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Healthcare Infection Healthcare Infection Society
Official Journal of the Australasian College for Infection Prevention and Control
REVIEW (Open Access)

Urinary tract infection in long-term care facilities

Lindsay E. Nicolle
+ Author Affiliations
- Author Affiliations

Department of Internal Medicine and Medical Microbiology, University of Manitoba, Winnipeg, MB R3A 1R9, Canada. Email: lnicolle@hsc.mb.ca

Healthcare Infection 19(1) 4-12 https://doi.org/10.1071/HI13043
Submitted: 13 November 2013  Accepted: 28 November 2013   Published: 17 December 2013

Journal Compilation © Australasian College for Infection Prevention and Control 2014

Abstract

Introduction: Asymptomatic bacteriuria and pyuria are pervasive in the long-term care population. Optimal management of urinary infection for residents of long-term care facilities requires knowledge of the unique features of the infection in this setting, together with critical evaluation of each episode of potential urinary infection in the individual resident.

Method: A non-structured review of current knowledge and recommendations relevant to urinary infection in long-term care facilities.

Results: Urinary infection is the second most common infection occurring in long-term care facility residents. For residents without chronic indwelling catheters, acute, localising, genitourinary symptoms should be present to support a clinical diagnosis of symptomatic infection. Inappropriate antimicrobial use for urinary tract infection, particularly treatment of asymptomatic bacteriuria and prophylaxis of urinary infection, is a consistent observation in reviews of antimicrobial use in these facilities. Management approaches to improve treatment include observation and reassessment when symptoms are questionable or the diagnosis is unclear, limiting the use of chronic indwelling catheters, and early identification of complications, such as obstruction, of indwelling catheters.

Conclusions: Clinical diagnostic imprecision and a high prevalence of asymptomatic bacteriuria means these infections are overdiagnosed and overtreated, leading to adverse events from excess antimicrobial use. Antimicrobial stewardship programs to improve antimicrobial use for this indication need to be developed in long-term care facilities.


References

[1]  Stevenson KB, Moore J, Colwell H, Sleeper B. Standardized infection surveillance in long-term care: interfacility comparisons from a regional cohort of facilities. Infect Control Hosp Epidemiol 2005; 26 231–8.
Standardized infection surveillance in long-term care: interfacility comparisons from a regional cohort of facilities.Crossref | GoogleScholarGoogle Scholar | 15796273PubMed |

[2]  Dwyer LL, Harris-Kojetin LD, Valverde RH, Frazier JM, Simon AE, Stone ND, et al Infections in long term care populations in the United Sates. J Am Geriatr Soc 2013; 61 341–9.
Infections in long term care populations in the United Sates.Crossref | GoogleScholarGoogle Scholar |

[3]  Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, et al IDSA guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 2005; 40 643–54.
IDSA guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults.Crossref | GoogleScholarGoogle Scholar | 15714408PubMed |

[4]  Nicolle LE. Urinary tract infections in the elderly. Clin Geriatr Med 2009; 25 423–36.
Urinary tract infections in the elderly.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1MnjsFCqsw%3D%3D&md5=2ba161edaa474a7b76447830946bd5c6CAS | 19765490PubMed |

[5]  van Buul LW, van der Steen JT, Veenhuizen RB, Achterberg WP, Schellevis FG, Essink RT, et al Antibiotic use and resistance in long term care facilities. J Am Med Dir Assoc 2012; 568 e1–13.

[6]  Nicolle LE. Catheter related urinary tract infection: Practical management in the elderly. Drugs Aging 2013; In press
Catheter related urinary tract infection: Practical management in the elderly.Crossref | GoogleScholarGoogle Scholar | 24288197PubMed |

[7]  Blix HS, Bergman J, Schjott J. How are antibacterials used in nursing homes? Results from a point prevalence prescription study in 44 Norwegian nursing homes. Pharmacoepidemiol Drug Saf 2010; 19 1025–30.
How are antibacterials used in nursing homes? Results from a point prevalence prescription study in 44 Norwegian nursing homes.Crossref | GoogleScholarGoogle Scholar | 20712026PubMed |

[8]  Hajdu A, Eriksen HM, Sorknes NK, Hauge SH, Loewer HL, Iversen BG, et al Evolution of the national surveillance system for point-prevalence of healthcare-associated infections in hospitals and in long-term care facilities for elderly in Norway, 2002–2008. BMC Public Health 2011; 11 923–34.
Evolution of the national surveillance system for point-prevalence of healthcare-associated infections in hospitals and in long-term care facilities for elderly in Norway, 2002–2008.Crossref | GoogleScholarGoogle Scholar | 22165849PubMed |

