine cumulus-oocyte complexes and their effect on in vitro developmental competence.Crossref | GoogleScholarGoogle Scholar |
Grodstein, F, Goldman, MB, and Cramer, DW (1994). Body mass index and ovulatory infertility. Epidemiology 5, 247–250.
| Body mass index and ovulatory infertility.Crossref | GoogleScholarGoogle Scholar |
Hailay, T, Hoelker, M, Poirier, M, Gebremedhn, S, Rings, F, Saeed-Zidane, M, Salilew-Wondim, D, Dauben, C, Tholen, E, Neuhoff, C, Schellander, K, and Tesfaye, D (2019). Extracellular vesicle-coupled miRNA profiles in follicular fluid of cows with divergent post-calving metabolic status. Scientific Reports 9, 12851.
| Extracellular vesicle-coupled miRNA profiles in follicular fluid of cows with divergent post-calving metabolic status.Crossref | GoogleScholarGoogle Scholar |
Hansen, PJ (2020). Implications of assisted reproductive technologies for pregnancy outcomes in mammals. Annual Review of Animal Biosciences 8, 395–413.
| Implications of assisted reproductive technologies for pregnancy outcomes in mammals.Crossref | GoogleScholarGoogle Scholar |
Hou, Y-J, Zhu, C-C, Duan, X, Liu, H-L, Wang, Q, and Sun, S-C (2016). Both diet and gene mutation induced obesity affect oocyte quality in mice. Scientific Reports 6, 18858.
| Both diet and gene mutation induced obesity affect oocyte quality in mice.Crossref | GoogleScholarGoogle Scholar |
Igosheva, N, Abramov, AY, Poston, L, Eckert, JJ, Fleming, TP, Duchen, MR, and McConnell, J (2010). Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS ONE 5, e10074.
| Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.Crossref | GoogleScholarGoogle Scholar |
Ikeda, S, Kitagawa, M, Imai, H, and Yamada, M (2005). The roles of vitamin A for cytoplasmic maturation of bovine oocytes. Journal of Reproduction and Development 51, 23–35.
| The roles of vitamin A for cytoplasmic maturation of bovine oocytes.Crossref | GoogleScholarGoogle Scholar |
Iossa, S, Mollica, MP, Lionetti, L, Crescenzo, R, Botta, M, and Liverini, G (2002). Skeletal muscle oxidative capacity in rats fed high-fat diet. International Journal of Obesity 26, 65–72.
| Skeletal muscle oxidative capacity in rats fed high-fat diet.Crossref | GoogleScholarGoogle Scholar |
Jensen, MD, Ryan, DH, Apovian, CM, Ard, JD, Comuzzie, AG, Donato, KA, et al. (2014). 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society. Circulation 129, S102–S138.
| 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society.Crossref | GoogleScholarGoogle Scholar |
Jungheim, ES, and Moley, KH (2010). Current knowledge of obesity’s effects in the pre- and periconceptional periods and avenues for future research. American Journal of Obstetrics and Gynecology 203, 525–530.
| Current knowledge of obesity’s effects in the pre- and periconceptional periods and avenues for future research.Crossref | GoogleScholarGoogle Scholar |
Jungheim, ES, Macones, GA, Odem, RR, Patterson, BW, Lanzendorf, SE, Ratts, VS, and Moley, KH (2011). Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertility and Sterility 95, 1970–1974.
| Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.Crossref | GoogleScholarGoogle Scholar |
Katari, S, Turan, N, Bibikova, M, Erinle, O, Chalian, R, Foster, M, Gaughan, JP, Coutifaris, C, and Sapienza, C (2009). DNA methylation and gene expression differences in children conceived in vitro or in vivo. Human Molecular Genetics 18, 3769–3778.
| DNA methylation and gene expression differences in children conceived in vitro or in vivo.Crossref | GoogleScholarGoogle Scholar |
Kaufman, RJ (1999). Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes & Development 13, 1211–1233.
| Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.Crossref | GoogleScholarGoogle Scholar |
Keller, S, Ridinger, J, Rupp, A-K, Janssen, JWG, and Altevogt, P (2011). Body fluid derived exosomes as a novel template for clinical diagnostics. Journal of Translational Medicine 9, 86.
| Body fluid derived exosomes as a novel template for clinical diagnostics.Crossref | GoogleScholarGoogle Scholar |
Kermack, AJ, Wellstead, SJ, Fisk, HL, Cheong, Y, Houghton, FD, Macklon, NS, and Calder, PC (2021). The fatty acid composition of human follicular fluid is altered by a 6-week dietary intervention that includes marine omega-3 fatty acids. Lipids 56, 201–209.
| The fatty acid composition of human follicular fluid is altered by a 6-week dietary intervention that includes marine omega-3 fatty acids.Crossref | GoogleScholarGoogle Scholar |
Kirillova, A, Smitz, JEJ, Sukhikh, GT, and Mazunin, I (2021). The role of mitochondria in oocyte maturation. Cells 10, 2484.
| The role of mitochondria in oocyte maturation.Crossref | GoogleScholarGoogle Scholar |
Koning, AMH, Kuchenbecker, WKH, Groen, H, Hoek, A, Land, JA, Khan, KS, and Mol, BWJ (2010). Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care. Human Reproduction Update 16, 246–254.
| Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care.Crossref | GoogleScholarGoogle Scholar |
Krisher, RL (2013). In vivo and in vitro environmental effects on mammalian oocyte quality. Annual Review of Animal Biosciences 1, 393–417.
| In vivo and in vitro environmental effects on mammalian oocyte quality.Crossref | GoogleScholarGoogle Scholar |
Lane, M, Zander-Fox, DL, Robker, RL, and McPherson, NO (2015). Peri-conception parental obesity, reproductive health, and transgenerational impacts. Trends in Endocrinology & Metabolism 26, 84–90.
