Paternal exposure to bupropion affects postnatal development in the offspring
E. S. A. M. Sanches A B , F. Tsuzuki A , F. Joinhas A , G. B. Figueiras D , E. G. Moreira C and M. J. S. Salles A E
+ Author Affiliations
- Author Affiliations
A Department of Biology, Universidade Estadual de Londrina, PR 445 Km 380, 86057-970, Londrina, Parana, Brazil.
B Department of General Pathology, Universidade Estadual de Londrina, PR 445 Km 380, 86057-970, Londrina, Parana, Brazil.
C Department of Physiological Sciences, Universidade Estadual de Londrina, PR 445 Km 380, 86057-970, Londrina, Parana, Brazil.
D Department of General Psychology and Behavioral Analysis, Universidade Estadual de Londrina, PR 445 Km 380, 86057-970, Londrina, Parana, Brazil.
E Corresponding author. Email: salmjs00@gmail.com
Reproduction, Fertility and Development 31(10) 1539-1544 https://doi.org/10.1071/RD18403
Submitted: 5 October 2018 Accepted: 2 May 2019 Published: 4 July 2019
Abstract
The aim of this study was to evaluate whether paternal exposure to bupropion hydrochloride (BUP), an inhibitor of dopamine and noradrenaline reuptake, would affect the postnatal development of offspring. Male mice were divided into a BUP-treated (40 mg kg−1 day−1 by gavage, 45 days) or control (saline by gavage, 45 days) group (n = 20 in each group). From Day 35 to Day 45 of treatment, males were allowed to mate with drug-naïve female mice. Postnatal development of the offspring (both sexes) was evaluated from Postnatal day (PND) 1 to PND60. Physical development parameters (weight gain, body length, incisor eruption, pinna detachment), anogenital distance, vaginal opening, reflexes (palmar grasp, surface righting, negative geotaxis and adult gait) and some behavioural parameters (locomotor activity and anxiety-like behaviour) were altered in the offspring of BUP-treated males. The results demonstrate that paternal exposure to BUP induces long-lasting changes in the postnatal development of the offspring.
Additional keywords: open-field, physical development, reflex ontology.
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