Synthesis of a Phosphinic Acid Transition State Analog Inhibitor of Dihydroorotase
Y Cao, RI Christopherson, JA Elix and KL Gaul
Australian Journal of Chemistry
47(5) 903 - 911
Published: 1994
Abstract
The synthesis of the phosphinic acid 4-hydroxy-6-oxo-1,4-azaphosphinane-2-carboxylic acid 4-oxide (11) is described. The phosphinic acid (11) was designed as a transition state analogue inhibitor of dihydroorotase.
https://doi.org/10.1071/CH9940903
© CSIRO 1994
