3,4,5,6,7,8-Hexahydro-1,7-benzodiazecin-2(1H)-one from Extracts of Mackinlaya Species

Abstract

A minor base from Mackinlaya macrosciadia (F. Muell ) F. Muell has been shown to be 3,4,5,6,7,8-hexahydro-1,7-benzodiazecin-2(1H)-one. This compound is formed in low yield from decomposition of 6,7,8,9- tetrahydro-11H-pyrido[2,1-b]quinazoline, the major base, on storage, and it is conveniently prepared by hydrolysis of the major base in water.