| Peri-conception parental obesity, reproductive health, and transgenerational impacts.Crossref | GoogleScholarGoogle Scholar |
Larsson, N-G (2010). Somatic mitochondrial DNA mutations in mammalian aging. Annual Review of Biochemistry 79, 683–706.
| Somatic mitochondrial DNA mutations in mammalian aging.Crossref | GoogleScholarGoogle Scholar |
Lassi, ZS, Dean, SV, Mallick, D, and Bhutta, ZA (2014). Preconception care: delivery strategies and packages for care. Reproductive Health 11, S7.
| Preconception care: delivery strategies and packages for care.Crossref | GoogleScholarGoogle Scholar |
Leary, C, Leese, HJ, and Sturmey, RG (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction 30, 122–132.
| Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.Crossref | GoogleScholarGoogle Scholar |
LeBlanc S (2010a) Does higher production imply worse reproduction? In ‘28th Annual Western Canadian Dairy Seminar (WCDS), Red Deer, Canada’. (Ed. L Doepel) pp. 253–263. (University of Alberta: Canada)
LeBlanc, S (2010b). Monitoring metabolic health of dairy cattle in the transition period. Journal of Reproduction and Development 56, S29–S35.
| Monitoring metabolic health of dairy cattle in the transition period.Crossref | GoogleScholarGoogle Scholar |
Legro, RS (2016). Mr. Fertility Authority, tear down that weight wall!. Human Reproduction 31, 2662–2664.
| Mr. Fertility Authority, tear down that weight wall!.Crossref | GoogleScholarGoogle Scholar |
Legro, RS (2017). Effects of obesity treatment on female reproduction: results do not match expectations. Fertility and Sterility 107, 860–867.
| Effects of obesity treatment on female reproduction: results do not match expectations.Crossref | GoogleScholarGoogle Scholar |
Leroy, JLMR, Vanholder, T, Delanghe, JR, Opsomer, G, Van Soom, A, Bols, PEJ, Dewulf, J, and de Kruif, A (2004). Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early post partum. Theriogenology 62, 1131–1143.
| Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early post partum.Crossref | GoogleScholarGoogle Scholar |
Leroy, JLMR, Vanholder, T, Mateusen, B, Christophe, A, Opsomer, G, de Kruif, A, Genicot, G, and Van Soom, A (2005). Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. Reproduction 130, 485–495.
| Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro.Crossref | GoogleScholarGoogle Scholar |
Leroy, JLMR, Van Soom, A, Opsomer, G, Goovaerts, IGF, and Bols, PEJ (2008a). Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part II. Mechanisms linking nutrition and reduced oocyte and embryo quality in high-yielding dairy cows. Reproduction in Domestic Animals 43, 623–632.
| Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part II. Mechanisms linking nutrition and reduced oocyte and embryo quality in high-yielding dairy cows.Crossref | GoogleScholarGoogle Scholar |
Leroy, JLMR, Opsomer, G, Van Soom, A, Goovaerts, IGF, and Bols, PEJ (2008b). Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part I. The importance of negative energy balance and altered corpus luteum function to the reduction of oocyte and embryo quality in high-yielding dairy cows. Reproduction in Domestic Animals 43, 612–622.
| Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part I. The importance of negative energy balance and altered corpus luteum function to the reduction of oocyte and embryo quality in high-yielding dairy cows.Crossref | GoogleScholarGoogle Scholar |
Leroy, JLMR, Sturmey, RG, Van Hoeck, V, De Bie, J, McKeegan, PJ, and Bols, PEJ (2014). Dietary fat supplementation and the consequences for oocyte and embryo quality: hype or significant benefit for dairy cow reproduction? Reproduction in Domestic Animals 49, 353–361.
| Dietary fat supplementation and the consequences for oocyte and embryo quality: hype or significant benefit for dairy cow reproduction?Crossref | GoogleScholarGoogle Scholar |
Leroy, JLMR, Valckx, SDM, Jordaens, L, De Bie, J, Desmet, KLJ, Van Hoeck, V, Britt, JH, Marei, WF, and Bols, PEJ (2015). Nutrition and maternal metabolic health in relation to oocyte and embryo quality: critical views on what we learned from the dairy cow model. Reproduction, Fertility and Development 27, 693–703.
| Nutrition and maternal metabolic health in relation to oocyte and embryo quality: critical views on what we learned from the dairy cow model.Crossref | GoogleScholarGoogle Scholar |
Lim, GE, Piske, M, and Johnson, JD (2013). 14-3-3 proteins are essential signalling hubs for beta cell survival. Diabetologia 56, 825–837.
| 14-3-3 proteins are essential signalling hubs for beta cell survival.Crossref | GoogleScholarGoogle Scholar |
Lima A, Burgstaller J, Sanchez-Nieto JM, Rodríguez TA (2018) The mitochondria and the regulation of cell fitness during early mammalian development. In ‘Current topics in developmental biology. Vol. 128’. (Eds B Plusa, AK Hadjantonakis) pp. 339–363. (Academic Press)
Lotthammer, KH (1979). Influence of beta-carotene administration on bovine ovarian-function. Reproduction in Domestic Animals 14, 131–132.
