Environmental regulation of placental phenotype: implications for fetal growth
O. R. Vaughan A B , A. N. Sferruzzi-Perri A , P. M. Coan A and A. L. Fowden A
+ Author Affiliations
- Author Affiliations
A Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
B Corresponding author. Email: orv20@cam.ac.uk
Reproduction, Fertility and Development 24(1) 80-96 https://doi.org/10.1071/RD11909
Published: 6 December 2011
Abstract
Environmental conditions during pregnancy determine birthweight, neonatal viability and adult phenotype in human and other animals. In part, these effects may be mediated by the placenta, the principal source of nutrients for fetal development. However, little is known about the environmental regulation of placental phenotype. Generally, placental weight is reduced during suboptimal conditions like maternal malnutrition or hypoxaemia but compensatory adaptations can occur in placental nutrient transport capacity to help maintain fetal growth. In vivo studies show that transplacental glucose and amino acid transfer adapt to the prevailing conditions induced by manipulating maternal calorie intake, dietary composition and hormone exposure. These adaptations are due to changes in placental morphology, metabolism and/or abundance of specific nutrient transporters. This review examines environmental programming of placental phenotype with particular emphasis on placental nutrient transport capacity and its implications for fetal growth, mainly in rodents. It also considers the systemic, cellular and molecular mechanisms involved in signalling environmental cues to the placenta. Ultimately, the ability of the placenta to balance the competing interests of mother and fetus in resource allocation may determine not only the success of pregnancy in producing viable neonates but also the long-term health of the offspring.
Additional keywords: developmental programming, epigenetics, glucocorticoids, insulin-like growth factors, nutrition, system A.
References
Ahokas, R. A., Lahaye, E. B., Anderson, G. D., and Lipshitz, J. (1981). Effect of maternal dietary restriction on fetal growth and placental transfer of alpha-amino isobutyric acid in rats. J. Nutr. 111, 2052–2058.| 1:CAS:528:DyaL38Xjtlyntw%3D%3D&md5=e758060dac8d1b3375e3fda3c9031502CAS |
Ahokas, R. A., Anderson, G. D., and Lipshitz, J. (1983). Effect of dietary restriction, during the last week only or throughout gestation, on cardiac output and uteroplacental blood flow in pregnant rats. J. Nutr. 113, 1766–1776.
| 1:STN:280:DyaL3s3ptlKgtw%3D%3D&md5=d8bb3c25ab83056c0e9abb5338206783CAS |
Ain, R. (2005). Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway. J. Endocrinol. 185, 253–263.
| Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXktlylt7k%3D&md5=3424afcec5e5565b5f22c6aefc4e49aaCAS |
W. R., Allen, Short, , and R. V., (1997). Interspecific and extraspecific pregnancies in equids: Anything goes. J. Hered. 88, 384–392.
Allen, W. R., Wilsher, S., Turnbull, C., Stewart, F., Ousey, J., Rossdale, P. D., and Fowden, A. L. (2002). The influence of maternal size on placental, fetal and postnatal growth in the horse: I Development in utero. Reproduction 123, 445–453.
| The influence of maternal size on placental, fetal and postnatal growth in the horse: I Development in utero.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xit1Cls70%3D&md5=a86258752fc9c54a284a8818e36690f8CAS |
Angiolini, E., Coan, P. M., Sandovici, I., Iwajomo, O. H., Peck, G., Burton, G. J., Sibley, C. P., Reik, W., Fowden, A. L., and Constancia, M. (2011). Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth. FASEB J. 25, 1737–1745.
| Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXlvFSmur4%3D&md5=c4c0b5073f46f7292329a682df87f1daCAS |
Armitage, J. A., Khan, I. Y., Taylor, P. D., Nathanielsz, P. W., and Poston, L. (2004). Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J. Physiol. 561, 355–377.
| Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhtFait7zP&md5=3654309a7ec5e4cb110476b31ccd91a1CAS |
Arroyo, JA, Brown, LD, and Galan, HL (2009). Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol 201, 616.e1–616.e7.
| Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction.Crossref | GoogleScholarGoogle Scholar |
Atkinson, D. E., Robinson, N. R., and Sibley, C. P. (1991). Development of passive permeability characteristics of rat placenta during the last third of gestation. Am. J. Physiol. 261, R1461–R1464.
| 1:STN:280:DyaK38%2Fosl2qsQ%3D%3D&md5=fa2a41c9b3be6e3d6bda6530ab976eeaCAS |
Audette, M. C., Challis, J. R. G., Jones, R. L., Sibley, C. P., and Matthews, S. G. (2011). Antenatal dexamethasone treatment in midgestation reduces System A-mediated transport in late gestation murine placenta. Endocrinology 152, .
| Antenatal dexamethasone treatment in midgestation reduces System A-mediated transport in late gestation murine placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtFOht7fP&md5=9fe363296c811f9b1803751681303b53CAS |
Bacon, B. J., Gilbert, R. D., Kaufmann, P., Smith, A. D., Trevino, F. T., and Longo, L. D. (1984). Placental anatomy and diffusing capacity in guinea pigs following long-term maternal hypoxia. Placenta 5, 475–487.
| Placental anatomy and diffusing capacity in guinea pigs following long-term maternal hypoxia.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL2M7ktVSmtA%3D%3D&md5=0937b40a036049036ff42008eac5ae54CAS |
Baker, J., Liu, J. P., Robertson, E. J., and Efstratiadis, A. (1993). Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73–82.
| 1:CAS:528:DyaK3sXms1entLs%3D&md5=e1e82cea1fd3a8417e9cf09c21b98cdfCAS |
Barker, D. J. (2004). The developmental origins of adult disease. J. Am. Coll. Nutr. 23, 588S–595S.
| 1:STN:280:DC%2BD2M%2FhsVSgtA%3D%3D&md5=3935d3bb58af50cbb7126b93964c2af3CAS |
Battaglia, F. C., and Regnault, T. R. (2001). Placental transport and metabolism of amino acids. Placenta 22, 145–161.
| Placental transport and metabolism of amino acids.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXhsFWqtbo%3D&md5=bd696327ae2711cbd53ce08c862d89e0CAS |
Belkacemi, L., Jelks, A., Chen, C.-C., Ross, M. G., and Desai, M. (2011). Altered placental development in undernourished rats: role of maternal glucocorticoids. Reprod. Biol. Endocrinol. 9, 105.
| Altered placental development in undernourished rats: role of maternal glucocorticoids.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtFGktr3O&md5=16ddb921cd1682316d3b364f8dc96a55CAS |
Bertolini, M., and Anderson, G. B. (2002). The placenta as a contributor to production of large calves. Theriogenology 57, 181–187.
| The placenta as a contributor to production of large calves.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD38%2Fksl2mtQ%3D%3D&md5=71773a1ad10a1d5053989a0c61f64664CAS |
Bertolini, M., Mason, J. B., Beam, S. W., Carneiro, G. F., Sween, M. L., Kominek, D. J., Moyer, A. L., Famula, T. R., Sainz, R. D., and Anderson, G. B. (2002). Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights. Theriogenology 58, 973–994.
| Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights.Crossref | GoogleScholarGoogle Scholar |
Bourque, D. K., Avila, L., Penaherrera, M., von Dadelszen, P., and Robinson, W. P. (2010). Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia. Placenta 31, 197–202.
| Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXit1Khsrs%3D&md5=6b29be7ffbbbcca36263580c0cea9b16CAS |
Burton, P. J., and Waddell, B. J. (1999). Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol. Reprod. 60, 234–240.
| Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXotlyisQ%3D%3D&md5=d4cd30556a32bf25f67ba1fcf77f819bCAS |
Camm, E. J., Hansell, J. A., Kane, A. D., Herrera, E. A., Lewis, C., Wong, S., Morrell, N. W., and Giussani, D. A. (2010). Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function. Am. J. Obstet. Gynecol. 203, 495.e424–495.e34.
| Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function.Crossref | GoogleScholarGoogle Scholar |
Cleal, J. K., and Lewis, R. M. (2008). The mechanisms and regulation of placental amino acid transport to the human foetus. J. Neuroendocrinol. 20, 419–426.
| The mechanisms and regulation of placental amino acid transport to the human foetus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXkslyguro%3D&md5=5b1c3928379faca60dc2b34ae2128039CAS |
Clifton, V. L. (2010). Review: Sex and the human placenta: mediating differential strategies of fetal growth and survival. Placenta 31, S33–S39.
| Review: Sex and the human placenta: mediating differential strategies of fetal growth and survival.Crossref | GoogleScholarGoogle Scholar |
Coan, P. M., Angiolini, E., Sandovici, I., Burton, G. J., Constancia, M., and Fowden, A. L. (2008a). Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice. J. Physiol. 586, 4567–4576.
| Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1SnsLrE&md5=1ebb0e2dc077a3f3a3a232dc7cad4089CAS |
Coan, P. M., Fowden, A. L., Constancia, M., Ferguson-Smith, A. C., Burton, G. J., and Sibley, C. P. (2008b). Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse. J. Physiol. 586, 5023–5032.
| Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtlamur%2FO&md5=54da9d7e7614879c45aa9fdab88c33e0CAS |
Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., and Fowden, A. L. (2010). Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. J. Physiol. 588, 527–538.
| Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhvV2js7o%3D&md5=6f058a9616d83f3c21c182ce8b4fca8dCAS |
Coan, P. M., Vaughan, O. R., McCarthy, J., Mactier, C., Burton, G. J., Constancia, M., and Fowden, A. L. (2011). Dietary composition programmes placental phenotype in mice. J. Physiol. 589, 3659–3670.
| Dietary composition programmes placental phenotype in mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXpsl2qu74%3D&md5=9ca8e96f8c58a0a243d9daf2844ac3b0CAS |
Constancia, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., and Reik, W. (2002). Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 417, 945–948.
| Placental-specific IGF-II is a major modulator of placental and fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XkvVagsbw%3D&md5=34be6d1de5b89e2957d9f42dc8f15437CAS |
Constancia, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., and Fowden, A. (2005). Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc. Natl Acad. Sci. USA 102, 19 219–19 224.
| Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XivV2msw%3D%3D&md5=b5b5a476ef5a1be807e2fdaec6dbf261CAS |
Constant, F., Guillomot, M., Heyman, Y., Vigon, X., Laigre, P., Servely, J. L., Renard, J. P., and Chavatte-Palmer, P. (2006). Large offspring or large placenta? Morphometric analysis of late gestation bovine placentomes from somatic nuclear transfer pregnancies complicated by hydrallantois. Biol. Reprod. 78, 123–130.
Cramer, S., Beveridge, M., Kilberg, M., and Novak, D. (2002). Physiological importance of system A-mediated amino acid transport to rat fetal development. Am. J. Physiol. Cell Physiol. 282, C153–C160.
| 1:CAS:528:DC%2BD38XlsVKnuw%3D%3D&md5=c87018aceb18a08e710cc693c251e436CAS |
Crowe, C., Dandekar, P., Fox, M., Dhingra, K., Bennet, L., and Hanson, M. A. (1995). The effects of anaemia on heart, placenta and body weight, and blood pressure in fetal and neonatal rats. J. Physiol. 488, 515–519.
| 1:CAS:528:DyaK2MXptFGnt78%3D&md5=817d6acd312c70b6b2d0df46cd9bc08eCAS |
Cui, X. S., Zhang, D. X., Ko, Y. G., and Kim, N. H. (2009). Aberrant epigenetic reprogramming of imprinted microRNA-127 and Rtl1 in cloned mouse embryos. Biochem. Biophys. Res. Commun. 379, 390–394.
| Aberrant epigenetic reprogramming of imprinted microRNA-127 and Rtl1 in cloned mouse embryos.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXotl2jtA%3D%3D&md5=2b6aa2ba8cc5f369f51832889a82bb7dCAS |
Curchoe, C. L., Zhang, S., Yang, L., Page, R., and Tian, C. (2009). Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle. Anim. Reprod. Sci. 116, 213–225.
| Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtlWnsrfJ&md5=31ddc588fbf42eb8781781db849bbbe4CAS |
Das, U. G., Sadiq, H. F., Soares, M. J., Hay, W. W., and Devaskar, S. U. (1998). Time-dependent physiological regulation of rodent and ovine placental glucose transporter (GLUT-1) protein. Am. J. Physiol. 274, R339–R347.
| 1:CAS:528:DyaK1cXht1Cmtbw%3D&md5=60fb4d0ce70ce77a3d73267bcebcbdf6CAS |
Delle Piane, L., Lin, W., Liu, X., Donjacour, A., Minasi, P., Revelli, A., Maltepe, E., and Rinaudo, P. F. (2010). Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model. Hum. Reprod. 25, 2039–2046.
| Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3cnos1ensQ%3D%3D&md5=c7506a4591ba01023d29f76545c927e9CAS |
Desforges, M., and Sibley, C. P. (2010). Placental nutrient supply and fetal growth. Int. J. Dev. Biol. 54, 377–390.
| Placental nutrient supply and fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXltVajur8%3D&md5=0d0b0d04f050b72a2a6309cd4c22d4bbCAS |
Desoye, G., Gauster,, M., and Wadsack,, C. (2011). Placental transport in pregnancy pathologies. Am. J. Clin. Nutr. , .
| Placental transport in pregnancy pathologies.Crossref | GoogleScholarGoogle Scholar |
Doherty, C., Lewis, R. M., Sharkey, A., and Burton, G. J. (2003). Placental composition and surface area but not vascularization are altered by maternal protein restriction in the rat. Placenta 24, 34–38.
| Placental composition and surface area but not vascularization are altered by maternal protein restriction in the rat.Crossref | GoogleScholarGoogle Scholar |
Elliott, C., Morton, J., and Chopin, J. (2009). Factors affecting foal birth weight in Thoroughbred horses. Theriogenology 71, 683–689.
| Factors affecting foal birth weight in Thoroughbred horses.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1M%2Fpt1yjtA%3D%3D&md5=7c191bfe795b27ff20ef658e110357d0CAS |
Eriksson, J. G., Kajantie, E., Osmond, C., Thornburg, K., and Barker, D. J. P. (2009). Boys live dangerously in the womb. Am. J. Human Biol 22, 330–335.
| Boys live dangerously in the womb.Crossref | GoogleScholarGoogle Scholar |
Farin, P. W., Piedrahita, J. A., and Farin, C. E. (2006). Errors in development of fetuses and placentas from in vitro-produced bovine embryos. Theriogenology 65, 178–191.
| Errors in development of fetuses and placentas from in vitro-produced bovine embryos.Crossref | GoogleScholarGoogle Scholar |
Fingar, D. C., and Blenis, J. (2004). Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23, 3151–3171.
| Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXjtFOmsb8%3D&md5=128a7a312cb53dab74611df1686bdb35CAS |
Fletcher, C. J., Roberts, C. T., Hartwich, K. M., Walker, S. K., and McMillen, I. C. (2007). Somatic cell nuclear transfer in the sheep induced placental defects that likely precede fetal demise. Reproduction 133, 243–255.
| Somatic cell nuclear transfer in the sheep induced placental defects that likely precede fetal demise.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjs1aisrg%3D&md5=cdb3ccbce8a4a7e6e752c2a6c39d30feCAS |
Forhead, A. J., and Fowden, A. L. (2009). The hungry fetus? Role of leptin as a nutritional signal before birth. J. Physiol. 587, 1145–1152.
