Epoxy Lipids From the Australian Epiphytic Brown Alga Notheia anomala

Abstract

A detailed reinvestigation of the chemistry of Notheia anomala has resulted in the isolation of the known C₁₉ lipid (1) together with 13 new C₁₉ lipids (2), (3), (3a,b,c) (4), (4a,b,c) (8), (10),(13) and (14), one new C₂₁ lipid (15) and two known C₂₁ lipids, (17) and (18), and a new C₁₇ lipid (19). The structures of these metabolites were established by spectroscopic analysis together with chemical derivatization and degradation. Absolute stereochemistries were determined by chemical and biosynthetic correlation to (1). A common biosynthetic pathway is proposed for all the oxygenated lipids from N. Anomala.