Natural history of rectal colonisation with extended-spectrum beta-lactamase producing Enterobacteriaceae: a retrospective review with up to 6 years of follow-up
J. T. Freeman A B , S. Gormack A , M. N. De Almeida A and S. A. Roberts A
+ Author Affiliations
- Author Affiliations
A Department of Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand.
B Corresponding author. Email: JoshuaF@adhb.govt.nz
Healthcare Infection 18(4) 152-155 https://doi.org/10.1071/HI13013
Submitted: 19 March 2013 Accepted: 13 August 2013 Published: 24 September 2013
Abstract
Patients colonised with extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) pose a risk to other hospitalised patients and additional measures such as contact precautions are often used. For patients clearing colonisation, however, such measures are unjustified. We reviewed data from a large-scale active surveillance program for ESBL-E to describe the natural history of colonisation. Of 124 colonised patients with sequential rectal swabs, 32 (25.8%) cleared colonisation. Kaplan–Meier analysis suggested that 75% of patients remained colonised at 1 year and that the median duration of colonisation was ~3 years. Improved understanding of the natural history of ESBL-E colonisation will allow more rational approaches to managing previously colonised patients.
Additional keywords: duration of colonisation, extended-spectrum beta-lactamase, natural history of colonisation.
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