Proteomic analysis of the endometrium during early pregnancy in the domestic pig
Justyna Kolakowska A , Serhiy Souchelnytskyi B C D , Ravi Kanth Rao Saini B E F and Anita Franczak A G
+ Author Affiliations
- Author Affiliations
A Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland.
B Neurocentrum, Karolinska University Hospital, Neurologmottagningen, 171 76, Solna, Stockholm, Sweden.
C Oranta Cancer Diagnostics AB, Norrens väg 73, 752 63, Uppsala, Sweden.
D College of Medicine, Qatar University, Building H12, PO Box 2713, Doha, Qatar.
E Sahlgrenska Cancer Center, University of Gothenburg, Medicinaregatan 1F, Box 425, 405 30, Gothenburg, Sweden.
F The Scripps Research Institute, 10550 North Torrey Pines Road, MB27, La Jolla, CA 92037, USA.
G Corresponding author. Email: anitaf@uwm.edu.pl
Reproduction, Fertility and Development 29(11) 2255-2268 https://doi.org/10.1071/RD16435
Submitted: 31 October 2016 Accepted: 21 February 2017 Published: 18 April 2017
Abstract
Reproductive processes in domestic pigs have been studied extensively. Pigs are one of the main sources of meat for human consumption and are an established model for investigations into mammalian, including human, reproductive physiology. Studies of the uterus during early pregnancy will lead to a better understanding of mechanisms governing pregnancy. Proteomics provides the possibility to explore endometrial functions in an unbiased way. The aim of the study was to compare endometrium harvested from Days 12–13 and 15–16 of pregnancy with the corresponding days of the oestrous cycle. We identified endometrial proteins that are unique to the early stages of pregnancy (Days 12–13 and 15–16). Twenty-one proteins were identified that were uniquely expressed on the selected days of pregnancy or the oestrous cycle. Out of 21 identified proteins, 14 referred to the pregnancy periods. Systemic analysis of the identified proteins revealed cell adhesion and cytoskeletal organisation as two of the major functions, both of which are important for the establishment and maintenance of pregnancy. Thrombospondin 1 expression was validated using western blotting analysis and the results suggest its involvement in the adhesiveness of the embryo during the peri-implantation period in pigs.
Additional keywords: implantation, maternal recognition of pregnancy, thrombospondin 1.
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