Luke, B, Brown, MB, Stern, JE, Missmer, SA, Fujimoto, VY, Leach, R, A SART Writing Group (2011). Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Human Reproduction 26, 245–252.
| Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates.Crossref | GoogleScholarGoogle Scholar |
Luzzo, KM, Wang, Q, Purcell, SH, Chi, M, Jimenez, PT, Grindler, N, Schedl, T, and Moley, KH (2012). High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. PLoS ONE 7, e49217.
| High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects.Crossref | GoogleScholarGoogle Scholar |
Ma, J-Y, Li, S, Chen, L-N, Schatten, H, Ou, X-H, and Sun, Q-Y (2020). Why is oocyte aneuploidy increased with maternal aging? Journal of Genetics and Genomics 47, 659–671.
| Why is oocyte aneuploidy increased with maternal aging?Crossref | GoogleScholarGoogle Scholar |
Maher, ER, Brueton, LA, Bowdin, SC, Luharia, A, Cooper, W, Cole, TR, Macdonald, F, Sampson, JR, Barratt, CL, Reik, W, and Hawkins, MM (2003). Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). Journal of Medical Genetics 40, 62–64.
| Beckwith-Wiedemann syndrome and assisted reproduction technology (ART).Crossref | GoogleScholarGoogle Scholar |
Marchais, M, Gilbert, I, Bastien, A, Macaulay, A, and Robert, C (2022). Mammalian cumulus-oocyte complex communication: a dialog through long and short distance messaging. Journal of Assisted Reproduction and Genetics 39, 1011–1025.
| Mammalian cumulus-oocyte complex communication: a dialog through long and short distance messaging.Crossref | GoogleScholarGoogle Scholar |
Marei WFA, Leroy JLMR (2021) Cellular stress responses in oocytes: molecular changes and clinical implications. In ‘Cell Biology and Translational Medicine, Volume 16. Advances in Experimental Medicine and Biology’. (Ed. K Turksen) pp. 1–19. (Springer International Publishing: Cham)
Marei, WFA, De Bie, J, Mohey-Elsaeed, O, Wydooghe, E, Bols, PEJ, and Leroy, JLMR (2017). Alpha-linolenic acid protects the developmental capacity of bovine cumulus–oocyte complexes matured under lipotoxic conditions in vitro. Biology of Reproduction 96, 1181–1196.
| Alpha-linolenic acid protects the developmental capacity of bovine cumulus–oocyte complexes matured under lipotoxic conditions in vitro.Crossref | GoogleScholarGoogle Scholar |
Marei, WFA, Van den Bosch, L, Pintelon, I, Mohey-Elsaeed, O, Bols, PEJ, and Leroy, JLMR (2019a). Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model. Human Reproduction 34, 1984–1998.
| Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model.Crossref | GoogleScholarGoogle Scholar |
Marei, WFA, Van Raemdonck, G, Baggerman, G, Bols, PEJ, and Leroy, JLMR (2019b). Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells. Scientific Reports 9, 3673.
| Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells.Crossref | GoogleScholarGoogle Scholar |
Marei, WFA, Van den Bosch, L, Bols, PEJ, and Leroy, JLMR (2019c). Protective effects of mitoquinone during in vitro maturation of bovine oocytes under lipotoxic conditions. Animal Reproduction 16, 737.
Marei, WFA, Smits, A, Mohey-Elsaeed, O, Pintelon, I, Ginneberge, D, Bols, PEJ, Moerloose, K, and Leroy, JLMR (2020). Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice. Scientific Reports 10, 9806.
| Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice.Crossref | GoogleScholarGoogle Scholar |
Marei, WFA, De Bie, J, Xhonneux, I, Andries, S, Britt, JH, and Leroy, JLMR (2022). Metabolic and antioxidant status during transition is associated with changes in the granulosa cell transcriptome in the preovulatory follicle in high-producing dairy cows at the time of breeding. Journal of Dairy Science 105, 6956–6972.
| Metabolic and antioxidant status during transition is associated with changes in the granulosa cell transcriptome in the preovulatory follicle in high-producing dairy cows at the time of breeding.Crossref | GoogleScholarGoogle Scholar |
Marques, A, Santos, P, Antunes, G, Chaveiro, A, and Moreira da Silva, F (2008). Effect of α-tocopherol on in vitro maturation of bovine cumulus-oocyte complexes. Canadian Journal of Animal Science 88, 463–467.
| Effect of α-tocopherol on in vitro maturation of bovine cumulus-oocyte complexes.Crossref | GoogleScholarGoogle Scholar |
Marshall, H, Morrison, A, Studer, M, Pöpperl, H, and Krumlauf, R (1996). Retinoids and Hox genes. The FASEB Journal 10, 969–978.
| Retinoids and Hox genes.Crossref | GoogleScholarGoogle Scholar |
Mary, AEP, Artavia Mora, JI, Ronda Borzone, PA, Richards, SE, and Kies, AK (2021). Vitamin E and beta-carotene status of dairy cows: a survey of plasma levels and supplementation practices. Animal 15, 100303.
| Vitamin E and beta-carotene status of dairy cows: a survey of plasma levels and supplementation practices.Crossref | GoogleScholarGoogle Scholar |
Matoba, S, O’Hara, L, Carter, F, Kelly, AK, Fair, T, Rizos, D, and Lonergan, P (2012). The association between metabolic parameters and oocyte quality early and late postpartum in Holstein dairy cows. Journal of Dairy Science 95, 1257–1266.
| The association between metabolic parameters and oocyte quality early and late postpartum in Holstein dairy cows.Crossref | GoogleScholarGoogle Scholar |
Mermillod, P, Dalbies-Tran, R, Uzbekova, S, Thélie, A, Traverso, J-M, Perreau, C, Papillier, P, and Monget, P (2008). Factors affecting oocyte quality: who is driving the follicle? Reproduction in Domestic Animals 43, 393–400.
| Factors affecting oocyte quality: who is driving the follicle?Crossref | GoogleScholarGoogle Scholar |
Metwally, M, Li, TC, and Ledger, WL (2007). The impact of obesity on female reproductive function. Obesity Reviews 8, 515–523.
| The impact of obesity on female reproductive function.Crossref | GoogleScholarGoogle Scholar |
Meyer, H, Ahlswede, L, and Lotthammer, KH (1975). A specific, vitamin A independent effect of beta carotene on cattle fertility. 1. Experimental arrangement, body development and ovarian function. Deutsche tierärztliche Wochenschrift 82, 444–449.
