Peptide synthesis with 1-Aminocyclopropane-1-carboxylic acid

Abstract

Peptide derivatives of 1-aminocyclopropane-1-carboxylic acid have been synthesized by model active ester coupling reactions in order to compare the steric effect of this plant amino acid with that of its open-chain congener 2-methylalanine. An analogue of leucine-enkephalin containing the alicyclic amino acid has also been prepared.