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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Prediction of the Absolute Configurations of the Enantiomers of Racemic Primary and Secondary Alcohols and Primary Amines by Kinetic Resolution with (2R,3R)-2,3-Diacetoxysuccinic Anhydride

KH Bell

Australian Journal of Chemistry 32(12) 2625 - 2629
Published: 1979

Abstract

The absolute configurations of the enantiomers of a variety of racemic secondary and primary alcohols and racemic primary amines have been correctly predicted from the results of kinetic resolution with (2R,3R)-2,3-diacetoxysuccinic anhydride. In the prediction model (1), allocation of relative sizes to the groups attached to the chiral centre was based on conformational free energy differences.

https://doi.org/10.1071/CH9792625

© CSIRO 1979

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