Semisyntheses, X-Ray Crystal Structures and Tubulin-Binding Properties of 7-Oxodeacetamidocolchicine and 7-Oxodeacetamidoisocolchicine
MG Banwell, SC Peters, RJ Greenwood, MF Mackay, E Hamel and CM Lin
Australian Journal of Chemistry
45(10) 1577 - 1588
Published: 1992
Abstract
Commercially available (–)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3). The X-ray structures and tubulin-binding properties of these title ketones are described.
https://doi.org/10.1071/CH9921577
© CSIRO 1992
