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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Synthesis of analogues of GABA. X. The bicyclic β-diketone Octahydro-1H-2-pyrindine-5,7-dione

RD Allan and J Fong

Australian Journal of Chemistry 36(6) 1221 - 1226
Published: 1983

Abstract

The synthesis is described of octahydro-1H-2-pyrindine-5,7-dione (4) and its 6-diazo and 6-bromo derivatives. These are analogues of GABA in which the carboxyl group is replaced by an enolic β-diketone. The compounds showed negligible or very weak activity as GABA agonists with respect to inhibition of [3H] GABA binding, uptake and transamination in rat brain membranes.

https://doi.org/10.1071/CH9831221

© CSIRO 1983

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