Milagros Rocha, M, and Victor, VM (2007). Targeting antioxidants to mitochondria and cardiovascular diseases: the effects of mitoquinone. Medical Science Monitor 13, RA132–RA145.
Miller, JK, Brzezinska-Slebodzinska, E, and Madsen, FC (1993). Oxidative stress, antioxidants, and animal function. Journal of Dairy Science 76, 2812–2823.
| Oxidative stress, antioxidants, and animal function.Crossref | GoogleScholarGoogle Scholar |
Mirabi, P, Chaichi, MJ, Esmaeilzadeh, S, Ali Jorsaraei, SG, Bijani, A, Ehsani, M, and Hashemi Karooee, SF (2017). The role of fatty acids on ICSI outcomes: a prospective cohort study. Lipids in Health and Disease 16, 18.
| The role of fatty acids on ICSI outcomes: a prospective cohort study.Crossref | GoogleScholarGoogle Scholar |
Moghadam, ARE, Moghadam, MT, Hemadi, M, and Saki, G (2022). Oocyte quality and aging. JBRA Assisted Reproduction 26, 105–122.
| Oocyte quality and aging.Crossref | GoogleScholarGoogle Scholar |
Moholdt, T, and Hawley, JA (2020). Maternal lifestyle interventions: targeting preconception health. Trends in Endocrinology & Metabolism 31, 561–569.
| Maternal lifestyle interventions: targeting preconception health.Crossref | GoogleScholarGoogle Scholar |
Mondou, E, Dufort, I, Gohin, M, Fournier, E, and Sirard, M-A (2012). Analysis of microRNAs and their precursors in bovine early embryonic development. Molecular Human Reproduction 18, 425–434.
| Analysis of microRNAs and their precursors in bovine early embryonic development.Crossref | GoogleScholarGoogle Scholar |
Moore, SG, O’Gorman, A, Brennan, L, Fair, T, and Butler, ST (2017). Follicular fluid and serum metabolites in Holstein cows are predictive of genetic merit for fertility. Reproduction, Fertility and Development 29, 658–669.
| Follicular fluid and serum metabolites in Holstein cows are predictive of genetic merit for fertility.Crossref | GoogleScholarGoogle Scholar |
Münch, C, and Harper, JW (2016). Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation. Nature 534, 710–713.
| Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation.Crossref | GoogleScholarGoogle Scholar |
Mutsaerts, MAQ, van Oers, AM, Groen, H, Burggraaff, JM, Kuchenbecker, WKH, Perquin, DAM, Koks, CAM, van Golde, R, Kaaijk, EM, Schierbeek, JM, Oosterhuis, GJE, Broekmans, FJ, Bemelmans, WJE, Lambalk, CB, Verberg, MFG, van der Veen, F, Klijn, NF, Mercelina, PEAM, van Kasteren, YM, Nap, AW, Brinkhuis, EA, Vogel, NEA, Mulder, RJAB, Gondrie, ETCM, de Bruin, JP, Sikkema, JM, de Greef, MHG, ter Bogt, NCW, Land, JA, Mol, BWJ, and Hoek, A (2016). Randomized trial of a lifestyle program in obese infertile women. The New England Journal of Medicine 374, 1942–1953.
| Randomized trial of a lifestyle program in obese infertile women.Crossref | GoogleScholarGoogle Scholar |
Nakagawa, S, and FitzHarris, G (2017). Intrinsically defective microtubule dynamics contribute to age-related chromosome segregation errors in mouse oocyte meiosis-I. Current Biology 27, 1040–1047.
| Intrinsically defective microtubule dynamics contribute to age-related chromosome segregation errors in mouse oocyte meiosis-I.Crossref | GoogleScholarGoogle Scholar |
Nasiri, N, Moini, A, Eftekhari-Yazdi, P, Karimian, L, Salman-Yazdi, R, Zolfaghari, Z, and Arabipoor, A (2015). Abdominal obesity can induce both systemic and follicular fluid oxidative stress independent from polycystic ovary syndrome. European Journal of Obstetrics & Gynecology and Reproductive Biology 184, 112–116.
| Abdominal obesity can induce both systemic and follicular fluid oxidative stress independent from polycystic ovary syndrome.Crossref | GoogleScholarGoogle Scholar |
Natarajan, R, Shankar, MB, and Munuswamy, D (2010). Effect of α-tocopherol supplementation on in vitro maturation of sheep oocytes and in vitro development of preimplantation sheep embryos to the blastocyst stage. Journal of Assisted Reproduction and Genetics 27, 483–490.
| Effect of α-tocopherol supplementation on in vitro maturation of sheep oocytes and in vitro development of preimplantation sheep embryos to the blastocyst stage.Crossref | GoogleScholarGoogle Scholar |
Nishihara, T, Matsumoto, K, Hosoi, Y, and Morimoto, Y (2018). Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome. Reproductive Medicine and Biology 17, 481–486.
| Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome.Crossref | GoogleScholarGoogle Scholar |
O’Doherty, AM, O’Gorman, A, al Naib, A, Brennan, L, Daly, E, Duffy, P, and Fair, T (2014). Negative energy balance affects imprint stability in oocytes recovered from postpartum dairy cows. Genomics 104, 177–185.
| Negative energy balance affects imprint stability in oocytes recovered from postpartum dairy cows.Crossref | GoogleScholarGoogle Scholar |
Paes, VM, Vieira, LA, Correia, HHV, Sa, NAR, Moura, AAA, Sales, AD, Rodrigues, APR, Magalhães-Padilha, DM, Santos, FW, Apgar, GA, Campello, CC, Camargo, LSA, and Figueiredo, JR (2016). Effect of heat stress on the survival and development of in vitro cultured bovine preantral follicles and on in vitro maturation of cumulus–oocyte complex. Theriogenology 86, 994–1003.
