Actin crosslinking protein filamin A during early pregnancy in the rat uterus
Romanthi J. Madawala A B C , Connie E. Poon A B , Samson N. Dowland A B and Christopher R. Murphy A B
+ Author Affiliations
- Author Affiliations
A Department of Anatomy and Histology, N364 Cell and Reproductive Laboratory, Anderson Stuart Building (F13), The University of Sydney, Sydney, NSW 2006, Australia.
B Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia.
C Corresponding author. Email: romi@anatomy.usyd.edu.au
Reproduction, Fertility and Development 28(7) 960-968 https://doi.org/10.1071/RD14240
Submitted: 8 July 2014 Accepted: 13 November 2014 Published: 5 January 2015
Abstract
During early pregnancy the endometrium undergoes a major transformation in order for it to become receptive to blastocyst implantation. The actin cytoskeleton and plasma membrane of luminal uterine epithelial cells (UECs) and the underlying stromal cells undergo dramatic remodelling to facilitate these changes. Filamin A (FLNA), a protein that crosslinks actin filaments and also mediates the anchorage of membrane proteins to the actin cytoskeleton, was investigated in the rat uterus at fertilisation (Day 1) and implantation (Day 6) to determine the role of FLNA in actin cytoskeletal remodelling of UECs and decidua during early pregnancy. Localisation of FLNA in UECs at the time of fertilisation was cytoplasmic, whilst at implantation it was distributed apically; its localisation is under the influence of progesterone. FLNA was also concentrated to the first two to three stromal cell layers at the time of fertilisation and shifted to the primary decidualisation zone at the time of implantation. This shift in localisation was found to be dependent on the decidualisation reaction. Protein abundance of the FLNA 280-kDa monomer and calpain-cleaved fragment (240 kDa) did not change during early pregnancy in UECs. Since major actin cytoskeletal remodelling occurs during early pregnancy in UECs and in decidual cells, the changing localisation of FLNA suggests that it may be an important regulator of cytoskeletal remodelling of these cells to allow uterine receptivity and decidualisation necessary for implantation in the rat.
Additional keywords: actin binding, actin remodeling, decidualisation, ovarian hormone, uterine receptivity.
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