| The hungry fetus? Role of leptin as a nutritional signal before birth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXnt1GntL4%3D&md5=ce727f6342dfc2d096892d5b7b9c69dcCAS |
Fortier, A. L., Lopes, F. L., Darricarrere, N., Martel, J., and Trasler, J. M. (2008). Superovulation alters the expression of imprinted genes in the midgestation mouse placenta. Hum. Mol. Genet. 17, 1653–1665.
| Superovulation alters the expression of imprinted genes in the midgestation mouse placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmvFSrtL8%3D&md5=f1e27c0a7f3303d05bf90e2f7af6d9aaCAS |
Fowden, A. L. (2003). The insulin-like growth factors and feto-placental growth. Placenta 24, 803–812.
| The insulin-like growth factors and feto-placental growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXnt1amtb4%3D&md5=7b564b7b73c5ca2072b58c68ef29eadaCAS |
Fowden, A. L., and Forhead, A. J. (2009a). Endocrine regulation of feto-placental growth. Horm. Res. 72, 257–265.
| Endocrine regulation of feto-placental growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXht12hurjJ&md5=b923135dd418ad9987001725fcc5752eCAS |
Fowden, A. L., and Forhead, A. J. (2009b). Hormones as epigenetic signals in developmental programming. Exp. Physiol. 94, 607–625.
| Hormones as epigenetic signals in developmental programming.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXnvVOqt7c%3D&md5=f8117fd2ae864f830973ab0775682a70CAS |
Fowden, A. L., Ralph, M. M., and Silver, M. (1994). Nutritional regulation of uteroplacental prostaglandin production and metabolism in pregnant ewes and mares during late gestation. Exp. Clin. Endocrinol. 102, 212–221.
| Nutritional regulation of uteroplacental prostaglandin production and metabolism in pregnant ewes and mares during late gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXlsV2hsb8%3D&md5=a9ca463be928aa7b560ef3617506e961CAS |
Fowden, A. L., Li, J., and Forhead, A. J. (1998). Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance? Proc. Nutr. Soc. 57, 113–122.
| Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXivVWht78%3D&md5=6c70378651be7ba4ccbeebe3165933c6CAS |
Fowden, A. L., Sibley, C., Reik, W., and Constancia, M. (2006a). Imprinted genes, placental development and fetal growth. Horm. Res. 65, 50–58.
| Imprinted genes, placental development and fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XksV2isb0%3D&md5=2cee991562de3fd3c813f1a6846af588CAS |
Fowden, A. L., Ward, J. W., Wooding, F. P., Forhead, A. J., and Constancia, M. (2006b). Programming placental nutrient transport capacity. J. Physiol. 572, 5–15.
| 1:CAS:528:DC%2BD28Xkt1GhtLw%3D&md5=da403a36cc4f302a08f22d6f2b3a902cCAS |
Fowden, A. L., Giussani, D. A., and Forhead, A. J. (2006c). Intrauterine programming of physiological systems: causes and consequences. Physiology 21, 29–37.
| 1:CAS:528:DC%2BD28XitVWlsrs%3D&md5=af2bfe422501922ce77cd6b34da0d0caCAS |
Fowden, A. L., Forhead, A. J., Coan, P. M., and Burton, G. J. (2008). The placenta and intrauterine programming. J. Neuroendocrinol. 20, 439–450.
| The placenta and intrauterine programming.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXkslygurc%3D&md5=66ccc297ad013520a0aae62f3dcaa496CAS |
Fowden, A. L., Sferruzzi-Perri, A. N., Coan, P. M., Constancia, M., and Burton, G. J. (2009). Placental efficiency and adaptation: Endocrine regulation. J. Physiol. 587, 3459–3472.
| Placental efficiency and adaptation: Endocrine regulation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXpt1Wrs7s%3D&md5=f80023e673c4b5a53c767d2755d2de6bCAS |
Fowden, A. L., Ward, J. W., Wooding, F. B. P., and Forhead, A. J. (2010). Developmental programming of the ovine placenta. Soc. Reprod. Fertil. 67, 41–57.
| 1:STN:280:DC%2BC3MnosFegsA%3D%3D&md5=113088924dcb7541be5600aec5094fceCAS |
Fowden, A. L., Coan, P. M., Angiolini, E., Burton, G. J., and Constancia, M. (2011). Imprinted genes and the epigenetic regulation of placental phenotype. Prog. Biophys. Mol. Biol. 106, 281–288.
| Imprinted genes and the epigenetic regulation of placental phenotype.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXntFKgtrk%3D&md5=d95fe8ca93af95354856437a9b55b55eCAS |
Fu, Q., Yu, X., Callaway, C. W., Lane, R. H., and McKnight, R. A. (2009). Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene. FASEB J. 23, 2438–2449.
| Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXpvFOltr0%3D&md5=de5d8b411a5d56b671f40b3ba6005cd3CAS |
Gallou-Kabani, C., Gabory, A., Tost, J., Karimi, M., Mayeur, S., Lesage, J., Boudadi, E., Gross, M. S., Taurelle, J., Vige, A., Breton, C., Reusens, B., Remacle, C., Vieau, D., Ekstrom, T. J., Jais, J. P., and Junien, C. (2010). Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS ONE 5, e14398.
| Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXisFahsw%3D%3D&md5=d85807b4389c11a4481f3551e2878cc1CAS |
Garrett, R. J. (1975). Nicotine and placental iron transport. Experientia 31, 486–488.
| Nicotine and placental iron transport.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2MXlt1Ojsbo%3D&md5=c5b9d965cec42d7ba97c88ee5aa41190CAS |
Gilbert, M., and Leturque, A. (1982). Fetal weight and its relationship to placental blood flow and placental weight in experimental intrauterine growth retardation in the rat. J. Dev. Physiol. 4, 237–246.
| 1:STN:280:DyaL3s%2FotlymsA%3D%3D&md5=aeb2b1fabb2cbc727003ffce1539a789CAS |
Gilbert, R. D., Cummings, L. A., Juchau, M. R., and Longo, L. D. (1979). Placental diffusing capacity and fetal development in exercising or hypoxic guinea pigs. J. Appl. Physiol. 46, 828–834.
| 1:CAS:528:DyaE1MXitVWnsbo%3D&md5=16155ce7ea6253d301943b60f6295e51CAS |
Goyal, R., Lister, R., Leitzke, A., Goyal, D., Gheorghe, C. P., and Longo, L. D. (2011). Antenatal maternal hypoxic stress: adaptations of the placental renin–angiotensin system in the mouse. Placenta 32, 134–139.
| Antenatal maternal hypoxic stress: adaptations of the placental renin–angiotensin system in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhvFWntbc%3D&md5=e5ba1a3b80d396a401c6bc673a5e3226CAS |
Guillomot, M., Taghouti, G., Constant, F., Degrelle, S., Hue, I., Chavatte-Palmer, P., and Jammes, H. (2010). Abnormal expression of the imprinted gene Phlda2 in cloned bovine placenta. Placenta 31, 482–490.
| Abnormal expression of the imprinted gene Phlda2 in cloned bovine placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmvVWruro%3D&md5=72ffc56e434e76ceffc97034bfe17038CAS |
Gundogan, F., Elwood, G., Longato, L., Tong, M., Feijoo, A., Carlson, R. I., Wands, J. R., and de la Monte, S. M. (2008). Impaired placentation in fetal alcohol syndrome. Placenta 29, 148–157.
