Application of the Elbs persulfate oxidation to the preparation of 5-hydroxypyrimidines

Abstract

The use of potassium persulfate in cold sodium hydroxide solution has been shown to give the pyrimidin-5-yl hydrogen sulfates in cases where the pyrimidine has at least two electron-releasing groups in the 2,4 or 6 positions. However, the reaction has been unsuccessful in a number of cases. The pyrimidin-5-yl hydrogen sulfates are hydrolysed to the corresponding 5-hydroxypyrimidines by hydrochloric acid.