Role of Wnt signalling in early pregnancy
Sarmah B. Nayeem A B , Frank Arfuso B C , Arun Dharmarajan B C and Jeffrey A. Keelan A D
+ Author Affiliations
- Author Affiliations
A School of Women’s and Infant’s Health, University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia.
B School of Anatomy, Physiology and Human Biology, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
C School of Biomedical Sciences, Curtin University, Kent Street, Bentley, WA 6845, Australia.
D Corresponding author. Email: jeff.keelan@uwa.edu.au
Reproduction, Fertility and Development 28(5) 525-544 https://doi.org/10.1071/RD14079
Submitted: 27 February 2014 Accepted: 5 August 2014 Published: 5 September 2014
Abstract
The integration of a complex network of signalling molecules promotes implantation of the blastocyst and development of the placenta. These processes are crucial for a successful pregnancy and fetal growth and development. The signalling network involves both cell–cell and cell–extracellular matrix communication. The family of secreted glycoprotein ligands, the Wnts, plays a major role in regulating a wide range of biological processes, including embryonic development, cell fate, proliferation, migration, stem cell maintenance, tumour suppression, oncogenesis and tissue homeostasis. Recent studies have provided evidence that Wnt signalling pathways play an important role in reproductive tissues and in early pregnancy events. The focus of this review is to summarise our present knowledge of expression, regulation and function of the Wnt signalling pathways in early pregnancy events of human and other model systems, and its association with pathological conditions. Despite our recent progress, much remains to be learned about Wnt signalling in human reproduction. The advancement of knowledge in this area has applications in the reduction of infertility and the incidence and morbidity of gestational diseases.
Additional keywords: decidua, endometrium, placenta, trophoblast.
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