[9]  Chami K, Gavazzi G, Carrat F, de Wazieres B, Lejeune B, Piette F, et al Burden of infections among 44,869 elderly in nursing homes: a cross-sectional cluster nationwide survey. J Hosp Infect 2011; 79 254–9.
Burden of infections among 44,869 elderly in nursing homes: a cross-sectional cluster nationwide survey.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3MblvFCqug%3D%3D&md5=e267a71f561f3530f0760961d0266f10CAS | 21899920PubMed |

[10]  Eikelenboom-Boskamp A, Cox-Claessens JHM, Boom-Poels PGM, Drabbe MIJ, Koopmans RTCM, Voss A. Three year prevalence of healthcare-associated infections in Dutch nursing homes. J Hosp Infect 2011; 78 59–62.
Three year prevalence of healthcare-associated infections in Dutch nursing homes.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3MvktFShuw%3D%3D&md5=b09525921d2bf5cf49b90239bcfd830bCAS | 21435737PubMed |

[11]  Tsan L, Davis C, Langberg R, Hojlo C, Pierce J, Miller M, et al Prevalence of nursing home-associated infections in the Department of Veterans Affairs nursing home care units. Am J Infect Control 2008; 36 173–9.
Prevalence of nursing home-associated infections in the Department of Veterans Affairs nursing home care units.Crossref | GoogleScholarGoogle Scholar | 18371512PubMed |

[12]  Engelhart ST, Hanses-Derendorf L, Exner J, Kramer MH. Prospective surveillance for healthcare-associated infections in German nursing home residents. J Hosp Infect 2005; 60 46–50.
Prospective surveillance for healthcare-associated infections in German nursing home residents.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2M7ptV2ksQ%3D%3D&md5=52dff1aa81375ff173d0fdce4fac3c56CAS | 15823656PubMed |

[13]  Pettersson E, Vernby A, Molstad S, Lundborg CS. Infections and antibiotic prescribing in Swedish nursing homes: a cross-sectional study. Scand J Infect Dis 2008; 40 393–8.
Infections and antibiotic prescribing in Swedish nursing homes: a cross-sectional study.Crossref | GoogleScholarGoogle Scholar | 18418800PubMed |

[14]  Wang L, Lansing B, Symons K, Flannery EL, Fisch J, Cherian K, et al Infection rate and colonization with antibiotic-resistant organisms in skilled nursing facility residents with indwelling devices. Eur J Clin Microbiol Infect Dis 2012; 31 1797–804.
Infection rate and colonization with antibiotic-resistant organisms in skilled nursing facility residents with indwelling devices.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC38vhtFajuw%3D%3D&md5=8d26c84518191a69401f53cfc0d9f360CAS | 22274858PubMed |

[15]  Wójkowska-Mach J, Gryglewska B, Czekaj J, Adamski P, Grodzicki T, Heczko PB. Infection control: point prevalence study versus incidence study in Polish long-term care facilities in 2009–2010. Infection 2013; 41 1–8.
Infection control: point prevalence study versus incidence study in Polish long-term care facilities in 2009–2010.Crossref | GoogleScholarGoogle Scholar | 23086684PubMed |

[16]  Warren JW, Damron D, Tenney JH, Hoopes JM, Deforge B, Muncie HL. Fever, bacteremia, and death as complications of bacteriuria in women with long-term urethral catheters. J Infect Dis 1987; 155 1151–8.
Fever, bacteremia, and death as complications of bacteriuria in women with long-term urethral catheters.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL2s7ps1GlsQ%3D%3D&md5=b7d915da47aa1af42d26edde77192269CAS | 3572035PubMed |

[17]  Mylotte JM, Tayara A, Goodnough S. Epidemiology of bloodstream infection in nursing home residents: evaluation in a large cohort from multiple homes. Clin Infect Dis 2002; 35 1484–90.
Epidemiology of bloodstream infection in nursing home residents: evaluation in a large cohort from multiple homes.Crossref | GoogleScholarGoogle Scholar | 12471567PubMed |

[18]  Stickler DJ, Feneley RCL. The encrustation and blockage of long-term indwelling bladder catheters: a way forward in prevalence and control. Spinal Cord 2010; 48 784–90.
The encrustation and blockage of long-term indwelling bladder catheters: a way forward in prevalence and control.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3cbktlGqtA%3D%3D&md5=84486622d9fbf03a383dbd42c7e7e269CAS | 20368711PubMed |