| Impaired placentation in fetal alcohol syndrome.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhsVylsbc%3D&md5=b269ffd2088b0e81e1e9fd6c43907289CAS |
Hahn, T., Barth, S., Graf, R., Engelmann, M., Beslagic, D., Reul, J. M., Holsboer, F., Dohr, G., and Desoye, G. (1999). Placental glucose transporter expression is regulated by glucocorticoids. J. Clin. Endocrinol. Metab. 84, 1445–1452.
| Placental glucose transporter expression is regulated by glucocorticoids.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXisVyrtbw%3D&md5=92af5b2e6908a0c25021a2656564e6b4CAS |
Handwerger, S., and Freemark, M. (2000). The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development. J. Pediatr. Endocrinol. Metab. 13, 343–356.
| The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3c3js1OntA%3D%3D&md5=bb81abcfcabb10f28f7dcf2604c07d68CAS |
Hanson, M. A., and Gluckman, P. D. (2008). Developmental origins of health and disease: new insights. Basic Clin. Pharmacol. Toxicol. 102, 90–93.
| Developmental origins of health and disease: new insights.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhvF2gsrY%3D&md5=3f21a4ffa459b343c692a8d32c3cc917CAS |
Hashizume, K., Ishiwata, H., Kizaki, K., Yamada, O., Takahashi, T., Imai, K., Patel, O. V., Akaqi, S., Shimizu, M., Takahashi, S., Katsuma, S., Shiojima, S., Hirasawa, A., Tsujimoto, G., Todoroki, J., and Izaike, I. (2002). Implantation and placental development in somatic cell clone recipient cows. Cloning Stem Cells 4, 197–209.
| Implantation and placental development in somatic cell clone recipient cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XnvFSksrg%3D&md5=7373c8e0945f15ec9bcdf9f13236664dCAS |
Haycock, P. C., and Ramsay, M. (2009). Exposure of mouse embryos to ethanol during preimplantation development: effect on DNA methylation in the H19 imprinting control region. Biol. Reprod. 81, 618–627.
| Exposure of mouse embryos to ethanol during preimplantation development: effect on DNA methylation in the H19 imprinting control region.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtFyhsLjO&md5=1188ca5976d97f6b51b788295ac44cfcCAS |
Hewitt, D. P., Mark, P. J., and Waddell, B. J. (2006). Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat. Endocrinology 147, 5568–5574.
| Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xht1yqtr7M&md5=b45236a4d429533ca0308bee9df9c609CAS |
Hill, J. R., Burghardt, R. C., Jones, K., Long, C. R., Looney, C. R., Shin, T., Spencer, T. E., Thompson, J. A., Winger, Q. A., and Westhusin, M. E. (2000). Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine foetuses. Biol. Reprod. 63, 1787–1794.
| Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine foetuses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXosVKhtL4%3D&md5=a0fe8919a46af7cfe7a3ebc5ac55229cCAS |
Hvizdošová-Kleščová, A., Uhlík, J., Malina, M., Vulterinová, H., Novotný, T., and Vajner, L. (2011). Remodelin of feto-placental arteries in rats due to chroniv hypoxia. Exp. Toxicol. Pathol. , .
| Remodelin of feto-placental arteries in rats due to chroniv hypoxia.Crossref | GoogleScholarGoogle Scholar |
Illsley, N. P., Caniggia, I., and Zamudio, S. (2010). Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth? Int. J. Dev. Biol. 54, 409–419.
| Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXltVajuro%3D&md5=7776ad28065cdde60e414a89d92204a3CAS |
Irani, R. A., and Xia, Y. (2008). The functional role of the renin-angiotensin system in pregnancy and preeclampsia. Placenta 29, 763–771.
| The functional role of the renin-angiotensin system in pregnancy and preeclampsia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtVOhsrvK&md5=23415fe5bec5547ab0e64b9949e7d3f7CAS |
Jansson, N., Greenwood, S. L., Johansson, B. R., Powell, T. L., and Jansson, T. (2003). Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments. J. Clin. Endocrinol. Metab. 88, 1205–1211.
| Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXit1ensrg%3D&md5=7664914102715d215233d71588018968CAS |
Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., and Jansson, T. (2006). Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J. Physiol. 576, 935–946.
| 1:CAS:528:DC%2BD28Xht1yjt77O&md5=8675254fd97dabc0a8150587658af67cCAS |
Jauniaux, E., and Burton, G. J. (2007). Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. Early Hum. Dev. 83, 699–706.
| Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXht1aktbbJ&md5=28aac685e613f9bd6330ac1354570cd2CAS |
Jones, H. N., Woollett, L. A., Barbour, N., Prasad, P. D., Powell, T. L., and Jansson, T. (2009). High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J. 23, 271–278.
| High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXlsVOktA%3D%3D&md5=cda5b74ddbe96feb2fab680cbd15f532CAS |
Kalabis, G. M. (2005). Multidrug resistance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection. Biol. Reprod. 73, 591–597.
| Multidrug resistance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtVCgtrrJ&md5=5f659cabbdeba230ad7d0aeeb272526eCAS |
Kalabis, G., Petropoulos, S., Gibb, W., and Matthews, S. (2007). Breast cancer resistance protein (Bcrp1/Abcg2) in mouse placenta and yolk sac: ontogeny and its regulation by progesterone. Placenta 28, 1073–1081.
| Breast cancer resistance protein (Bcrp1/Abcg2) in mouse placenta and yolk sac: ontogeny and its regulation by progesterone.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtVWmsLnN&md5=b28ffd9c5123286d65f9d2c19744565eCAS |
Keesey, R. E., and Hirvonen, M. D. (1997). Body weight set-points: determination and adjustment. J. Nutr. 127, 1875S–1883S.
| 1:CAS:528:DyaK2sXlvFGmsbY%3D&md5=2594cad7c6650058e2d007b199cd1fd6CAS |
Khosla, S., Dean, W., Brown, D., Reik, W., and Feil, R. (2001). Culture of preimplanation mouse embryos affects fetal development and the expression of imprinted genes. Biol. Reprod. 64, 918–926.
| Culture of preimplanation mouse embryos affects fetal development and the expression of imprinted genes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXhsVKjtrc%3D&md5=5d56b15a518d832fa865745fddf0eb9bCAS |
Kohan-Ghadr, H. R., Lefebvre, R. C., Fecteau, G., Smith, L. C., Murphy, B. D., Suzuki, J. J., Girard, C., and Helie, P. (2008). Ultrasonographic and histological characterization of the placenta of somatic nuclear transfer-derived pregnancies in dairy cattle. Theriogenology 69, 218–230.
| Ultrasonographic and histological characterization of the placenta of somatic nuclear transfer-derived pregnancies in dairy cattle.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2sjmslCrtg%3D%3D&md5=2d5a65d869456facf38881d57c86412bCAS |
Koukoura, O., Sifakis, S., Zaravinos, A., Apostolidou, S., Jones, A., Hajiioannou, J., Widschwendter, M., and Spandidos, D. A. (2011). Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction. Placenta 32, 51–57.
| Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhsF2isr%2FO&md5=704bbc14418a8bf7a80f031c48174adfCAS |
Kubisch, H. M., Ratterree, M. S., Williaams, V. M., Johson, K. M., Davison, B. B., Phillippi-Falkenstein, K. M., and Harrison, R. M. (2005). Birth of Rhesus macaque (Macaca mulatta) infabts after in vitro fertilization and gestation in feamle or pigtailed (Macaa nemestrina) macques. Comp. Med. 55, 129–135.
| 1:CAS:528:DC%2BD2MXhtFGju7%2FN&md5=5c76ce4cfaad203e604b3365fd0d468fCAS |
Kulkarni, A., Dangat, K., Kale, A., Sable, P., Chavan-Gautam, P., and Joshi, S. (2011). Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS ONE 6, e17706.
| Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXjslKlsrw%3D&md5=1509f523b2879278cfcf63c70ad6c075CAS |
Kurz, H., Zechner, U., Orth, A., and Fundele, R. (1999). Lack of correlation between placenta and offspring size in mouse interspecific crosses. Anat. Embryol. (Berl.) 200, 335–343.
| Lack of correlation between placenta and offspring size in mouse interspecific crosses.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1MzptV2ruw%3D%3D&md5=5dc8eba255afe5109e2387a21cd2cb5dCAS |
Langdown, M. L., and Sugden, M. C. (2001). Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Mol. Cell. Endocrinol. 185, 109–117.
| Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXovFyqtLs%3D&md5=666d64418da8a460347aacb41002fda6CAS |
Langley-Evans, S. C., Langley-Evans, A. J., and Marchand, M. C. (2003). Nutritional programming of blood pressure and renal morphology. Arch. Physiol. Biochem. 111, 8–16.
| Nutritional programming of blood pressure and renal morphology.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXis1akt7o%3D&md5=c00d6af81740e65aa0fa25b5b44f126aCAS |
Lee, S. Y., Park, J. K., Choi, Y. J., Cho, S. K., Ahn, J. D., Kwon, D. N., Hwang, K. C., Kang, S. J., Paik, S. S., Seo, H. G., Lee, H. T., and Kim, J. H. (2007). Comparative proteomic analysis associated with term placental insufficiency in cloned pig. Proteomics 7, 1303–1315.
| Comparative proteomic analysis associated with term placental insufficiency in cloned pig.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXlsVWqurw%3D&md5=ce1763a5e7f7ac36eba19fe8fbe00344CAS |
Lee, Y. E., Byun, S. K., Shin, S., Jang, J. Y., Choi, B. I., Park, D., Jeon, J. H., Nahm, S. S., Kang, J. K., Hwang, S. Y., Kim, J. C., and Kim, Y. B. (2008). Effect of maternal restraint stress on fetal development of ICR mice. Exp. Anim. 57, 19–25.
| Effect of maternal restraint stress on fetal development of ICR mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXivFeqs7c%3D&md5=56e06dfce7436158b4958478260e91c3CAS |
Lesage, J., Blondeau, B., Grino, M., Breant, B., and Dupouy, J. P. (2001). Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 142, 1692–1702.
| Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXjt1aktrs%3D&md5=689a6b6174d96c700247df6c9efd9174CAS |
Lesage, J., Hahn, D., Leonhardt, M., Blondeau, B., Breant, B., and Dupouy, J. P. (2002). Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels. J. Endocrinol. 174, 37–43.
| Maternal undernutrition during late gestation-induced intrauterine growth restriction in the rat is associated with impaired placental GLUT3 expression, but does not correlate with endogenous corticosterone levels.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XlvFeqtb8%3D&md5=d33cc8576c3a2a4c5384cde8120d6abdCAS |
Lewis, R. M., Doherty, C. B., James, L. A., Burton, G. J., and Hales, C. N. (2001a). Effects of maternal iron restriction on placental vascularization in the rat. Placenta 22, 534–539.
| Effects of maternal iron restriction on placental vascularization in the rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXlvVKgs7s%3D&md5=2f579b41135236ec2866d7f6b495b85eCAS |
Lewis, R. M., James, L. A., Zhang, J., Byrne, C. D., and Hales, C. N. (2001b). Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels. Br. J. Nutr. 85, 193–201.
| Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXisVSktbc%3D&md5=3d4b4d5e2855233f6af55e9621520637CAS |
Lillycrop, K. A., Slater-Jefferies, J. L., Hanson, M. A., Godfrey, K. M., Jackson, A. A., and Burdge, G. C. (2007). Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br. J. Nutr. 97, 1064–1073.
| Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXnt1Gisrs%3D&md5=634526e3647d51204ce173635b576464CAS |
Lin, G. W. (1981). Effect of ethanol feeding during pregnancy on placental transfer of alpha-aminoisobutyric acid in the rat. Life Sci. 28, 595–601.
| Effect of ethanol feeding during pregnancy on placental transfer of alpha-aminoisobutyric acid in the rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3MXpslOmtQ%3D%3D&md5=27e0c8acabdf06cdf58d3e3ed478197bCAS |
Loi, P., Clinton, M., Vackova, I., Fulka, J., Feil, R., Palmieri, C., Della Salda, L., and Ptak, G. (2006). Placental abnormalities associated with post-natal mortaility in sheep somatic cell clones. Theriogenology 65, 1110–1121.
| Placental abnormalities associated with post-natal mortaility in sheep somatic cell clones.Crossref | GoogleScholarGoogle Scholar |
Lueder, F. L., Kim, S. B., Buroker, C. A., Bangalore, S. A., and Ogata, E. S. (1995). Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat. Metabolism 44, 532–537.
| Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXltVersrc%3D&md5=c78c4ad6642b3e12a04d421c62ff2f1fCAS |
Mairesse, J., Lesage, J., Breton, C., Breant, B., Hahn, T., Darnaudery, M., Dickson, S. L., Seckl, J., Blondeau, B., Vieau, D., Maccari, S., and Viltart, O. (2007). Maternal stress alters endocrine function of the feto-placental unit in rats. Am. J. Physiol. Endocrinol. Metab. 292, E1526–E1533.
| Maternal stress alters endocrine function of the feto-placental unit in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmvF2mtrw%3D&md5=73a7b3239965ccd49f78d577d63e3785CAS |
Malandro, M. S., Beveridge, M. J., Kilberg, M. S., and Novak, D. A. (1996a). Effect of low-protein diet-induced intrauterine growth retardation on rat placental amino acid transport. Am. J. Physiol. 271, C295–C303.
| 1:CAS:528:DyaK28Xkslygtrs%3D&md5=b974723034d89f53b330949dbcdbec87CAS |
Malandro, M. S., Beveridge, M. J., Novak, D. A., and Kilberg, M. S. (1996b). Rat placental amino acid transport after protein-deprivation-induced intrauterine growth retardation. Biochem. Soc. Trans. 24, 839–843.
| 1:CAS:528:DyaK28XlslSgu7c%3D&md5=e32e4b42ad2f377f8dc456113c41db16CAS |
Mann, M. R. W., Lee, S. S., Doherty, A. S., Verona, R. I., Nolen, L. D., Schultz, R. M., and Bartolomei, M. S. (2004). Selective loss of imprinting in the placenta following preimplanation development in culture. Development 131, 3727–3735.
| Selective loss of imprinting in the placenta following preimplanation development in culture.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXnt1elt7c%3D&md5=1d324984879367cd72a8a915935c926cCAS |
Mark, P., Sisala, C., Connor, K., Patel, R., Lewis, J. L., Vickers, M. H., Waddell, B. J., and Sloboda, D. M. (2011). A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone but not placental labyrinth zone growth. J. Dev. Origins Health and Disease 2, 63–70.
| A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone but not placental labyrinth zone growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXisVahtLw%3D&md5=cb6100d171477520976619c118d17c51CAS |
McLaren, A. (1965). Genetic and environmental effects on fetal and placental weight in mice. J. Reprod. Fertil. 9, 79–98.
| Genetic and environmental effects on fetal and placental weight in mice.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaF2M%2Fmt1agtA%3D%3D&md5=a7c10e94b0389313fafad5d000dd78f5CAS |
McMillen, I. C., and Robinson, J. S. (2005). Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol. Rev. 85, 571–633.
