Contraceptive efficacy and dose-response effects of the gonadotrophin-releasing hormone (GnRH) agonist deslorelin in Tasmanian devils (Sarcophilus harrisii)
Holly R. Cope
A , Sarah Peck B , Rebecca Hobbs C , Tamara Keeley D , Stephen Izzard B , Wei Yeen-Yap E , Peter J. White F , Carolyn J. Hogg A G and Catherine A. Herbert A H
+ Author Affiliations
- Author Affiliations
A School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, J.D. Stewart Building B01, Camperdown, NSW 2006, Australia.
B Wildlife Management Branch, Department of Primary Industries, Parks, Water and Environment, Hobart, Tas. 7000, Australia.
C Taronga Institute of Science and Learning, Taronga Conservation Society, NSW 2088, Australia.
D School of Agriculture and Food Sciences, Faculty of Science, The University of Queensland, Gatton, Qld 4343, Australia.
E Hobart, Tas. 7000, Australia.
F Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, R.M.C. Gunn Building B19, Camperdown, NSW 2006, Australia.
G Zoo and Aquarium Association Australasia, Mosman, NSW 2088, Australia.
H Corresponding author. Email: catherine.herbert@sydney.edu.au
Reproduction, Fertility and Development 31(9) 1473-1485 https://doi.org/10.1071/RD18407
Submitted: 8 October 2018 Accepted: 13 March 2019 Published: 3 May 2019
Abstract
Contraception is increasingly used to manage breeding opportunities in conservation-dependent species. This study aimed to determine the efficacy, duration of effect, optimal dose and potential side effects of Suprelorin contraceptive implants in Tasmanian devils, for use in the conservation breeding program. In our pilot study, Suprelorin was found to effectively suppress oestrous cycles in female devils, yet caused a paradoxical increase in testosterone in males. Therefore, we focussed on females in further trials. Females received one (n = 5), two (n = 5) or no (n = 5) Suprelorin implants, with quarterly gonadotrophin-releasing hormone (GnRH) challenges used to test pituitary responsiveness over two breeding seasons. Both Suprelorin doses suppressed pituitary responsiveness for at least one breeding season, with a reduced effect in the second. There was a dose-response effect on duration rather than magnitude of effect, with high-dose devils remaining suppressed for longer than low-dose animals. There were no apparent negative effects on general health, yet captivity and contraception together may cause weight gain. Suprelorin contraceptive implants are now routinely used in the Save the Tasmanian Devil Program insurance metapopulation to meet the aims of maintaining genetic and behavioural integrity by controlling individual reproductive contributions in group housing situations.
Additional keywords: captive breeding, DFTD, fertility control, marsupial, Suprelorin, wildlife.
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