[19]  Rogers MAM, Fries BE, Kaufman SR, Mody L. McMahon LF Jr, Saint S. Mobility and other predictors of hospitalization for urinary tract infection: a retrospective cohort study. BMC Geriatr 2008; 8 31–9.
McMahon LF Jr, Saint S. Mobility and other predictors of hospitalization for urinary tract infection: a retrospective cohort study.Crossref | GoogleScholarGoogle Scholar |

[20]  Omli R, Skotnes LH, Mykletun A, Bakke AM, Kuhry E. Residual urine as a risk factor for lower urinary tract infection: A 1-year follow-up study in nursing homes. J Am Geriatr Soc 2008; 56 871–4.
Residual urine as a risk factor for lower urinary tract infection: A 1-year follow-up study in nursing homes.Crossref | GoogleScholarGoogle Scholar | 18331294PubMed |

[21]  Ouslander JG, Greengold B, Chen S. External catheter use and urinary tract infection among incontinent male nursing home patients. J Am Geriatr Soc 1987; 35 1063–70.
| 1:STN:280:DyaL1c%2FmtVajtA%3D%3D&md5=f8a044e9fafd3ca64473dcef3e74447cCAS | 3680838PubMed |

[22]  Büla CJ, Ghilardi G, Wietlisbach V, Petignat C, Francioli P. Infections and functional impairment in nursing home residents: a reciprocal relationship. J Am Geriatr Soc 2004; 52 700–6.
Infections and functional impairment in nursing home residents: a reciprocal relationship.Crossref | GoogleScholarGoogle Scholar | 15086648PubMed |

[23]  Das R, Towle V, Van Ness PH, Juthani-Mehta M. Adverse outcomes in nursing home residents with increased episodes of observed bacteriuria. Infect Control Hosp Epidemiol 2011; 32 84–6.
Adverse outcomes in nursing home residents with increased episodes of observed bacteriuria.Crossref | GoogleScholarGoogle Scholar | 21091203PubMed |

[24]  Rotjanapan P, Dosa D, Thomas KS. Potentially inappropriate treatment of urinary tract infections in two Rhode Island nursing homes. Arch Intern Med 2011; 171 438–43.
Potentially inappropriate treatment of urinary tract infections in two Rhode Island nursing homes.Crossref | GoogleScholarGoogle Scholar | 21403040PubMed |

[25]  Lautenbach E, Marsicano R, Tolomeo P, Heard M, Serrano S, Stieritz DD. Epidemiology of antimicrobial resistance among gram-negative organisms recovered from patients in a multistate network of long-term care facilities. Infect Control Hosp Epidemiol 2009; 30 790–3.
Epidemiology of antimicrobial resistance among gram-negative organisms recovered from patients in a multistate network of long-term care facilities.Crossref | GoogleScholarGoogle Scholar | 19566445PubMed |

[26]  Stuart RL, Kotsanas D, Webb B, Vandergraaf S, Gillespie EE, Hogg GG, et al Prevalence of antimicrobial-resistant organisms in residential aged care facilities. Med J Aust 2011; 195 530–3.
Prevalence of antimicrobial-resistant organisms in residential aged care facilities.Crossref | GoogleScholarGoogle Scholar | 22060088PubMed |

[27]  Rooney PJ, O’Leary MC, Loughrey AC, Calmont M, Smyth B, Donaghy P, et al Nursing homes as a reservoir of extended-spectrum β-lactamase (ESBL) producing ciprofloxacin-resistant Escherichia coli. J Antimicrob Chemother 2009; 64 635–41.
Nursing homes as a reservoir of extended-spectrum β-lactamase (ESBL) producing ciprofloxacin-resistant Escherichia coli.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtVWju7jN&md5=10d1c2e61d070f2814c42dddcefb033bCAS | 19549667PubMed |

[28]  Ben-David D, Marsawa S, Navon-Venezie S, Mishali H, Fridental I, Rubinovitch B, et al Carbapenem-resistant Klebsiella pneumoniae in post-acute-care facilities in Israel. Infect Control Hosp Epidemiol 2011; 32 845–53.
Carbapenem-resistant Klebsiella pneumoniae in post-acute-care facilities in Israel.Crossref | GoogleScholarGoogle Scholar | 21828964PubMed |

[29]  Marquez P, Terashita D, Dassey D, Mascola L. Population-based incidence of carbapenem-resistant Klebsiella pneumoniae along the continuum of care, Los Angeles County. Infect Control Hosp Epidemiol 2013; 34 144–50.
Population-based incidence of carbapenem-resistant Klebsiella pneumoniae along the continuum of care, Los Angeles County.Crossref | GoogleScholarGoogle Scholar | 23295560PubMed |

