New synthesis of 1,2-benzisoxazole derivatives

Abstract

N-Phenylsalicylohydroxamic acids, salicylohydroxamic acids, o- hydroxyacetophenone oximes and salicylaldoximes gave the corresponding N-phenyl-1,2-benzisoxazol-3(2H)-ones, 1,2-benzisoxazol-3-ols, 3-methyl- 1,2-benzisoxazoles and 1,2-benzisoxazoles when treated with thionyl chloride in the presence of dry pyridine in anhydrous ether at 0°C.