Pyrimidine N-oxides. IV. The N,N'-dihydroxy derivatives of phenobarbital and veronal

Abstract

5-Ethyl-1,3-dihydroxy-5-phenylbarbituric acid (N,N'-dihydroxyphenobarbital) and 5,5-diethyl-1,3-dihydroxybarbituric acid (N,N'-dihydroxyveronal) have been prepared by the condensation of 1,3-dibenzyloxyurea with ethylphenylmalonyl dichloride and diethylmalonyl dichloride respectively, followed by the removal of the benzyl protecting groups from the intermediate dibenzyloxy derivatives.