| Effect of heat stress on the survival and development of in vitro cultured bovine preantral follicles and on in vitro maturation of cumulus–oocyte complex.Crossref | GoogleScholarGoogle Scholar |
Pan, Z, Zhang, J, Li, Q, Li, Y, Shi, F, Xie, Z, and Liu, H (2012). Current advances in epigenetic modification and alteration during mammalian ovarian folliculogenesis. Journal of Genetics and Genomics 39, 111–123.
| Current advances in epigenetic modification and alteration during mammalian ovarian folliculogenesis.Crossref | GoogleScholarGoogle Scholar |
Pandey, S, Pandey, S, Maheshwari, A, and Bhattacharya, S (2010). The impact of female obesity on the outcome of fertility treatment. Journal of Human Reproductive Sciences 3, 62–67.
| The impact of female obesity on the outcome of fertility treatment.Crossref | GoogleScholarGoogle Scholar |
Parr, MH, Crowe, MA, Lonergan, P, Evans, ACO, Fair, T, and Diskin, MG (2015). The concurrent and carry over effects of long term changes in energy intake before insemination on pregnancy per artificial insemination in heifers. Animal Reproduction Science 157, 87–94.
| The concurrent and carry over effects of long term changes in energy intake before insemination on pregnancy per artificial insemination in heifers.Crossref | GoogleScholarGoogle Scholar |
Pasquali, R (2006). Obesity, fat distribution and infertility. Maturitas 54, 363–371.
| Obesity, fat distribution and infertility.Crossref | GoogleScholarGoogle Scholar |
Pennington, KA, van der Walt, N, Pollock, KE, Talton, OO, and Schulz, LC (2017). Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice. Biology of Reproduction 96, 435–445.
| Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice.Crossref | GoogleScholarGoogle Scholar |
Peral-Sanchez, I, Hojeij, B, Ojeda, DA, Steegers-Theunissen, RPM, and Willaime-Morawek, S (2022). Epigenetics in the uterine environment: how maternal diet and ART may influence the epigenome in the offspring with long-term health consequences. Genes 13, 31.
| Epigenetics in the uterine environment: how maternal diet and ART may influence the epigenome in the offspring with long-term health consequences.Crossref | GoogleScholarGoogle Scholar |
Piersanti, RL, Horlock, AD, Block, J, Santos, JEP, Sheldon, IM, and Bromfield, JJ (2019). Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease. Reproduction 158, 35–46.
| Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease.Crossref | GoogleScholarGoogle Scholar |
Piersanti, RL, Block, J, Ma, Z, Jeong, KC, Santos, JEP, Yu, F, Sheldon, IM, and Bromfield, JJ (2020). Uterine infusion of bacteria alters the transcriptome of bovine oocytes. FASEB BioAdvances 2, 506–520.
| Uterine infusion of bacteria alters the transcriptome of bovine oocytes.Crossref | GoogleScholarGoogle Scholar |
Pontes, GCS, Monteiro, PLJ, Prata, AB, Guardieiro, MM, Pinto, DAM, Fernandes, GO, Wiltbank, MC, Santos, JEP, and Sartori, R (2015). Effect of injectable vitamin E on incidence of retained fetal membranes and reproductive performance of dairy cows. Journal of Dairy Science 98, 2437–2449.
| Effect of injectable vitamin E on incidence of retained fetal membranes and reproductive performance of dairy cows.Crossref | GoogleScholarGoogle Scholar |
Practice Committee of the American Society for Reproductive Medicine (2015). Obesity and reproduction: a committee opinion. Fertility and Sterilility 104, 1116–1126.
| Obesity and reproduction: a committee opinion.Crossref | GoogleScholarGoogle Scholar |
Raposo, G, and Stoorvogel, W (2013). Extracellular vesicles: exosomes, microvesicles, and friends. Journal of Cell Biology 200, 373–383.
| Extracellular vesicles: exosomes, microvesicles, and friends.Crossref | GoogleScholarGoogle Scholar |
Reynolds, KA, Boudoures, AL, Chi, MM-Y, Wang, Q, and Moley, KH (2015). Adverse effects of obesity and/or high-fat diet on oocyte quality and metabolism are not reversible with resumption of regular diet in mice. Reproduction, Fertility and Development 27, 716–724.
| Adverse effects of obesity and/or high-fat diet on oocyte quality and metabolism are not reversible with resumption of regular diet in mice.Crossref | GoogleScholarGoogle Scholar |
Rizos, D, Burke, L, Duffy, P, Wade, M, Mee, JF, O’Farrell, KJ, MacSiurtain, M, Boland, MP, and Lonergan, P (2005). Comparisons between nulliparous heifers and cows as oocyte donors for embryo production in vitro. Theriogenology 63, 939–949.
| Comparisons between nulliparous heifers and cows as oocyte donors for embryo production in vitro.Crossref | GoogleScholarGoogle Scholar |
Roseboom, T, de Rooij, S, and Painter, R (2006). The Dutch famine and its long-term consequences for adult health. Early Human Development 82, 485–491.
| The Dutch famine and its long-term consequences for adult health.Crossref | GoogleScholarGoogle Scholar |
Roth, Z (2008). Heat stress, the follicle, and its enclosed oocyte: mechanisms and potential strategies to improve fertility in dairy cows. Reproduction in Domestic Animals 43, 238–244.
| Heat stress, the follicle, and its enclosed oocyte: mechanisms and potential strategies to improve fertility in dairy cows.Crossref | GoogleScholarGoogle Scholar |
Roth, Z (2017). Effect of heat stress on reproduction in dairy cows: insights into the cellular and molecular responses of the oocyte. Annual Review of Animal Biosciences 5, 151–170.
| Effect of heat stress on reproduction in dairy cows: insights into the cellular and molecular responses of the oocyte.Crossref | GoogleScholarGoogle Scholar |
Roth, Z (2018). Symposium review: Reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function. Journal of Dairy Science 101, 3642–3654.
