Reaction of peri-Aminonaphthoquinones and Dihydroperimidinones with piperidine

Abstract

Reaction of methyl-substituted 5-amino-1,4-naphthoquinones with piperidine gave preferentially 3-piperidino derivatives. The corresponding orientation also resulted from amination of the dihydroperimidinone system (1), a slower process. When position 3 of the naphthoquinone was substituted by a methyl group, preferential side-chain amination of that group was observed.