Relationship between mitochondrial DNA haplogroup and litter size in the pig
Dan Wang A B , Chao Ning A B , Jian-Feng Liu A and Xingbo Zhao
A C
+ Author Affiliations
- Author Affiliations
A College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
B College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271000, China.
C Corresponding author. Email: zhxb@cau.edu.cn
Reproduction, Fertility and Development 32(3) 267-273 https://doi.org/10.1071/RD19035
Submitted: 18 January 2019 Accepted: 18 June 2019 Published: 3 October 2019
Abstract
Mitochondrial DNA (mtDNA) has been widely associated with complex traits in farm animals. The present study evaluated the effects of mtDNA on litter size in pigs. Mitogenome sequencing of 1017 sows distinguished 232 variations, including 229 single nucleotide polymorphisms and three indels, which constituted 11 haplotypes and further clustered into two haplogroups that differed significantly (P < 0.05) in litter size. In order to explain the associations between the effect of haplogroup on litter size and different maternal origins, extant mitogenome sequences were used for phylogenetic or principal component analyses. The results of these analyses led to the identification of two groups, representing Chinese and European origins. The haplotypes corresponding to high litter size were all in the Chinese cluster, whereas haplotypes corresponding to low litter size were all in the European cluster. The results of this study suggest that the effect of haplogroup on litter size in the pig could be caused by diverse maternal origins, and that mtDNA haplogroup may be a marker for genetic selection for pig litter size.
Additional keywords: association analysis, haplotype, haplogroup, mitogenome.
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