| Symposium review: Reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function.Crossref | GoogleScholarGoogle Scholar |
Roth, Z, Meidan, R, Braw-Tal, R, and Wolfenson, D (2000). Immediate and delayed effects of heat stress on follicular development and its association with plasma FSH and inhibin concentration in cows. Journal of Reproduction and Fertility 120, 83–90.
| Immediate and delayed effects of heat stress on follicular development and its association with plasma FSH and inhibin concentration in cows.Crossref | GoogleScholarGoogle Scholar |
Ruebel, M, Shankar, K, Gaddy, D, Lindsey, F, Badger, T, and Andres, A (2016). Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1. American Journal of Physiology-Endocrinology and Metabolism 311, E269–E277.
| Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1.Crossref | GoogleScholarGoogle Scholar |
Runkel, ED, Baumeister, R, and Schulze, E (2014). Mitochondrial stress: balancing friend and foe. Experimental Gerontology 56, 194–201.
| Mitochondrial stress: balancing friend and foe.Crossref | GoogleScholarGoogle Scholar |
Rutkowski, DT, and Kaufman, RJ (2004). A trip to the ER: coping with stress. Trends in Cell Biology 14, 20–28.
| A trip to the ER: coping with stress.Crossref | GoogleScholarGoogle Scholar |
Saben, JL, Boudoures, AL, Asghar, Z, Thompson, A, Drury, A, Zhang, W, Chi, M, Cusumano, A, Scheaffer, S, and Moley, KH (2016). Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Reports 16, 1–8.
| Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations.Crossref | GoogleScholarGoogle Scholar |
Santonocito, M, Vento, M, Guglielmino, MR, Battaglia, R, Wahlgren, J, Ragusa, M, Barbagallo, D, Borzì, P, Rizzari, S, Maugeri, M, Scollo, P, Tatone, C, Valadi, H, Purrello, M, and Di Pietro, C (2014). Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation. Fertility and Sterility 102, 1751–1761.E1.
| Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation.Crossref | GoogleScholarGoogle Scholar |
Santos, TA, El Shourbagy, S, and St. John, JC (2006). Mitochondrial content reflects oocyte variability and fertilization outcome. Fertility and Sterility 85, 584–591.
| Mitochondrial content reflects oocyte variability and fertilization outcome.Crossref | GoogleScholarGoogle Scholar |
Sartori, R, Sartor-Bergfelt, R, Mertens, SA, Guenther, JN, Parrish, JJ, and Wiltbank, MC (2002). Fertilization and early embryonic development in heifers and lactating cows in summer and lactating and dry cows in winter. Journal of Dairy Science 85, 2803–2812.
| Fertilization and early embryonic development in heifers and lactating cows in summer and lactating and dry cows in winter.Crossref | GoogleScholarGoogle Scholar |
Setti, AS, Halpern, G, Braga, DPdAF, Iaconelli, A, and Borges, E (2022). Maternal lifestyle and nutritional habits are associated with oocyte quality and ICSI clinical outcomes. Reproductive BioMedicine Online 44, 370–379.
| Maternal lifestyle and nutritional habits are associated with oocyte quality and ICSI clinical outcomes.Crossref | GoogleScholarGoogle Scholar |
Showell, MG, Mackenzie-Proctor, R, Jordan, V, and Hart, RJ (2020). Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 7, CD007807.
| Antioxidants for female subfertility.Crossref | GoogleScholarGoogle Scholar |
Si, C, Wang, N, Wang, M, Liu, Y, Niu, Z, and Ding, Z (2021). TMT-based proteomic and bioinformatic analyses of human granulosa cells from obese and normal-weight female subjects. Reproductive Biology and Endocrinology 19, 75.
| TMT-based proteomic and bioinformatic analyses of human granulosa cells from obese and normal-weight female subjects.Crossref | GoogleScholarGoogle Scholar |
Sim, KA, Partridge, SR, and Sainsbury, A (2014). Does weight loss in overweight or obese women improve fertility treatment outcomes? A systematic review. Obesity Reviews 15, 839–850.
| Does weight loss in overweight or obese women improve fertility treatment outcomes? A systematic review.Crossref | GoogleScholarGoogle Scholar |
Simon, C (2019). Introduction: preconceptional care: do we have to care? Fertility and Sterility 112, 611–612.
| Introduction: preconceptional care: do we have to care?Crossref | GoogleScholarGoogle Scholar |
Simon, C, Greening, DW, Bolumar, D, Balaguer, N, Salamonsen, LA, and Vilella, F (2018). Extracellular vesicles in human reproduction in health and disease. Endocrine Reviews 39, 292–332.
| Extracellular vesicles in human reproduction in health and disease.Crossref | GoogleScholarGoogle Scholar |
Smallwood, SA, Tomizawa, S-i, Krueger, F, Ruf, N, Carli, N, Segonds-Pichon, A, Sato, S, Hata, K, Andrews, SR, and Kelsey, G (2011). Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nature Genetics 43, 811–814.
| Dynamic CpG island methylation landscape in oocytes and preimplantation embryos.Crossref | GoogleScholarGoogle Scholar |
Smits A (2022) ‘Opportunities for improvement of oocyte quality in metabolically compromised conditions: from fundamental discoveries in the well until the development of preconception care strategies in an obese mouse model.’ (University of Antwerp: Antwerp)
Smits, A, Marei, W, De Ketelaere, M, Meulders, B, Bols, P, and Leroy, J (2020a). 3 Dietary caloric normalization or restriction as preconception care strategies: impact on metabolic health and fertility in high fat-induced obese outbred mice. Reproduction, Fertility and Development 32, 126.