[30]  Loeb MB, Craven S, McGeer AJ, Simor AE, Bradley SF, Low DE, et al Risk factors for resistance to antimicrobial agents among nursing home residents. Am J Epidemiol 2003; 157 40–7.
Risk factors for resistance to antimicrobial agents among nursing home residents.Crossref | GoogleScholarGoogle Scholar | 12505889PubMed |

[31]  Bianco L, Perrelli E, Towle J, Van Ness PH, Juthani-Mehta M. Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. J Am Geriatr Soc 2012; 60 1180–1.
Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents.Crossref | GoogleScholarGoogle Scholar | 22690994PubMed |

[32]  High KP, Bradley SF, Gravenstein S, Mehr DR, Quaglarello VJ, Richards C, et al Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities. Clin Infect Dis 2009; 48 149–71.
Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities.Crossref | GoogleScholarGoogle Scholar | 19072244PubMed |

[33]  Loeb M, Bentley DW, Bradley S, Crossley K, Garibaldi R, Gantz N, et al Development of minimum criteria for the initiation of antibiotics in residents of long term care facilities: results of a consensus conference. Infect Control Hosp Epidemiol 2001; 22 120–4.
Development of minimum criteria for the initiation of antibiotics in residents of long term care facilities: results of a consensus conference.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M3gsVeltA%3D%3D&md5=1081726f777f4d576731da3df3a799b1CAS | 11232875PubMed |

[34]  Stone ND, Ashraf MS, Calder J, Crnich CJ, Crossley K, Drinka PJ, et al Surveillance definitions of infections in long-term care facilities: revisiting the McGeer Criteria. Infect Control Hosp Epidemiol 2012; 33 965–77.
Surveillance definitions of infections in long-term care facilities: revisiting the McGeer Criteria.Crossref | GoogleScholarGoogle Scholar | 22961014PubMed |

[35]  Juthani-Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical features to identify UTI in nursing home residents: a cohort study. J Am Geriatr Soc 2009; 57 963–70.
Clinical features to identify UTI in nursing home residents: a cohort study.Crossref | GoogleScholarGoogle Scholar | 19490243PubMed |

[36]  Woodford HJ, George J. Diagnosis and management of urinary tract infection in hospitalized older people. J Am Geriatr Soc 2009; 57 107–14.
Diagnosis and management of urinary tract infection in hospitalized older people.Crossref | GoogleScholarGoogle Scholar | 19054190PubMed |

[37]  Nicolle LE. Symptomatic urinary tract infections in nursing home residents. J Am Geriatr Soc 2009; 57 1113–4.
Symptomatic urinary tract infections in nursing home residents.Crossref | GoogleScholarGoogle Scholar | 19490245PubMed |

[38]  Sundvall P-D, Ulleryd P, Gunnarson RK. Urine culture doubtful in determining etiology of diffuse symptoms among elderly individuals: A cross-sectional study of 32 nursing homes. BMC Fam Pract 2011; 12 36
Urine culture doubtful in determining etiology of diffuse symptoms among elderly individuals: A cross-sectional study of 32 nursing homes.Crossref | GoogleScholarGoogle Scholar | 21592413PubMed |

[39]  Rowe T, Towle V, Van Ness PH, Juthani-Mehta M. Lack of positive association between falls and bacteriuria plus pyuria in older nursing home residents. J Am Geriatr Soc 2013; 61 653–4.
Lack of positive association between falls and bacteriuria plus pyuria in older nursing home residents.Crossref | GoogleScholarGoogle Scholar | 23581923PubMed |

[40]  Raz R, Schiller D, Nicolle LE. Chronic indwelling catheter replacement prior to antimicrobial therapy for symptomatic urinary infection. J Urol 2000; 164 1254–8.
Chronic indwelling catheter replacement prior to antimicrobial therapy for symptomatic urinary infection.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3cvksV2nsA%3D%3D&md5=0d08ba39b2bbeb5e763ca6785178120aCAS | 10992375PubMed |

[41]  Loeb M, Brazil K, Lohfeld L, McGeer A, Simor A, Stevenson K, et al Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomized controlled trial. BMJ 2005; 331 669
Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomized controlled trial.Crossref | GoogleScholarGoogle Scholar | 16150741PubMed |

[42]  Olsho LE, Bertrand RM, Edwards AS, Hadden LS, Morefield GB, Hurd D, et al Dose adherence to the Loeb minimum criteria reduce antibiotic prescribing rates in nursing homes? J Am Dir Assoc 2013; 14 309

