Phenolic Analogs of Amino Carboxylic Acid Ligands for ^99mTc. 4. N-(2-Hydroxybenzyl)glycines (hbg)

Abstract

Ten tridentate ligands , N-(2-hydroxybenzyl) glycines ( hbg ) (5), were prepared by the Mannich reaction of a phenol with formaldehyde and glycine and/or by the reduction of the Schiff base of a substituted salicylaldehyde and glycine. In three instances the bis compounds (6b,c,i) were also formed by the first method.