Free Standard AU & NZ Shipping For All Book Orders Over $80!
Register      Login
Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Synthesis of Substituted (+)-Bicuculline Derivatives Through Chloromethylation

RD Allan and C Apostopoulos

Australian Journal of Chemistry 43(7) 1259 - 1268
Published: 1990

Abstract

Treatment of the phthalide isoquinoline alkaloid (+)- bicuculline with paraformaldehyde and hydrochloric acid leads to the chloromethyl derivative (4) which can be further substituted with ammonia or piperazine . In reactions to study methods of linking bicuculline to macromolecules or to photolabile groups, the amino product (7a) has been further functionalized by the formation of amide linkages with succinic anhydride and 4-aminobenzoic acid.

https://doi.org/10.1071/CH9901259

© CSIRO 1990

Committee on Publication Ethics


Export Citation Get Permission

View Dimensions