| Developmental origins of the metabolic syndrome: prediction, plasticity, and programming.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXjt12lsLw%3D&md5=30fe31ba18db36d905badebc689dee4dCAS |
Mellor, D. J. (1983). Nutritional and placental determinants of foetal growth rate in sheep and consequences for the newborn lamb. Br. Vet. J. 139, 307–324.
| 1:STN:280:DyaL3s3osVansg%3D%3D&md5=5c581118a14b097041d7d4546bdca92eCAS |
Memmott, R. M., and Dennis, P. A. (2009). Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell. Signal. 21, 656–664.
| Akt-dependent and -independent mechanisms of mTOR regulation in cancer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXisFWjs7c%3D&md5=c45a291565bb4b7316048df684438398CAS |
Mogami, H., Yura, S., Itoh, H., Kawamura, M., Fujii, T., Suzuki, A., Aoe, S., Ogawa, Y., Sagawa, N., Konishi, I., and Fujii, S. (2009). Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth. Growth Horm. IGF Res. 19, 478–485.
| Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsVGmsbrN&md5=6b5d8e7ac52eae4b1748ccb6919a76a4CAS |
Montano, M. M., Wang, M. H., Even, M. D., and vom Saal, F. S. (1991). Serum corticosterone in fetal mice: sex differences, circadian changes, and effect of maternal stress. Physiol. Behav. 50, 323–329.
| Serum corticosterone in fetal mice: sex differences, circadian changes, and effect of maternal stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXmt1eqs7g%3D&md5=9e10092db10bbe00cce8e7ef0e592acdCAS |
Moore, K., Kramer, J. M., Rodriguez-Sallaberry, C. J., Yelich, J. V., and Drost, M. (2007). Insulin-like growth factor (IGF) family genes are aberrantly expressed in bovine conceptuses produced by in vitro or by nuclear transfer. Theriogenology 68, 717–727.
| Insulin-like growth factor (IGF) family genes are aberrantly expressed in bovine conceptuses produced by in vitro or by nuclear transfer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXos1Sgsrk%3D&md5=4b0736cbc7331cb340900a49c3a1386aCAS |
Morgan, B. L., and Winick, M. (1978). The effects of folic acid supplementation during pregnancy in the rat. Br. J. Nutr. 40, 529–533.
| The effects of folic acid supplementation during pregnancy in the rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE1MXhtlKmsro%3D&md5=39c7287d4753aefdb67e4d7a788600b4CAS |
O’Connell, B. A., Moritz, K. H., Roberts, C. T., Walker, D. W., and Dickinson, H. (2011). The placental response to excess maternal glucocorticoid exposure differs between tha male and female conceptus in spiny mice. Biol. Reprod. , .
| The placental response to excess maternal glucocorticoid exposure differs between tha male and female conceptus in spiny mice.Crossref | GoogleScholarGoogle Scholar |
Ogawa, H., Ono, Y., Shimozawa, N., Sotomaru, Y., Katsuzawa, Y., Hiura, H., Ito, M., and Kono, T. (2003). Disruption of imprinting in cloned mouse foetuses from embryonic stem cells. Reproduction 126, 549–557.
| Disruption of imprinting in cloned mouse foetuses from embryonic stem cells.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXpt1Cksro%3D&md5=4c7b1f0c16cd50bc57078bea98a3239bCAS |
Palmieri, C., Loi, P., Ptak, G., and Della Salda, L. (2008). A review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep and mice. Vet. Pathol. 45, 865–880.
| A review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep and mice.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1cjhvVOqsw%3D%3D&md5=d29129ef09177bd685ccd45c6916c977CAS |
Petropoulos, S., Gibb, W., and Matthews, S. G. (2010). Effect of glucocorticoids on regulation of placental multidrug resistance phosphoglycoprotein (P-gp) in the mouse. Placenta 31, 803–810.
| Effect of glucocorticoids on regulation of placental multidrug resistance phosphoglycoprotein (P-gp) in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtFWqt7bI&md5=f4b975f8fdc751bcace1523cc4cc0248CAS |
Petropoulos, S., Gibb, W., and Matthews, S.G. (2011). Glucocorticoid regulation of placental breast cancer resistance protein (Bcrp1) in the mouse. Reprod. Sci. 18, 631–639.
| Glucocorticoid regulation of placental breast cancer resistance protein (Bcrp1) in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXpsVKntr4%3D&md5=f5be9929882a9704e21f92bfc73b326fCAS |
Pickard, M. R., Sinha, A. K., Ogilvie, L. M., Leonard, A. J., Edwards, P. R., and Ekins, R. P. (1999). Maternal hypothyroxinemia influences glucose transporter expression in fetal brain and placenta. J. Endocrinol. 163, 385–394.
| Maternal hypothyroxinemia influences glucose transporter expression in fetal brain and placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXks1agtA%3D%3D&md5=8a8d8bbddcf6eb73f3be05e9b67674d3CAS |
Pickard, M. R., Leonard, A. J., Ogilvie, L. M., Edwards, P. R., Evans, I. M., Sinha, A. K., and Ekins, R. P. (2003). Maternal hypothyroidism in the rat influences placental and liver glycogen stores: fetal growth retardation near term is unrelated to maternal and placental glucose metabolic compromise. J. Endocrinol. 176, 247–255.
| Maternal hypothyroidism in the rat influences placental and liver glycogen stores: fetal growth retardation near term is unrelated to maternal and placental glucose metabolic compromise.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXhsVOkt7k%3D&md5=6a3961576f7d17a871ca667e15c9e856CAS |
Pringle, K. G., Kind, K. L., Thompson, J. G., and Roberts, C. T. (2007). Complex interactions between hypoxia inducible factors, insulin-like growth factor-II and oxygen in early murine trophoblasts. Placenta 28, 1147–1157.
| Complex interactions between hypoxia inducible factors, insulin-like growth factor-II and oxygen in early murine trophoblasts.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtF2qtrnI&md5=fe96c971f10638c1218cb4c4ec1509aeCAS |
Ravelli, G. P., Stein, Z. A., and Susser, M. W. (1976). Obesity in young men after famine exposure in utero and early infancy. N. Engl. J. Med. 295, 349–353.
| Obesity in young men after famine exposure in utero and early infancy.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaE283itVejsw%3D%3D&md5=f0bb77c3619b430617648b77caa35378CAS |
Rees, W. D., Hay, S. M., Brown, D. S., Antipatis, C., and Palmer, R. M. (2000). Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses. J. Nutr. 130, 1821–1826.
| 1:CAS:528:DC%2BD3cXks12itbo%3D&md5=4222ee56248b61da4d5dbe9a2ebe987fCAS |
Reid, G. J., Lane, R. H., Flozak, A. S., and Simmons, R. A. (1999). Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats. Am. J. Obstet. Gynecol. 180, 1017–1023.
| Placental expression of glucose transporter proteins 1 and 3 in growth-restricted fetal rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXivFeksb8%3D&md5=137dd3c3aec550c4575d6710a92c321aCAS |
Reynolds, L. P., Borowicz, P. P., Vonnahme, K. A., Johnson, M. L., Grazul-Bilska, A. T., Wallace, J. M., Caton, J. S., and Redmer, D. A. (2005). Animal models of placental angiogenesis. Placenta 26, 689–708.
| Animal models of placental angiogenesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFSmsbrJ&md5=2646f6ac47b3ce9f156bd65a5da99147CAS |
Reynolds, L. P., Caton, J. S., Redmer, D. A., Grazul-Bilska, A. T., Vonnahme, K. A., Borowicz, P. P., Luther, J. S., Wallace, J. M., Wu, G., and Spencer, T. E. (2006). Evidence for altered placental blood flow and vascularity in compromised pregnancies. J. Physiol. 572, 51–58.
