Synthesis and Antibacterial Activity of Some 'Bisquinolones'

Abstract

Ten ' bisquinolones' were prepared by joining two molecules of norfloxacin, or 1,8-naphthyridine and benzo [c][1,8] naphthyridine derivatives, with various aliphatic linkers. These were tested against 17 bacteria strains but none showed more than slight activity (MIC ≥ 10 mg/l). However, a 'monoquinolone' derived from benzo [c][1,8] naphthyridine showed greater activity than norfloxacin against a strain of Acinetobacter.