Formation of Thioamide Derivatives from Reactions of Isothiocyanates with Oxazol-2-amines

Abstract

4-Substituted oxazol-2-amines react with isothiocyanates to give products having a thioamide function at C5. The reaction is considered to be an electrophilic process in competition with the usual reaction of the amino group with the isothiocyanate . The nature of the isothiocyanate and the type of substituent at C4 affect the amount of the thioamide product formed. Some chemical properties of the thioamides are also investigated.