| 1:CAS:528:DC%2BD28Xkt1GhtLk%3D&md5=dd57f8f7077999db398847cd6da762e2CAS |
Roberts, C. T., Sohlstrom, A., Kind, K. L., Earl, R. A., Khong, T. Y., Robinson, J. S., Owens, P. C., and Owens, J. A. (2001a). Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig. Placenta 22, 177–185.
| Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M3jsVWmug%3D%3D&md5=11013598f6c9b6072f2d3fd4c924c9fdCAS |
Roberts, C. T., Sohlstrom, A., Kind, K. L., Grant, P. A., Earl, R. A., Robinson, J. S., Khong, T. Y., Owens, P. C., and Owens, J. A. (2001b). Altered placental structure induced by maternal food restriction in guinea pigs: a role for circulating IGF-II and IGFBP-2 in the mother? Placenta 22, S77–82.
| Altered placental structure induced by maternal food restriction in guinea pigs: a role for circulating IGF-II and IGFBP-2 in the mother?Crossref | GoogleScholarGoogle Scholar |
Roos, S., Lagerlof, O., Wennergren, M., Powell, T. L., and Jansson, T. (2009a). Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. Am. J. Physiol. Cell Physiol. 297, C723–C731.
| Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXht1yktbbF&md5=80a393551545ccb60a693cb59f981f1bCAS |
Roos, S., Powell, T. L., and Jansson, T. (2009b). Placental mTOR links maternal nutrient availability to fetal growth. Biochem. Soc. Trans. 37, 295–298.
| Placental mTOR links maternal nutrient availability to fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXotVWktw%3D%3D&md5=5e31cdcc68f76d1c0cf32ac257067565CAS |
Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., and Jansson, T. (2011). Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology 152, 1119–1129.
| Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXktVGrtr0%3D&md5=68e7a0bb3697d3d93441a727014ba0cbCAS |
Rosso, P. (1977a). Maternal-fetal exchange during protein malnutrition in the rat. Placental transfer of alpha-amino isobutyric acid. J. Nutr. 107, 2002–2005.
| 1:CAS:528:DyaE1cXitV2ktQ%3D%3D&md5=758e37ba2b6bb657734393afc138a3e2CAS |
Rosso, P. (1977b). Maternal-fetal exchange during protein malnutrition in the rat. Placental transfer of glucose and a nonmetabolizable glucose analog. J. Nutr. 107, 20 006–20 010.
| 1:STN:280:DyaE1c%2FgslertQ%3D%3D&md5=1901e651aaf16835c4300dbd447900afCAS |
Rosso, P., and Kava, R. (1980). Effects of food restriction on cardiac ouput and blood flow to the uterus and placenta in the pregnant rat. J. Nutr. 110, 2350–2354.
| 1:STN:280:DyaL3M%2FntFGgsQ%3D%3D&md5=c5f4024a77d311285612cf373dc340d3CAS |
Rutland, C. S., Latunde-Dada, A. O., Thorpe, A., Plant, R., Langley-Evans, S., and Leach, L. (2007). Effect of gestational nutrition on vascular integrity in the murine placenta. Placenta 28, 734–742.
| Effect of gestational nutrition on vascular integrity in the murine placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmtlamurs%3D&md5=6230348c1208ab4d57fd0519f02f9345CAS |
Seckl, J. R., and Holmes, M. C. (2007). Mechanisms of Disease: glucocorticoids, their placental metabolism and fetal ‘programming’ of adult pathophysiology. Nat. Clin. Prac. Endocrionol. Metabol. 3, 479–488.
| 1:CAS:528:DC%2BD2sXlsFGrs78%3D&md5=48f76ddb5ec97d4156f9eae098af2b99CAS |
Senner, C. E., and Hemberger, M. (2010). Regulation of early trophoblast differentiation – lessons from the mouse. Placenta 31, 944–950.
| Regulation of early trophoblast differentiation – lessons from the mouse.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3cbhvFenuw%3D%3D&md5=626f4ae680fc58eee7b655532eb768ecCAS |
Serman, L., Vlahovic, M., Sijan, M., Bulic-Jakus, F., Serman, A., Sincic, N., Matijevic, R., Juric-Lekic, G., and Katusic, A. (2007). The impact of 5-azacytidine on placental weight, glycoprotein pattern and proliferating cell nuclear antigen expression in rat placenta. Placenta 28, 803–811.
| The impact of 5-azacytidine on placental weight, glycoprotein pattern and proliferating cell nuclear antigen expression in rat placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXotVGqt74%3D&md5=7d64daf1ae21c117dcc682349c27c92bCAS |
Sferruzzi-Perri, A. N., Owens, J., Pringle, K. G., Robinson, J. S., and Roberts, C. (2006). Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth. Endocrinology 147, 3344–3355.
| Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XmtlOrs70%3D&md5=6e45237e33b64dc6c932d337ee4f365bCAS |
Sferruzzi-Perri, A. N., Owens, J. A., Standen, P., Taylor, R. L., Heinemann, G. K., Robinson, J. S., and Roberts, C. T. (2007a). Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term. Am. J. Physiol. Endocrinol. Metab. 292, E668–E676.
| Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjsFeqsbs%3D&md5=bd0ba4afebb2c1f20a4da59652b36739CAS |
Sferruzzi-Perri, A. N., Owens, J. A., Standen, P., Taylor, R. L., Robinson, J. S., and Roberts, C. T. (2007b). Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation. Endocrinology 148, 4362–4370.
| Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXpslCnur4%3D&md5=1d721afb87b56fe383674ae716523593CAS |
Sferruzzi-Perri, A., Vaughan, O. R., Burton, G., and Fowden, A. (2009). Maternal diets high in sugar and fat impair labyrinthine development and amino acid transfer in the mouse placenta. Placenta 30, A8..
Sferruzzi-Perri, A. N., Owens, J. A., Pringle, K. G., and Roberts, C. T. (2011a). The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth. J. Physiol. 589, 7–20.
| The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXls1Ohtw%3D%3D&md5=dcbc504a6d31ff703fee5a381c03d6d9CAS |
Sferruzzi-Perri, A. N., Vaughan, O. R., Coan, P. M., Suciu, M. C., Darbyshire, R., Constancia, M., Burton, G. J., and Fowden, A. L. (2011b). Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice. Endocrinology 152, 3203–3212.
| Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice.Crossref | GoogleScholarGoogle Scholar |
Sibley, C. P., Coan, P. M., Ferguson-Smith, A. C., Dean, W., Hughes, J., Smith, P., Reik, W., Burton, G. J., Fowden, A. L., and Constancia, M. (2004). Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta. Proc. Natl Acad. Sci. USA 101, 8204–8208.
| Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXkslCitLo%3D&md5=6347e9a8edcdefc5781c83b776f2095fCAS |
Smith, J. T., and Waddell, B. J. (2003). Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids. Endocrinology 144, 3024–3030.
| Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXkvF2kt7s%3D&md5=8a1389903cbf6349c608746e78954a7aCAS |
Speirs, H. J., Seckl, J. R., and Brown, R. W. (2004). Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. J. Endocrinol. 181, 105–116.
| Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXjvVaqsrc%3D&md5=1483f6462806df9bbef72d4d88307416CAS |
Su, J.-M., Yang, B., Wang, Y.-S., Li, Y.-Y., Xiong, X.-R., Wang, L.-J., Guo, Z.-K., and Zhang, Y. (2011). Expression and methylation status of imprinted genes in placentas of deceased and live cloned transgenic calves. Theriogenology 75, 1346–1359.
| Expression and methylation status of imprinted genes in placentas of deceased and live cloned transgenic calves.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXjs12jt7o%3D&md5=f289851d9491bdae8aacabab01c49884CAS |
Sun, M., Kingdom, J., Baczyk, D., Lye, S. J., Matthews, S. G., and Gibb, W. (2006). Expression of the multidrug resistance P-glycoprotein (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation. Placenta 27, 602–609.