[43]  D’Agata E, Loeb MB, Mitchell SL. Challenges in assessing nursing home residents with advanced dementia for suspected urinary tract infections. J Am Geriatr Soc 2013; 61 62–6.
Challenges in assessing nursing home residents with advanced dementia for suspected urinary tract infections.Crossref | GoogleScholarGoogle Scholar | 23311553PubMed |

[44]  Gomolin IH, Siami PF, Reuning-Scherer J, Haverstock MS, Heyd A. Efficacy and safety of ciprofloxacin oral suspension versus trimethoprim/sulfamethoxazole or suspension for treatment of older women with acute urinary tract infection. J Am Geriatr Soc 2001; 49 1606–13.
Efficacy and safety of ciprofloxacin oral suspension versus trimethoprim/sulfamethoxazole or suspension for treatment of older women with acute urinary tract infection.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD387htVGntA%3D%3D&md5=adb83f396e6d82122c24c5fa90ca8efbCAS | 11843992PubMed |

[45]  Vogel T, Verreault R, Gourdeau M, Morin H, Grenier-Gosselin L, Rochette L. Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older women: a double-blind randomized trial. CMAJ 2004; 170 469–73.
| 14970093PubMed |

[46]  Blix HS, Bergman J, Schjott J. How are antibacterials used in nursing homes? Results from a point-prevalence prescription study in 44 Norwegian nursing homes. Pharmacoepidemiol Drug Saf 2010; 19 1025–30.
How are antibacterials used in nursing homes? Results from a point-prevalence prescription study in 44 Norwegian nursing homes.Crossref | GoogleScholarGoogle Scholar | 20712026PubMed |

[47]  Cotter M, Donlon S, Roche F, Byrne H, Fitzpatrick F. Healthcare-associated infection in Irish long-term care facilities: results from the First National Prevalence Study. J Hosp Infect 2012; 80 212–6.
Healthcare-associated infection in Irish long-term care facilities: results from the First National Prevalence Study.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC383ks1OgtA%3D%3D&md5=66f153145af88fa92a7c50e3f03c059bCAS | 22305100PubMed |

[48]  Broex E, Catry B, Latour K, Mertens K, Vankerckhoven V, Muller A, et al Parenteral versus oral administration of systemic antimicrobials in European nursing homes: a point prevalence survey. Drugs Aging 2011; 28 809–18.
Parenteral versus oral administration of systemic antimicrobials in European nursing homes: a point prevalence survey.Crossref | GoogleScholarGoogle Scholar | 21970308PubMed |

[49]  Daneman N, Gruneir A, Newman A, Fischer HD, Bronskill SE, Rochan PA, et al Antibiotic use in long-term care facilities. J Antimicrob Chemother 2011; 66 2856–63.
Antibiotic use in long-term care facilities.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFSksbnP&md5=3c5eefdda4b01375d7e6a86132a71b7eCAS | 21954456PubMed |

[50]  Nicolle LE, AMMI-Canada Guidelines Committee Complicated urinary tract infection in adults. Can J Infect Dis Med Microbiol 2005; 16 349–60.
| 1:STN:280:DC%2BC3Mnns1ygsg%3D%3D&md5=b1cd2740f8fe32b6561deed7d237ddebCAS | 18159518PubMed |

[51]  Pettersson E, Vernby A, Molstad S, Lundborg CS. Can a multifaceted educational intervention targeting both nurses and physicians change the prescribing of antibiotics in nursing home residents? A cluster randomized trial. J Antimicrob Chemother 2011; 66 2659–66.
Can a multifaceted educational intervention targeting both nurses and physicians change the prescribing of antibiotics in nursing home residents? A cluster randomized trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtlaqtbfI&md5=a23b6374251b986df059948accec1061CAS | 21893568PubMed |

[52]  Zabarsky TF, Sethi AK, Donskey CJ. Sustained reduction in inappropriate treatment of asymptomatic bacteriuria in a long term care facility through an educational intervention. Am J Infect Control 2008; 36 476–80.
Sustained reduction in inappropriate treatment of asymptomatic bacteriuria in a long term care facility through an educational intervention.Crossref | GoogleScholarGoogle Scholar | 18786450PubMed |

[53]  Rummukainen ML, Jakobsson A, Matsinen M, Jarvenpaa S, Nissinen A, Karppi P, et al Reduction in inappropriate prevention of urinary tract infections in long-term care facilities. Am J Infect Control 2012; 40 711–4.
Reduction in inappropriate prevention of urinary tract infections in long-term care facilities.Crossref | GoogleScholarGoogle Scholar | 22297240PubMed |