| 3 Dietary caloric normalization or restriction as preconception care strategies: impact on metabolic health and fertility in high fat-induced obese outbred mice.Crossref | GoogleScholarGoogle Scholar |
Smits, A, Leroy, JLMR, Bols, PEJ, De Bie, J, and Marei, WFA (2020b). Rescue potential of supportive embryo culture conditions on bovine embryos derived from metabolically compromised oocytes. International Journal of Molecular Sciences 21, 8206.
| Rescue potential of supportive embryo culture conditions on bovine embryos derived from metabolically compromised oocytes.Crossref | GoogleScholarGoogle Scholar |
Smits, A, Marei, WFA, De Neubourg, D, and Leroy, JLMR (2021). Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice. Reproductive Biology and Endocrinology 19, 166.
| Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice.Crossref | GoogleScholarGoogle Scholar |
Sohel, MMH, Hoelker, M, Noferesti, SS, Salilew-Wondim, D, Tholen, E, Looft, C, Rings, F, Uddin, MJ, Spencer, TE, Schellander, K, and Tesfaye, D (2013). Exosomal and non-exosomal transport of extra-cellular microRNAs in follicular fluid: implications for bovine oocyte developmental competence. PLoS ONE 8, e78505.
| Exosomal and non-exosomal transport of extra-cellular microRNAs in follicular fluid: implications for bovine oocyte developmental competence.Crossref | GoogleScholarGoogle Scholar |
Torres-Júnior, JRdS, Pires, MdFA, de Sá, WF, Ferreira, AdM, Viana, JHM, Camargo, LSA, Ramos, AA, Folhadella, IM, Polisseni, J, de Freitas, C, Clemente, CAA, de Sa Filho, MF, Paula-Lopes, FF, and Baruselli, PS (2008). Effect of maternal heat-stress on follicular growth and oocyte competence in Bos indicus cattle. Theriogenology 69, 155–166.
| Effect of maternal heat-stress on follicular growth and oocyte competence in Bos indicus cattle.Crossref | GoogleScholarGoogle Scholar |
Truong, T, and Gardner, DK (2017). Antioxidants improve IVF outcome and subsequent embryo development in the mouse. Human Reproduction 32, 2404–2413.
| Antioxidants improve IVF outcome and subsequent embryo development in the mouse.Crossref | GoogleScholarGoogle Scholar |
Truong, T, Harvey, AJ, and Gardner, DK (2022). Antioxidant supplementation of mouse embryo culture or vitrification media support more in-vivo-like gene expression post-transfer. Reproductive BioMedicine Online 44, 393–410.
| Antioxidant supplementation of mouse embryo culture or vitrification media support more in-vivo-like gene expression post-transfer.Crossref | GoogleScholarGoogle Scholar |
Tsagareli, V, Noakes, M, and Norman, RJ (2006). Effect of a very-low-calorie diet on in vitro fertilization outcomes. Fertility and Sterility 86, 227–229.
| Effect of a very-low-calorie diet on in vitro fertilization outcomes.Crossref | GoogleScholarGoogle Scholar |
Valadi, H, Ekström, K, Bossios, A, Sjöstrand, M, Lee, JJ, and Lötvall, JO (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature Cell Biology 9, 654–659.
| Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.Crossref | GoogleScholarGoogle Scholar |
Valckx SDM, Leroy JLMR (2015) Chapter 4 - The effect of maternal metabolic health and diet on the follicular fluid composition and potential consequences for oocyte and embryo quality. In ‘Handbook of fertility’. (Ed. RR Watson) pp. 35–44. (Academic Press: San Diego)
Valckx, SDM, De Pauw, I, De Neubourg, D, Inion, I, Berth, M, Fransen, E, Bols, PEJ, and Leroy, JLMR (2012). BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Human Reproduction 27, 3531–3539.
| BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality.Crossref | GoogleScholarGoogle Scholar |
Valckx, SDM, Arias-Alvarez, M, De Pauw, I, Fievez, V, Vlaeminck, B, Fransen, E, Bols, PEJ, and Leroy, JLMR (2014a). Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study. Reproductive Biology and Endocrinology 12, 13.
| Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study.Crossref | GoogleScholarGoogle Scholar |
Valckx, SDM, Van Hoeck, V, Arias-Alvarez, M, Maillo, V, Lopez-Cardona, AP, Gutierrez-Adan, A, Berth, M, Cortvrindt, R, Bols, PEJ, and Leroy, JLMR (2014b). Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence. Fertility and Sterility 102, 1769–1776.E1.
| Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence.Crossref | GoogleScholarGoogle Scholar |
Valeggia, C, and Ellison, PT (2009). Interactions between metabolic and reproductive functions in the resumption of postpartum fecundity. American Journal of Human Biology 21, 559–566.
| Interactions between metabolic and reproductive functions in the resumption of postpartum fecundity.Crossref | GoogleScholarGoogle Scholar |
Van Blerkom, J (2004). Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence. Reproduction 128, 269–280.
| Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence.Crossref | GoogleScholarGoogle Scholar |
Van der Steeg, JW, Steures, P, Eijkemans, MJC, Habbema, JDF, Hompes, PGA, Burggraaff, JM, Oosterhuis, GJE, Bossuyt, PMM, van der Veen, F, and Mol, BWJ (2008). Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Human Reproduction 23, 324–328.
| Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women.Crossref | GoogleScholarGoogle Scholar |
Van Hoeck, V, Sturmey, RG, Bermejo-Alvarez, P, Rizos, D, Gutierrez-Adan, A, Leese, HJ, Bols, PEJ, and Leroy, JLMR (2011). Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. PLoS ONE 6, e23183.
| Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology.Crossref | GoogleScholarGoogle Scholar |
Van Hoeck, V, Leroy, JLMR, Arias Alvarez, M, Rizos, D, Gutierrez-Adan, A, Schnorbusch, K, Bols, PEJ, Leese, HJ, and Sturmey, RG (2013). Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights. Reproduction 145, 33–44.
| Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights.Crossref | GoogleScholarGoogle Scholar |
Van Hoeck, V, Bols, PEJ, Binelli, M, and Leroy, JLMR (2014). Reduced oocyte and embryo quality in response to elevated non-esterified fatty acid concentrations: a possible pathway to subfertility? Animal Reproduction Science 149, 19–29.
| Reduced oocyte and embryo quality in response to elevated non-esterified fatty acid concentrations: a possible pathway to subfertility?Crossref | GoogleScholarGoogle Scholar |
Van Hoeck, V, Rizos, D, Gutierrez-Adan, A, Pintelon, I, Jorssen, E, Dufort, I, Sirard, MA, Verlaet, A, Hermans, N, Bols, PEJ, and Leroy, JLMR (2015). Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations. Reproduction, Fertility and Development 27, 372–384.
| Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations.Crossref | GoogleScholarGoogle Scholar |
Vangoitsenhoven, R, van der Ende, M, Corbeels, K, Monteiro Carvalho Mori Cunha, JP, Lannoo, M, Bedossa, P, van der Merwe, S, Mertens, A, Gesquiere, I, Meulemans, A, Matthys, C, Mathieu, C, Overbergh, L, and Van der Schueren, B (2018). At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice. PLoS One 13, e0200779.
| At similar weight loss, dietary composition determines the degree of glycemic improvement in diet-induced obese C57BL/6 mice.Crossref | GoogleScholarGoogle Scholar |
von Soosten, D, Meyer, U, Flachowsky, G, and Dänicke, S (2020). Dairy cow health and greenhouse gas emission intensity. Dairy 1, 3–29.
| Dairy cow health and greenhouse gas emission intensity.Crossref | GoogleScholarGoogle Scholar |
Wang, Z, Guo, W, Kuang, X, Hou, S, and Liu, H (2017). Nanopreparations for mitochondria targeting drug delivery system: current strategies and future prospective. Asian Journal of Pharmaceutical Sciences 12, 498–508.
| Nanopreparations for mitochondria targeting drug delivery system: current strategies and future prospective.Crossref | GoogleScholarGoogle Scholar |
Waterland, RA, Kellermayer, R, Laritsky, E, Rayco-Solon, P, Harris, RA, Travisano, M, Zhang, W, Torskaya, MS, Zhang, J, Shen, L, Manary, MJ, and Prentice, AM (2010). Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genetics 6, e1001252.
| Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles.Crossref | GoogleScholarGoogle Scholar |
Watson, AJ (2007). Oocyte cytoplasmic maturation: a key mediator of oocyte and embryo developmental competence. Journal of Animal Science 85, E1–E3.
| Oocyte cytoplasmic maturation: a key mediator of oocyte and embryo developmental competence.Crossref | GoogleScholarGoogle Scholar |
WHO and UNFPA (2006) Low-fertility - the future of Europe? In ‘Entre Nous. Vol. 63’. (WHO)
WHO Regional Office for Europe (2022) Who European regional obesity report 2022. WHO Regional Office for Europe, Copenhagen.
Wu, LL-Y, Dunning, KR, Yang, X, Russell, DL, Lane, M, Norman, RJ, and Robker, RL (2010). High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates. Endocrinology 151, 5438–5445.
| High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates.Crossref | GoogleScholarGoogle Scholar |
Wu, LL-Y, Norman, RJ, and Robker, RL (2011). The impact of obesity on oocytes: evidence for lipotoxicity mechanisms. Reproduction, Fertility and Development 24, 29–34.
| The impact of obesity on oocytes: evidence for lipotoxicity mechanisms.Crossref | GoogleScholarGoogle Scholar |
Wyse, BA, Fuchs Weizman, N, Defer, M, Montbriand, J, Szaraz, P, and Librach, C (2021). The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes. Reproductive BioMedicine Online 43, 738–746.
| The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes.Crossref | GoogleScholarGoogle Scholar |
Yang, X, Wu, LL, Chura, LR, Liang, X, Lane, M, Norman, RJ, and Robker, RL (2012). Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes. Fertility and Sterility 97, 1438–1443.
| Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes.Crossref | GoogleScholarGoogle Scholar |
Yin, C, Liu, J, He, B, Jia, L, Gong, Y, Guo, H, and Zhao, R (2019). Heat stress induces distinct responses in porcine cumulus cells and oocytes associated with disrupted gap junction and trans-zonal projection colocalization. Journal of Cellular Physiology 234, 4787–4798.
| Heat stress induces distinct responses in porcine cumulus cells and oocytes associated with disrupted gap junction and trans-zonal projection colocalization.Crossref | GoogleScholarGoogle Scholar |
Young, LE, Fernandes, K, McEvoy, TG, Butterwith, SC, Gutierrez, CG, Carolan, C, Broadbent, PJ, Robinson, JJ, Wilmut, I, and Sinclair, KD (2001). Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nature Genetics 27, 153–154.
| Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.Crossref | GoogleScholarGoogle Scholar |
Yu C, Zhou J-J, Fan H-Y (2016) Studying the functions of TGF-β signaling in the ovary. In ‘TGF-β signaling: methods and protocols’. (Eds X-H Feng, P Xu, X Lin) pp. 301–311. (Springer New York: New York, NY)
Zarbakhsh, S (2021). Effect of antioxidants on preimplantation embryo development in vitro: a review. Zygote 29, 179–193.
| Effect of antioxidants on preimplantation embryo development in vitro: a review.Crossref | GoogleScholarGoogle Scholar |
Zhang, K, and Kaufman, RJ (2008). From endoplasmic-reticulum stress to the inflammatory response. Nature 454, 455–462.
| From endoplasmic-reticulum stress to the inflammatory response.Crossref | GoogleScholarGoogle Scholar |