| Expression of the multidrug resistance P-glycoprotein (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XjvVagtr0%3D&md5=6de95c3c3a55e2177ecdf5ed2f5c6b32CAS |
Tanaka, S., Oda, M., Toyoshima, Y., Wakayama, T., Tanaka, M., Yoshida, N., Hattori, N., Ohgane, J., Yanagimachi, R., and Shiota, K. (2001). Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer. Biol. Reprod. 65, 1813–1821.
| Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXos1Kntrk%3D&md5=52b49f73c351559dfc96e8868745e9bfCAS |
Thompson, A. (2002). Spatial and temporal patterns of expression of 11-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in the murine placenta and uterus during late pregnancy. Biol. Reprod. 67, 1708–1718.
| Spatial and temporal patterns of expression of 11-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in the murine placenta and uterus during late pregnancy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XptVels7s%3D&md5=810951d41729de9d7d3f4dea3913b4eaCAS |
Vackova, Z., Vagnerova, K., Libra, A., Miksik, I., Pacha, J., and Staud, F. (2009). Dexamethasone and beta-methasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta. Reprod. Toxicol. 28, 46–51.
| Dexamethasone and beta-methasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXms1KmtLc%3D&md5=4c69ea06a17f80a5a4bd25a1cffb777aCAS |
Van Mieghem, T., van Bree, R., Van Herck, E., Deprest, J., and Verhaeghe, J. (2009). Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R1615–R1621.
| Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsValtrzO&md5=36cae41b6f915a587a7df1bb5659a209CAS |
Vaughan, O. R., Forhead, A. J., and Fowden, A. (2011a) Glucocorticoids and placental programming. In ‘The Placenta and Human Developmental Programming’. (Eds G. Burton, D. J. Barker, A. Moffett, K. Thornburg.) pp. 175–185. (Cambridge University Press: Cambridge, UK.)
Vaughan, O. R., Sferruzzi-Perri, A. N., and Fowden, A. L. (2011b). Maternal corticosterone (CORT) administration programs placental phenotype in mice. J. Dev. Origins of Health and Disease 2, 85..
von Versen-Höynck, F., Rajakumar, A., Parrott, M. S., and Powers, R. W. (2009). Leptin affects system A amino acid transport activity in the human placenta: evidence for STAT3 dependent mechanisms. Placenta 30, 361–367.
| Leptin affects system A amino acid transport activity in the human placenta: evidence for STAT3 dependent mechanisms.Crossref | GoogleScholarGoogle Scholar |
Wakefield, S. L., Lane, M., and Mitchell, M. (2011). Impaired mitochondrial function in the preimplantation embryo perturbs fetal and placental development in the mouse. Biol. Reprod. 84, 572–580.
| Impaired mitochondrial function in the preimplantation embryo perturbs fetal and placental development in the mouse.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXis1OmtL4%3D&md5=f945f510a22540d370759256d4a02f7fCAS |
Wakisaka-Saito, N., Kohla, T., Inoue, K., Ogonuki, N., Miki, H., Hikicki, T., Mizutani, E., Wakayama, T., Kaneko-Ishino, T., Ogura, A., and Ishino, F. (2006). Chorioallantoic placenta defects in cloned mice. Biochem. Biophys. Res. Commun. 349, 106–114.
| Chorioallantoic placenta defects in cloned mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XpsVKrs7o%3D&md5=2d3255270b7123069a3dbf3c345b7dd7CAS |
Watson, E. D., and Cross, J. C. (2005). Development of the structures and transport functions in the mouse placenta. Physiology (Bethesda) 20, 180–193.
| Development of the structures and transport functions in the mouse placenta.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXls1GgtrY%3D&md5=0ee801c2980bab586bbcf6deae9bbfc6CAS |
Wei, Y., Zhu, J., Liu, Z., Yang, C., Zhang, X., Xia, P., and Liu, Z. (2010). Aberrant expression and methylation status of outatively imprinted genes in placenta of cloned piglets. Cell Reprogram. 12, 213–222.
| 1:CAS:528:DC%2BC3cXlvVahtLg%3D&md5=edfb067aa27bd19a9e48225f642fa84dCAS |
Wilson, M. E., Biensen, N. J., Youngs, C. R., and Ford, S. P. (1998). Development of Meishan and Yorkshire littermate conceptuses in either a Meishan or Yorkshire uterine environment to day 90 of gestation and to term. Biol. Reprod. 58, 905–910.
| Development of Meishan and Yorkshire littermate conceptuses in either a Meishan or Yorkshire uterine environment to day 90 of gestation and to term.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXit1Khsbk%3D&md5=334ee1f7f876b2e0cc0cfd775d90e5a1CAS |
Wlodek, M. E., Westcott, K. T., O’Dowd, R., Serruto, A., Wassef, L., Moritz, K. M., and Moseley, J. M. (2005). Uteroplacental restriction in the rat impairs fetal growth in association with alterations in placental growth factors including PTHrP. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1620–R1627.
| Uteroplacental restriction in the rat impairs fetal growth in association with alterations in placental growth factors including PTHrP.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXlsVyms7s%3D&md5=f8dfe160cd7586cf3071dfd1bcee52faCAS |
Wyrwoll, C. S., Mark, P. J., and Waddell, B. J. (2007). Developmental programming of renal glucocorticoid sensitivity and the renin–angiotensin system. Hypertension 50, 579–584.
| Developmental programming of renal glucocorticoid sensitivity and the renin–angiotensin system.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXptlyktbs%3D&md5=bcf9478a2f721afd78485a29d9e906bcCAS |
Wyrwoll, C. S., Seckl, J. R., and Holmes, M. C. (2009). Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice. Endocrinology 150, 1287–1293.
| Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXisV2gtL4%3D&md5=b3e08d033676dcd2c78661a6b2a4bf66CAS |
Yamashita, H., Shao, J., Ishizuka, T., Klepcyk, P. J., Muhlenkamp, P., Qiao, L., Hoggard, N., and Friedman, J. E. (2001). Leptin administration prevents spontaneous gestational diabetes in heterozygous Lepr(db/+) mice: effects on placental leptin and fetal growth. Endocrinology 142, 2888–2897.
| Leptin administration prevents spontaneous gestational diabetes in heterozygous Lepr(db/+) mice: effects on placental leptin and fetal growth.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXkslelsLg%3D&md5=1770866bee9867076c8fb68674c88a8dCAS |
Zhang, S., Kubota, C., Yang, L., Zhang, Y., Page, R., O’Neill, M., Yang, X., and Tian, X. C. (2004). Genomic imprinting of H19 in naturally produced and cloned cattle. Biol. Reprod. 71, 1540–1544.
| Genomic imprinting of H19 in naturally produced and cloned cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXpt1yisLY%3D&md5=b539bd5c41246116f68fa91886eb2c15CAS |
Zhang, Y., Cui, Y., Zhou, Z., Sha, J., Li, Y., and Liu, J. (2010). Altered global gene expression of human placentae subjected to assisted reproductive technology treatments. Placenta 31, 251–258.
| Altered global gene expression of human placentae subjected to assisted reproductive technology treatments.Crossref | GoogleScholarGoogle Scholar |
Zhou, J., and Bondy, C. A. (1993). Placental glucose transporter gene expression and metabolism in the rat. J. Clin. Invest. 91, 845–852.
| Placental glucose transporter gene expression and metabolism in the rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3sXitV2qsbo%3D&md5=fb632923d5a23f94c9f5cd0647bf6a20CAS |
