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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Thermal cyclization experiments with benzoyl-DL-kynurenylglycine and related compounds

DE Rivett and HC Stewart

Australian Journal of Chemistry 33(3) 625 - 631
Published: 1980

Abstract

Thermal cyclization of benzoyl-DL-kynurenylglycine to give a tricyclic 1,4-benzodiazepine derivative is discussed. Proposed formation of an initial pyrrolinone intermediate in this reaction has been supported by cyclization experiments with the analogous acyl dipeptide benzoyl-DL-2- phenacylglycylglycine,which lacks the aromatic amino group of kynurenine. The behaviour of some other related compounds is also considered.

https://doi.org/10.1071/CH9800625

© CSIRO 1980

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