Age-associated deterioration in follicular fluid induces a decline in bovine oocyte quality
Shun Takeo A , Koji Kimura B , Koumei Shirasuna A , Takehito Kuwayama A and Hisataka Iwata A C
+ Author Affiliations
- Author Affiliations
A Tokyo University of Agriculture, Funako 1737, Atsugi Kanagawa 243-0034, Japan.
B Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama 700-8530, Japan.
C Corresponding author. Email: h1iwata@nodai.ac.jp
Reproduction, Fertility and Development 29(4) 759-767 https://doi.org/10.1071/RD15228
Submitted: 7 June 2015 Accepted: 26 November 2015 Published: 2 February 2016
Abstract
Maternal age affects the quality of oocytes. The present study examined whether follicular fluid (FF) is a casual factor for age-associated decline in oocyte quality. First, we measured the concentration of advanced glycation end-products (AGE) in FF derived from young (21–45 months; Young-FF) and aged (≥120 months; Aged-FF) cows and found significantly higher concentrations of AGE in Aged-FF than Young-FF. Second, oocytes were collected from ovaries of young or aged cows and cultured in maturation medium containing 10% FF derived from young or aged cows. Regardless of oocyte origin, Aged-FF accelerated nuclear maturation progression and gap junction closure between oocytes and cumulus cells, increased reactive oxygen species (ROS) content and the rate of abnormal fertilisation of oocytes and decreased blastulation rate compared with Young-FF. Furthermore, supplementation of maturation medium with AGE induced similar age-associated events in oocytes derived from young cows, in that AGE accelerated the progression of nuclear maturation, increased ROS content in oocytes, increased the rate of abnormal fertilisation and decreased blastulation rate. In conclusion, maternal aging increased the concentration of AGE in FF, and both AGE and Aged-FF accelerated nuclear maturation and reduced the developmental competence of oocytes.
Additional keywords: advanced glycation end-products, cow, maternal aging.
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