Potential Antimalarials. X. Di-Mannich Bases of 4-(7'-Trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and N-(4'-Diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine
GB Barlin and C Jiravinyu
Australian Journal of Chemistry
43(7) 1175 - 1181
Published: 1990
Abstract
The syntheses of some di-Mannich bases derived from 4-(7′-trifluoromethyl-1′,5′-naphthyridin-4′-ylamino) phenol and of N-(4′-diethylamino-11′-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine from 3-chloro-5-trifluoromethylpyridine via4-chloro-7- trifluoromethyl-1,5-naphthyridine are described.
In tests in vitro against the FCQ-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues.
https://doi.org/10.1071/CH9901175
© CSIRO 1990