Acute vancomycin-resistant enterococcal bacteraemia outbreak analysis in haematology patients: a case-control study
Ian Gassiep A B F , Mark Armstrong A B , Zoe Van Havre E , Sanmarie Schlebusch B C , Joseph McCormack A B C and Paul Griffin A B C D
+ Author Affiliations
- Author Affiliations
A Department of Infectious Diseases, Mater Health Services and Mater Medical Research Institute, South Brisbane, Qld 4101, Australia.
B School of Medicine, University of Queensland, Mater Hospital Campus, South Brisbane, Qld 4101, Australia.
C Department of Microbiology Mater Health Services and Mater Medical Research Institute, South Brisbane, Qld 4101, Australia.
D The QIMR Berghofer Medical Research Institute, Royal Brisbane and Women’s Hospital, Brisbane, Qld 4006, Australia.
E Queensland University of Technology, Brisbane, Qld 4000, Australia.
F Corresponding author. Email: ian.gassiep@gmail.com
Healthcare Infection 20(4) 115-123 https://doi.org/10.1071/HI15013
Submitted: 27 June 2015 Accepted: 17 August 2015 Published: 7 September 2015
Abstract
Introduction: We report a retrospective case-control series of a vancomycin-resistant Enterococcus faecium (VRE) bacteraemia outbreak at a tertiary metropolitan hospital in Queensland, Australia. The outbreak occurred on a haematology ward between 8 and 14 February 2014, 6 weeks after a ward relocation. The aim was to determine risk factors related to progression from colonisation with VRE to bacteraemia.
Methods: The cases were patients with haematological malignancy and proven catheter-related VRE bacteraemia. Matched controls were selected from the same ward with similar underlying haematological diagnoses and proven gastrointestinal VRE colonisation without invasive infection.
Results: This study suggests that female sex, recent administration of total parenteral nutrition, right-sided catheter placement with odds ratios (OR) 1.99, gastrointestinal disruption (OR: 1.91), and dexamethasone administration (OR: 2.37) are potential risk factors for progression from colonisation to infection. Notably, given the small sample size, the 95% confidence intervals are wide ranging from 0.02 to 222.
Conclusion: While progression from colonisation with VRE to invasive disease is likely to be a complex multifactorial process, the results of this study suggest certain clinical variables that warrant enhanced vigilance to reduce this occurrence. Interestingly, recent relocation of the haematology ward may play a significant role in this outbreak. This study highlights the importance of good infection control practice and the need for additional studies to further delineate risk factors for invasive VRE infection.
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