Potential Antimalarials. XVII. Di- and Mono-Mannich Bases of 2(and 4)-[2(and 8)-Trifluoromethylquinolin-4-ylamino]phenol
GB Barlin, TMT Nguyen, B Kotecka and KH Rieckmann
Australian Journal of Chemistry
46(1) 21 - 29
Published: 1993
Abstract
Di- and mono-Mannich base derivatives of 2(and 4)-[2(and 8)-trifluoromethylquinolin-4-ylamino]phenols have been prepared for comparison with the 7-trifluoromethyl isomers in tests for antimalarial activity. The order of activity in in vitro tests against the FC-27 ( chloroquine -sensitive) strain of Plasmodium falciparum was 7-CF3 >> 8-CF3 > 2-CF3.
https://doi.org/10.1071/CH9930021
© CSIRO 1993
